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公开(公告)号:US20080176830A1
公开(公告)日:2008-07-24
申请号:US11910731
申请日:2006-04-13
申请人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
发明人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
IPC分类号: A61K31/551 , C07D285/16 , A61K31/549 , C07D311/76 , A61K31/352 , A61K31/498 , A61P35/04 , A61P37/00 , A61P29/00 , A61P9/00 , C07D281/10 , C07D239/80 , C07D215/00 , A61K31/47 , C07D243/10
CPC分类号: C07D285/16 , C07C35/52 , C07D215/227 , C07D223/16 , C07D239/80 , C07D243/14 , C07D265/36 , C07D311/18 , C07D413/04 , C07D417/04
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US08404837B2
公开(公告)日:2013-03-26
申请号:US12600745
申请日:2008-05-16
申请人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号: C07D401/14 , C07D413/14 , C07D498/04
CPC分类号: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号:US20100179144A1
公开(公告)日:2010-07-15
申请号:US12664496
申请日:2008-06-12
申请人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Steven David Knight , Kenneth Allen Newlander , Lance H. Ridgers , Stanley J. Schmidt
发明人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Steven David Knight , Kenneth Allen Newlander , Lance H. Ridgers , Stanley J. Schmidt
IPC分类号: A61K31/5377 , C07D401/14 , A61K31/517 , C07D413/14 , A61K31/496 , C07D403/14 , A61K31/501 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/517 , C07D401/04 , C07D401/14 , C07D471/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.
摘要翻译: 发明是使用喹唑啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用喹唑啉衍生物的移植物排斥和肺损伤。
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公开(公告)号:US20100311736A1
公开(公告)日:2010-12-09
申请号:US12739176
申请日:2008-10-22
申请人: Nicholas D. Adams , Michael Gerard Darcy , Neil W. Johnson , Jiri Kasparec , Steven David Knight , Kenneth Allen Newlander , Xin Peng , Lance H. Ridgers
发明人: Nicholas D. Adams , Michael Gerard Darcy , Neil W. Johnson , Jiri Kasparec , Steven David Knight , Kenneth Allen Newlander , Xin Peng , Lance H. Ridgers
IPC分类号: A61K31/536 , A61K31/44 , C07D213/72 , A61K31/444 , C07D213/22 , A61K31/4439 , C07D401/02 , A61K31/5377 , C07D413/14 , A61K31/506 , C07D401/04 , A61K31/4709 , C07D413/02 , A61K31/498 , A61P35/00 , A61P37/06 , A61P29/00 , A61P9/00 , A61P25/00
CPC分类号: C07D213/76 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.
摘要翻译: 本发明是使用吡啶磺酰胺衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用吡啶磺酰胺衍生物的移植排斥和肺损伤。
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公开(公告)号:US07208487B2
公开(公告)日:2007-04-24
申请号:US10538228
申请日:2003-12-12
申请人: Gustave Bergnes , Dashyant Dhanak , Steven David Knight , Pu Ping Lu , David J. Morgans, Jr. , Kenneth Allen Newlander
发明人: Gustave Bergnes , Dashyant Dhanak , Steven David Knight , Pu Ping Lu , David J. Morgans, Jr. , Kenneth Allen Newlander
IPC分类号: C07D403/06 , A61K31/57
CPC分类号: C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US07528137B2
公开(公告)日:2009-05-05
申请号:US11262506
申请日:2005-10-27
申请人: Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
发明人: Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
IPC分类号: C07D271/02 , C07D291/00 , C07D239/70
CPC分类号: C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US07214800B2
公开(公告)日:2007-05-08
申请号:US10435069
申请日:2003-05-08
申请人: Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
发明人: Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
IPC分类号: C07D27/12 , C07D291/00 , C07D239/70
CPC分类号: C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号:US20090215818A1
公开(公告)日:2009-08-27
申请号:US12374486
申请日:2007-07-24
IPC分类号: A61K31/4188 , C07D471/02
CPC分类号: C07D471/04 , A61K9/0019 , A61K9/2063 , A61K9/4858 , A61K47/10
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using thiozolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiozolidinedione derivatives.
摘要翻译: 发明了使用噻唑烷二酮衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用噻唑烷二酮衍生物的移植物排斥和肺损伤。
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公开(公告)号:US07482343B2
公开(公告)日:2009-01-27
申请号:US11600683
申请日:2006-11-15
申请人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
发明人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
IPC分类号: A61K31/513 , C07D239/36
CPC分类号: C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US07166595B2
公开(公告)日:2007-01-23
申请号:US10429195
申请日:2003-05-02
申请人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
发明人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
IPC分类号: C07D239/36 , A61K31/513 , A61K31/517 , C07D239/70
CPC分类号: C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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