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公开(公告)号：US20220370491A1
公开(公告)日：2022-11-24
申请号：US17760908
申请日：2020-09-16
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori Yokota , Testuya Nagata , Hideki Furukawa , Takatoshi Yogo , Yasuo Nakagawa , Shigekazu Sasaki , Ryosuke Tokunoh , Tomohiro Seki , Kosuke Hidaka , Fumiaki Kikuchi , Osamu Kubo , Takahito Kasahara , Takuto Kojima , Junsi Wang , Norihito Tokunaga
IPC分类号： A61K31/713 , A61K47/54 , A61P25/00 , A61K9/00
摘要： The object of the present invention is to provide a nucleic acid agent that is efficiently delivered to the nervous system, for example, the central nervous system to which drug delivery can be prevented by BBB, and produces an antisense effect on the target transcriptional product at the delivery site, and a composition comprising the same. In an embodiment, the present invention provides a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand that hybridizes to a part of a target transcriptional product and has an antisense effect on the target transcriptional product, and a second nucleic acid strand that comprises a base sequence complementary to the first nucleic acid strand and is bound to a C22-35 alkyl group optionally substituted with a hydroxy group or an analog thereof.
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公开(公告)号：US20230037538A1
公开(公告)日：2023-02-09
申请号：US17847456
申请日：2022-06-23
发明人： Dennis Solas , Anatoliy Kitaygorodskyy , Kumar Paulvannan , Vishwanath R. Lingappa , Masato Yoshikawa , Masahiro Ito , Yuta Tanaka , Keiko Kakegawa , Tomohiro Ohashi , Takuto Kojima , Akinori Toita , Osamu Kubo , Fumiaki Kikuchi , Florian Pünner , Junsi Wang
IPC分类号： C07D217/20 , C07D405/06 , C07D471/04 , C07D401/10 , C07D405/10 , C07D413/10 , C07D405/12 , C07D401/12 , A61P25/28
摘要： The present invention relates to compounds expected to be useful in the prevention and/or treatment of diseases such as amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, frontotemporal lobar degeneration, multisystem proteinopathy and the like, a method for preventing or treating such diseases, and the like.
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公开(公告)号：US10435399B2
公开(公告)日：2019-10-08
申请号：US16049359
申请日：2018-07-30
发明人： Masahiro Ito , Hideyuki Sugiyama , Osamu Kubo , Fumiaki Kikuchi , Takeshi Yasui , Keiko Kakegawa , Zenichi Ikeda , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Akinori Toita , Takuto Kojima , Yasutomi Asano , Ayumu Sato , Hironobu Maezaki , Shinobu Sasaki , Hironori Kokubo , Misaki Homma , Minoru Sasaki , Yasuhiro Imaeda
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D487/04 , A61P25/28 , C07D471/04
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US12084436B2
公开(公告)日：2024-09-10
申请号：US17426971
申请日：2020-01-29
发明人： Masahiro Ito , Takeshi Yamamoto , Keiko Kakegawa , Hideyuki Sugiyama , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Osamu Kubo , Akinori Toita , Takuto Kojima , Fumiaki Kikuchi , Minoru Sasaki , Misaki Homma , Yasuhiro Imaeda , Hironobu Maezaki , Shiinobu Sasaki , Ayumu Sato , Hirotaka Kamitani , Yasutomi Asano , Hironori Kokubo , Masato Yoshikawa
IPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.
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