公开(公告)号：US06753329B2

公开(公告)日：2004-06-22

申请号：US10321284

申请日：2002-12-17

申请人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Frank Becker

发明人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Frank Becker

IPC分类号： A61K315375

CPC分类号： C07F9/6561 ,  C07D231/54 ,  C07D403/12 ,  C07D487/04 ,  C07F9/65583

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US20100004207A1

公开(公告)日：2010-01-07

申请号：US12456539

申请日：2009-06-18

申请人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

发明人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

IPC分类号： A61K31/5377 ,  C07D413/14 ,  C07D487/04 ,  C07D413/10 ,  A61K31/519 ,  A61K31/675 ,  A61P31/18 ,  A61P35/00

CPC分类号： C07F9/65583 ,  C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US07893057B2

公开(公告)日：2011-02-22

申请号：US12456539

申请日：2009-06-18

申请人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

发明人： Nicholas Bockovich ,  Arthur Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07F9/65583 ,  C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US07605175B2

公开(公告)日：2009-10-20

申请号：US10820453

申请日：2004-04-07

申请人： Frank Becker ,  Nicholas Bockovich ,  Jon H. Come ,  Arthur F. Kluge ,  Krishna K. Murthi ,  Chris Oalmann ,  Siya Ram ,  Zhongguo Wang

发明人： Frank Becker ,  Nicholas Bockovich ,  Jon H. Come ,  Arthur F. Kluge ,  Krishna K. Murthi ,  Chris Oalmann ,  Siya Ram ,  Zhongguo Wang

IPC分类号： A61K31/416 ,  C07D231/54

CPC分类号： C40B30/04 ,  C07D231/54 ,  C07D403/12 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/6561 ,  G01N2500/10

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US20050090471A1

公开(公告)日：2005-04-28

申请号：US10492116

申请日：2002-10-15

申请人： Nicholas Bockovich ,  Arthur Kluge ,  Siya Ram ,  Zhongguo Wang ,  Chris Oalmann ,  Krishna Murthi ,  Frank Becker

发明人： Nicholas Bockovich ,  Arthur Kluge ,  Siya Ram ,  Zhongguo Wang ,  Chris Oalmann ,  Krishna Murthi ,  Frank Becker

IPC分类号： A61K31/496 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/675 ,  A61P17/14 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P43/00 ,  C07D231/54 ,  C07D403/12 ,  C07D487/04 ,  C07F9/6558 ,  C07F9/6561 ,  C40B30/04 ,  G01N33/68 ,  A61K31/519 ,  C07D487/02

CPC分类号： C07F9/6561 ,  C07D231/54 ,  C07D403/12 ,  C07D487/04 ,  C07F9/65583 ,  C40B30/04 ,  G01N2500/10

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US07786112B2

公开(公告)日：2010-08-31

申请号：US10819899

申请日：2004-04-06

申请人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

发明人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07F9/65583 ,  C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

公开(公告)号：US08097619B2

公开(公告)日：2012-01-17

申请号：US10584485

申请日：2004-12-21

申请人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

发明人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, untimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，非常重要地控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。

公开(公告)号：US20090209530A1

公开(公告)日：2009-08-20

申请号：US10584485

申请日：2004-12-21

申请人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

发明人： Nicholas Bockovich ,  Arthur F. Kluge ,  Chris Oalmann ,  Krishna K. Murthi ,  Siya Ram ,  Zhongguo Wang ,  Jianxing Huang

IPC分类号： A61K31/5377 ,  C07D413/14 ,  C07D413/12 ,  C07D403/12 ,  C07F9/08 ,  C07D401/14 ,  C07D403/14 ,  A61P35/00 ,  A61P31/12 ,  A61P17/14

CPC分类号： C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

摘要翻译： 本发明涉及新的细胞周期蛋白依赖性激酶抑制剂（cdks），具体而非排他地作为cdk /细胞周期蛋白复合物的抑制剂。 如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可用于调节细胞周期进程，最终控制细胞生长和分化。 这样的化合物可用于治疗患有与过度细胞增殖相关的疾病的受试者。