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公开(公告)号:US11059808B2
公开(公告)日:2021-07-13
申请号:US15755009
申请日:2016-08-23
申请人: New York Blood Center, Inc. , The United States of America, As Represented By The Secretary, Department of Health and Human Services
IPC分类号: C07D403/12 , A61P31/18 , C07D207/34 , C07D241/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号:US10137107B2
公开(公告)日:2018-11-27
申请号:US15512493
申请日:2015-09-18
申请人: New York Blood Center, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
IPC分类号: C07D403/12 , A61K31/40 , C07D405/14 , C07D417/12 , C07D417/14 , C07D207/34 , C07C25/00 , C07C233/01 , C07D207/30 , C07D277/20 , A61P31/18
摘要: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号:US10413527B2
公开(公告)日:2019-09-17
申请号:US16178277
申请日:2018-11-01
申请人: New York Blood Center, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
IPC分类号: C07D207/30 , A61K31/40 , C07D403/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D207/34 , C07C25/00 , C07C233/01 , C07D277/20 , A61P31/18
摘要: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号:US10576059B2
公开(公告)日:2020-03-03
申请号:US16521327
申请日:2019-07-24
申请人: New York Blood Center, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
IPC分类号: C07D207/30 , A61K31/40 , C07D207/34 , C07D417/14 , C07D417/12 , C07D405/14 , C07D403/12 , A61P31/18 , C07D277/20 , C07C233/01 , C07C25/00
摘要: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
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公开(公告)号:US10035844B2
公开(公告)日:2018-07-31
申请号:US15612846
申请日:2017-06-02
发明人: Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号: C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06
CPC分类号: C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/56988
摘要: Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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6.
公开(公告)号:US12043660B2
公开(公告)日:2024-07-23
申请号:US17551066
申请日:2021-12-14
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York
发明人: Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
CPC分类号: C07K16/1063 , A61P31/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/162
摘要: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号:US09695230B2
公开(公告)日:2017-07-04
申请号:US14363740
申请日:2012-12-10
发明人: Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号: C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06
CPC分类号: C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/56988
摘要: Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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8.
公开(公告)号:US10815295B2
公开(公告)日:2020-10-27
申请号:US16044083
申请日:2018-07-24
发明人: Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号: C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06 , A61K39/00
摘要: Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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公开(公告)号:US11236152B2
公开(公告)日:2022-02-01
申请号:US15772443
申请日:2016-11-03
申请人: The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York
发明人: Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
摘要: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号:US11760790B2
公开(公告)日:2023-09-19
申请号:US16971826
申请日:2019-02-21
发明人: Paolo Lusso , Qingbo Liu , Peter Kwong , John Mascola , Young Do Kwon
IPC分类号: C07K16/10 , A61P31/18 , G01N33/569 , A61K39/00
CPC分类号: C07K16/1063 , A61P31/18 , G01N33/56988 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/76 , C07K2317/94 , G01N2333/162
摘要: Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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