公开(公告)号：US20050171082A1

公开(公告)日：2005-08-04

申请号：US11095988

申请日：2005-03-31

申请人： Neil Boaz ,  Sheryl Debenham

发明人： Neil Boaz ,  Sheryl Debenham

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C231/18 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C253/30 ,  C07C255/60 ,  C07C269/06 ,  C07C271/22 ,  C07D203/04 ,  C07D205/08 ,  C07D207/26 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/553 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/576 ,  C07F9/59 ,  A61K31/55 ,  A61K31/454 ,  A61K31/4025 ,  A61K31/397 ,  C07D43/02

CPC分类号： C07D203/04 ,  C07B2200/07 ,  C07C231/18 ,  C07C253/30 ,  C07C269/06 ,  C07C2601/02 ,  C07D205/08 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/59 ,  Y02P20/52 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C255/60 ,  C07C271/22

摘要： The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.

公开(公告)号：US20070161689A1

公开(公告)日：2007-07-12

申请号：US11714341

申请日：2007-03-06

申请人： John Acton ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

发明人： John Acton ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/416 ,  A61K31/405 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：US20050277685A1

公开(公告)日：2005-12-15

申请号：US10524697

申请日：2003-08-27

申请人： John Acton III ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

发明人： John Acton III ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

IPC分类号： C07D209/12 ,  A61K31/404 ,  A61K31/405 ,  A61K31/42 ,  A61P3/10 ,  C07D209/10 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/02 ,  C07D413/04 ,  C07D43/02

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.