公开(公告)号：US11819570B2

公开(公告)日：2023-11-21

申请号：US17055032

申请日：2019-05-31

申请人： National University Corporation Tokai National Higher Education and Research System ,  National University Corporation Tokyo Medical and Dental University

发明人： Takayoshi Suganami ,  Miyako Tanaka ,  Akira Matsumoto ,  Hiroko Matsumoto ,  Yuki Morooka ,  Yuji Miyahara

IPC分类号： A61K9/06 ,  A61K38/28 ,  A61K47/32 ,  A61M37/00

CPC分类号： A61K9/06 ,  A61K38/28 ,  A61K47/32 ,  A61M37/0015 ,  A61M2037/0023

摘要： A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.

公开(公告)号：US20200166506A1

公开(公告)日：2020-05-28

申请号：US16608609

申请日：2018-04-25

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Yuji Miyahara ,  Akira Matsumoto ,  Tatsuro Goda ,  Yukichi Horiguchi

IPC分类号： G01N33/543 ,  G01N27/12 ,  G01N1/38 ,  G01N33/569 ,  G01N33/553

摘要： A modified nanoparticle includes a nanoparticle, a dispersibility improving group bound to a surface of the nanoparticle, and an oligosaccharide that is bound to the surface of the nanoparticle, and that selectively captures a specific virus or bacterium. A reagent for detection of a specific virus or bacterium by resistive pulse sensing is also provided, the reagent including the modified nanoparticle.

公开(公告)号：US11141486B2

公开(公告)日：2021-10-12

申请号：US15770125

申请日：2016-10-24

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Akira Matsumoto ,  Hiroko Matsumoto ,  Takayoshi Suganami ,  Miyako Tanaka ,  Yuji Miyahara

IPC分类号： A61K47/32 ,  A61K38/28 ,  A61M5/32 ,  A61M5/142 ,  A61K9/00 ,  A61K9/70 ,  A61M25/00 ,  A61M37/00 ,  C08F220/56 ,  A61K47/16

摘要： An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

公开(公告)号：US09114177B2

公开(公告)日：2015-08-25

申请号：US14358816

申请日：2012-11-19

申请人： THE UNIVERSITY OF TOKYO ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  NanoCarrier Co., Ltd.

发明人： Kazunori Kataoka ,  Takehiko Ishii ,  Mitsuru Naito ,  Akira Matsumoto ,  Yasuki Kato

IPC分类号： A61K31/713 ,  A61K47/48 ,  C08G81/00 ,  C08G69/40 ,  C08G69/42

CPC分类号： A61K47/48323 ,  A61K31/713 ,  A61K47/48215 ,  A61K47/60 ,  A61K47/6455 ,  C08G69/40 ,  C08G69/42 ,  C08G81/00 ,  C08G2650/28

摘要： A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.

摘要翻译： 嵌段共聚物包括聚氨基酸链段和亲水性聚合物链段。 聚氨基酸链段包括至少一个具有含有阳离子基团的侧链的氨基酸残基和至少一个具有含有取代的苯基硼酸基团的侧链的氨基酸残基。 在取代的苯基硼酸基团中，苯基环的至少一个氢被取代，使得苯基硼酸基团的pKa小于8.这种嵌段共聚物用作同时赋予基于生物技术的药物稳定性的载体 并在受影响的区域提供药物的合适的药物释放性质。

公开(公告)号：US20150051347A1

公开(公告)日：2015-02-19

申请号：US14358816

申请日：2012-11-19

申请人： THE UNIVERSITY OF TOKYO ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  NanoCarrier Co., Ltd.

发明人： Kazunori Kataoka ,  Takehiko Ishii ,  Mitsuru Naito ,  Akira Matsumoto ,  Yasuki Kato

IPC分类号： A61K47/48 ,  A61K31/713 ,  C08G81/00

CPC分类号： A61K47/48323 ,  A61K31/713 ,  A61K47/48215 ,  A61K47/60 ,  A61K47/6455 ,  C08G69/40 ,  C08G69/42 ,  C08G81/00 ,  C08G2650/28

摘要： A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.

摘要翻译： 嵌段共聚物包括聚氨基酸链段和亲水性聚合物链段。 聚氨基酸链段包括至少一个具有含有阳离子基团的侧链的氨基酸残基和至少一个具有含有取代的苯基硼酸基团的侧链的氨基酸残基。 在取代的苯基硼酸基团中，苯基环的至少一个氢被取代，使得苯基硼酸基团的pKa小于8.这种嵌段共聚物用作同时赋予基于生物技术的药物稳定性的载体 并在受影响的区域提供药物的合适的药物释放性质。