公开(公告)号：US20050171082A1

公开(公告)日：2005-08-04

申请号：US11095988

申请日：2005-03-31

申请人： Neil Boaz ,  Sheryl Debenham

发明人： Neil Boaz ,  Sheryl Debenham

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C231/18 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C253/30 ,  C07C255/60 ,  C07C269/06 ,  C07C271/22 ,  C07D203/04 ,  C07D205/08 ,  C07D207/26 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/553 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/576 ,  C07F9/59 ,  A61K31/55 ,  A61K31/454 ,  A61K31/4025 ,  A61K31/397 ,  C07D43/02

CPC分类号： C07D203/04 ,  C07B2200/07 ,  C07C231/18 ,  C07C253/30 ,  C07C269/06 ,  C07C2601/02 ,  C07D205/08 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/59 ,  Y02P20/52 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C255/60 ,  C07C271/22

摘要： The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.

公开(公告)号：US20070244319A1

公开(公告)日：2007-10-18

申请号：US11406095

申请日：2006-04-18

申请人： Neil Boaz ,  James Ponasik

发明人： Neil Boaz ,  James Ponasik

IPC分类号： C07F17/00

CPC分类号： C07F17/02

摘要： Bidentate phosphine-nitrogen ligands are disclosed which include a phosphine linked with a nitrogen heterocycle through a chiral ferrocene backbone. The ligands can include an imidazole or a dihydroimidazole linked to the ferrocene through the 2-position. Ligands can be prepared with or without additional chirality in the heterocycle. The ligands are useful for asymmetric catalysis, such as for palladium-catalyzed asymmetric allylation and ruthenium-catalyzed asymmetric transfer hydrogenation, affording products with high enantioselectivities.

摘要翻译： 公开了二齿膦 - 氮配体，其包括通过手性二茂铁主链与氮杂环连接的膦。 配体可以包括通过2-位与二茂铁连接的咪唑或二氢咪唑。 可以在杂环中添加或不添加手性来配制配体。 该配体可用于不对称催化，例如用于钯催化的不对称烯丙基化和钌催化的不对称转移氢化，得到具有高对映选择性的产物。

公开(公告)号：US20060135804A1

公开(公告)日：2006-06-22

申请号：US11018287

申请日：2004-12-21

申请人： Neil Boaz

发明人： Neil Boaz

IPC分类号： C07F17/00

CPC分类号： C07F17/02

摘要： This invention relates to novel, substantially enantiomerically pure tetradentate ligands comprised of two phosphines and two secondary amines. These species have been used as ligands for metal catalysts for asymmetric reactions and have demonstrated good enantioselectivity, in particular as ruthenium complexes for asymmetric hydrogenation. Also disclosed are methods for making the ligands, corresponding catalyst complexes, and processes employing the ligands and catalysts. The ligands may be described by the general formula 1: R2P-L1-NH-L2-NH-L3-PR12   1

摘要翻译： 本发明涉及由两个膦和两个仲胺组成的新的基本上对映体纯的四齿配体。 这些物质已被用作用于不对称反应的金属催化剂的配体，并且已经表现出良好的对映体选择性，特别是作为用于不对称氢化的钌络合物。 还公开了制备配体，相应的催化剂配合物和使用配体和催化剂的方法。 配体可以由通式1描述：<？in-line-formula description =“In-line Formulas”end =“lead”？> R＆gt; 2＆lt; 1＆gt; > -NH-L 2 -NH-L 3 -PR 1/2> 1 公式描述=“内联公式”end =“tail”？>