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9 条记录 (耗时 0.033 秒)

    Chromene-3-carboxylate derivatives
    1.
    发明授权
    Chromene-3-carboxylate derivatives 失效
    色烯-3-羧酸酯衍生物

    公开(公告)号：US06218427B1

    公开(公告)日：2001-04-17

    申请号：US09242898

    申请日：1999-04-26

    申请人： Natsuki Ishizuka ,  Ken-ichi Matsumura ,  Katsunori Sakai ,  Toshiro Konoike ,  Tadahiko Yorifuji ,  Seijiro Hara ,  Yoshiyuki Matsuo

    发明人： Natsuki Ishizuka ,  Ken-ichi Matsumura ,  Katsunori Sakai ,  Toshiro Konoike ,  Tadahiko Yorifuji ,  Seijiro Hara ,  Yoshiyuki Matsuo

    IPC分类号： A61K3135

    CPC分类号： C07D407/04 ,  C07D311/60 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14

    摘要： The present invention provides a compound of the formula (I): wherein R1, R2, R3 and R4 are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like, R5 is optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R6 is hydrogen, optionally substituted alkyl or the like, R7 is hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclic or the like, A is S or O and a broken line represents presence or absence of a bond, pharmaceutically acceptable salt or hydrate thereof and a pharmaceutical composition or a pharmaceutical composition for use as an endothelin receptor antagonist, a peripheral circulation insufficiency-improving agent or a macrophage foam cell formation inhibitor comprising the compound.

    摘要翻译： 本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地为氢，任选取代的烷基，羟基，任选取代的烷氧基等，R 5为任选取代的烷基，任选取代的芳基， 取代的杂环等，R 6是氢，任选取代的烷基等，R 7是氢，任选取代的烷基，任选取代的烷氧基，任选取代的芳基，任选取代的杂环等，A是S或O，虚线代表 存在或不存在键，其药学上可接受的盐或水合物，以及用作内皮素受体拮抗剂的药物组合物或药物组合物，外周循环功能不足改善剂或包含该化合物的巨噬细胞泡沫细胞形成抑制剂。

    Connector for towing vehicle and method of manufacturing same
    2.
    发明授权
    Connector for towing vehicle and method of manufacturing same 有权
    牵引车连接器及其制造方法

    公开(公告)号：US06814581B2

    公开(公告)日：2004-11-09

    申请号：US10611242

    申请日：2003-06-30

    申请人： Yoshiyuki Matsuo ,  Masashi Ooi ,  Yukihisa Nakagawa ,  Kazuhiro Aoki

    发明人： Yoshiyuki Matsuo ,  Masashi Ooi ,  Yukihisa Nakagawa ,  Kazuhiro Aoki

    IPC分类号： H01R1352

    CPC分类号： H01R13/5202 ,  H01R11/12 ,  H01R13/5213 ,  H01R13/5216

    摘要： A connection body (41), of a connector for a towing vehicle, to be connected to a wire harness of a to-be-towed object and a connection body (42) of the connector to be connected to a wire harness of a towing vehicle body are approximately cylindrical. Terminals (32, 33) inside the connection bodies (41, 42) are composed of a common metal piece (31). The connector is connected to a wire harness (35) of the towing vehicle body not by using an exclusive cylindrical connector but by directly connecting a core wire to the terminal (32). To prevent water from penetrating into the connector, an O-ring (38), a sealing medium (57), and a rubber plug (59) are mounted on the connector. A protector (37) is installed on an insertion portion of the wire harness (35) of the towing vehicle body into the housing (30).

    Connector
    5.
    发明授权
    Connector 有权
    连接器

    公开(公告)号：US07037133B2

    公开(公告)日：2006-05-02

    申请号：US11046982

    申请日：2005-01-31

    申请人： Yoshiyuki Matsuo

    发明人： Yoshiyuki Matsuo

    IPC分类号： H01R13/648

    CPC分类号： H01R13/73 ,  H01R13/56

    摘要： A connector has a flat wide housing (20) formed of synthetic resin and a plurality of female terminal fittings (41) are accommodated inside the housing (20). Each terminal fittings (41) includes a barrel (44) fixed to an end of an electric wire (70) and a box-shaped body (43) forward from the barrel (44) and configured for connection with a terminal fitting of a mating connector. A wall of the housing (20) surrounding the terminal fittings (41) is constructed of a thin part (22) forward from a midway position in a longitudinal direction of the housing (20) and of a thick part (23) thicker than the thin part (22) and rearward from the midway position. The body (43) of each of the female terminal fittings (41) is disposed partly in the thin part (22) and partly in the thick part (23).

    摘要翻译： 连接器具有由合成树脂形成的扁平宽的壳体（20），并且多个阴端子接头（41）容纳在壳体（20）内。 每个端子接头（41）包括固定到电线（70）的端部的筒体（44）和从筒体（44）向前的箱形主体（43），并且构造成用于与配合的端子接头 连接器。 围绕端子配件（41）的壳体（20）的壁由位于壳体（20）的纵向方向上的中间位置的前方的薄壁部分（22）和厚度大于所述壳体 薄部分（22）并且从中间位置向后。 每个阴端子配件（41）的主体（43）部分地设置在薄部（22）中，部分地设置在厚部（23）中。

    Connector
    6.
    发明申请
    Connector 有权
    连接器

    公开(公告)号：US20050181679A1

    公开(公告)日：2005-08-18

    申请号：US11046982

    申请日：2005-01-31

    申请人： Yoshiyuki Matsuo

    发明人： Yoshiyuki Matsuo

    IPC分类号： H01R13/40 ,  H01R13/56 ,  H01R13/73

    CPC分类号： H01R13/73 ,  H01R13/56

    摘要： A connector has a flat wide housing (20) formed of synthetic resin and a plurality of female terminal fittings (41) are accommodated inside the housing (20). Each terminal fittings (41) includes a barrel (44) fixed to an end of an electric wire (70) and a box-shaped body (43) forward from the barrel (44) and configured for connection with a terminal fitting of a mating connector. A wall of the housing (20) surrounding the terminal fittings (41) is constructed of a thin part (22) forward from a midway position in a longitudinal direction of the housing (20) and of a thick part (23) thicker than the thin part (22) and rearward from the midway position. The body (43) of each of the female terminal fittings (41) is disposed partly in the thin part (22) and partly in the thick part (23).

    摘要翻译： 连接器具有由合成树脂形成的扁平宽的壳体（20），并且多个阴端子接头（41）容纳在壳体（20）内。 每个端子接头（41）包括固定到电线（70）的端部的筒体（44）和从筒体（44）向前的箱形主体（43），并且构造成用于与配合的端子接头 连接器。 围绕端子配件（41）的壳体（20）的壁由位于壳体（20）的纵向方向上的中间位置的前方的薄壁部分（22）和厚度大于所述壳体 薄部分（22）并且从中间位置向后。 每个阴端子配件（41）的主体（43）部分地设置在薄部（22）中，部分地设置在厚部（23）中。

    Head module, liquid ejection head, liquid ejection apparatus, and method of fabricating head module
    7.
    发明申请
    Head module, liquid ejection head, liquid ejection apparatus, and method of fabricating head module 审中-公开
    头模块，液体喷射头，液体喷射装置和制造头模块的方法

    公开(公告)号：US20070008375A1

    公开(公告)日：2007-01-11

    申请号：US11473585

    申请日：2006-06-23

    申请人： Toru Tanikawa ,  Makoto Ando ,  Yoshiyuki Matsuo

    发明人： Toru Tanikawa ,  Makoto Ando ,  Yoshiyuki Matsuo

    IPC分类号： B41J2/14 ,  B41J2/16

    CPC分类号： B41J2/14072 ,  B41J2/1603 ,  B41J2/1623 ,  B41J2/1625 ,  B41J2/1631 ,  B41J2/1634 ,  B41J2202/20

    摘要： A head module includes a nozzle sheet, a wiring board, and a module frame having a plurality of head-chip positioning holes formed therein, and a head chip including an electrode. The head chip is disposed in each head-chip positioning hole. The nozzle sheet is disposed on a first surface of the module frame so as to partially cover the head-chip positioning hole. The size of the nozzle sheet is set to a minimum size required for partially covering the head-chip positioning hole. The head chip is disposed from a second surface of the module frame. The electrode is exposed through an area of the head-chip positioning hole not covered by the nozzle sheet. An electrode of the wiring board is electrically connected to the electrode of the head chip and the wiring board is disposed on the first surface of the module frame so as to cover the exposed electrode.

    摘要翻译： 头模块包括喷嘴片，布线板和形成有多个头芯片定位孔的模块框架，以及包括电极的头芯片。 头芯片设置在每个头片定位孔中。 喷嘴片设置在模块框架的第一表面上，以便部分地覆盖头芯片定位孔。 将喷嘴片的尺寸设定为部分覆盖头片定位孔所需的最小尺寸。 头芯片从模块框架的第二表面设置。 电极通过未被喷嘴片覆盖的头芯片定位孔的区域露出。 布线板的电极电连接到头芯片的电极，并且布线板设置在模块框架的第一表面上以覆盖露出的电极。

    Brain edema inhibitor
    8.
    发明授权
    Brain edema inhibitor 失效
    脑水肿抑制剂

    公开(公告)号：US5945448A

    公开(公告)日：1999-08-31

    申请号：US930827

    申请日：1997-10-10

    申请人： Mitsuyoshi Ninomiya ,  Yoshiyuki Matsuo

    发明人： Mitsuyoshi Ninomiya ,  Yoshiyuki Matsuo

    IPC分类号： A61K31/00 ,  A61K31/216 ,  A61K31/222 ,  A61K31/225 ,  A61K31/506 ,  A61K38/08 ,  A61K38/12 ,  A01N37/00 ,  A61K31/21 ,  C07C69/76 ,  C07C229/00

    CPC分类号： A61K38/12 ,  A61K31/00 ,  A61K31/216 ,  A61K31/222 ,  A61K31/225 ,  A61K31/506 ,  A61K38/08 ,  Y10S514/87

    摘要： The present invention relates to a composition for treating or preventing brain edemas which comprises containing an endothelin antagonist as an active ingredient, for example, the compound of the following formula (I): ##STR1## or pharmaceutically acceptable salts or hydrates thereof, bosentan, cyclo�D-aspartyl-L-�3-(4-phenylpiperazin-1-ylcarbonyl)!-alanyl-L-aspartyl-D-�2-(2-thienyl)!glycyl-L-leucyl-D-tryptophyl!disodium or cyclo �D-Asp-L-Pro-D-Val-L-Leu-D-Trp!.Furthermore, the present invention provides a method for treating or preventing brain edemas, which comprises administering an effective amount of an endothelin antagonist and use of an endothelin antagonist for the manufacture of a medicament for treating or preventing brain edemas.An endothelin antagonist exhibits an inhibitory effect, on all brain edemas regardless of the onset mechanism and thus is highly useful in the treatment or prevention of brain edemas.

    摘要翻译： PCT No.PCT / JP96 / 01438 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年5月29日PCT公布。 WO96 / 38173 PCT出版物 日期：1996年12月5日本发明涉及用于治疗或预防脑水肿的组合物，其包含含有内皮素拮抗剂作为活性成分，例如下式（I）的化合物或其药学上可接受的盐或水合物， 波生坦，环[D-天冬氨酰基-L- [3-（4-苯基哌嗪-1-基羰基）] - 丙氨酰-L-天冬氨酰基-D- [2-（2-噻吩基）]甘氨酰基-L-亮氨酰-D-色氨酸 ]二钠或环[D-Asp-L-Pro-D-Val-L-Leu-D-Trp]。 此外，本发明提供了治疗或预防脑水肿的方法，其包括施用有效量的内皮素拮抗剂和使用内皮素拮抗剂来制备用于治疗或预防脑水肿的药物。 内皮素拮抗剂对所有脑水肿都具有抑制作用，无论发病机制如何，因此在治疗或预防脑水肿方面非常有用。

    Plug cap for insertion into a bore
    9.
    发明授权
    Plug cap for insertion into a bore 失效
    插头插入孔中

    公开(公告)号：US5662095A

    公开(公告)日：1997-09-02

    申请号：US516390

    申请日：1995-08-17

    申请人： Yoshiyuki Matsuo

    发明人： Yoshiyuki Matsuo

    IPC分类号： F02F11/00 ,  H01T13/04 ,  H01T13/06

    CPC分类号： H01T13/06

    摘要： A plug cap freely mountable on or removable from an elongated bore, especially for a spark plug in internal combustion engines or the like. The plug cap is provided with a rain cover, seal, and a pipe-holding portion. The latter has, on its internal face, a circular groove and a plurality of protrusions projecting radially inwardly. These grooves and protrusions, and the deflection thereof on insertion into the bore, give elasticity to the seal and to the pipe-holding portion. When the plug cap is pressed into the bore, there is no curling up of the pipe-holding portion, thereby ensuring a reliable seal. After insertion, the protrusions of the pipe-holding portion, which are formed integrally with the seal, are pressed against the external face of the ignition pipe, so that the latter can be held more reliably.

    摘要翻译： 一个可自由安装在细长孔上或从其可移除的塞帽，特别是用于内燃机等中的火花塞。 插头盖设有雨罩，密封件和管道保持部分。 后者在其内表面上具有圆形槽和径向向内突出的多个突起。 这些槽和突起以及在插入孔中时的偏转对密封件和管道保持部分产生弹性。 当塞帽被压入孔中时，管夹部分没有卷曲，从而确保了可靠的密封。 插入后，与密封件一体形成的管保持部的突起被压靠在点火管的外表面上，从而可以更可靠地保持。