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公开(公告)号:US07208487B2
公开(公告)日:2007-04-24
申请号:US10538228
申请日:2003-12-12
申请人: Gustave Bergnes , Dashyant Dhanak , Steven David Knight , Pu Ping Lu , David J. Morgans, Jr. , Kenneth Allen Newlander
发明人: Gustave Bergnes , Dashyant Dhanak , Steven David Knight , Pu Ping Lu , David J. Morgans, Jr. , Kenneth Allen Newlander
IPC分类号: C07D403/06 , A61K31/57
CPC分类号: C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US07041676B2
公开(公告)日:2006-05-09
申请号:US10462002
申请日:2003-06-12
申请人: Andrew McDonald , Pu-Ping Lu , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight
发明人: Andrew McDonald , Pu-Ping Lu , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight
IPC分类号: C07D217/00 , A61K31/47
CPC分类号: C07D401/06 , C07D217/24
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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3.Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives 失效
标题翻译: 用杂环稠合嘧啶酮衍生物调节KSP驱动蛋白活性公开(公告)号:US07332498B2
公开(公告)日:2008-02-19
申请号:US11284806
申请日:2005-11-23
IPC分类号: A61K31/519 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D498/04 , C07D211/78 , C07D211/82 , C07D211/70 , C07D211/90 , C07D211/72 , C07D211/84 , C07D213/84 , C07D213/72 , C07D213/78 , C07D213/46 , C07D213/56
CPC分类号: C07D471/04 , C07D475/02 , C07D487/04
摘要: A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts thereof, where the variables are as defined further herein.
摘要翻译: 一种在体外调节KSP驱动蛋白活性的方法,包括使KSP驱动蛋白与至少一种选自式I表示的化合物的化学实体及其药学上可接受的盐接触,其中变量如本文进一步定义。
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公开(公告)号:US08329928B2
公开(公告)日:2012-12-11
申请号:US13349795
申请日:2012-01-13
申请人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号: C07D311/22
CPC分类号: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US20110230550A1
公开(公告)日:2011-09-22
申请号:US13075076
申请日:2011-03-29
申请人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号: A61K31/352 , A61P35/00
CPC分类号: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US06924376B2
公开(公告)日:2005-08-02
申请号:US10412712
申请日:2003-04-11
申请人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号: C07D233/02 , A61K31/337 , A61K31/352 , A61K31/36 , A61K31/381 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/433 , A61K31/4433 , A61K45/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P31/10 , A61P35/00 , A61P37/00 , A61P43/00 , C07D311/22 , C07D311/36 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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7.3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use 有权
标题翻译: 3H-吡啶并嘧啶-4-酮化合物,组合物及其使用方法公开(公告)号:US07038048B2
公开(公告)日:2006-05-02
申请号:US10444283
申请日:2003-05-22
IPC分类号: C07D471/04 , A61K31/519
CPC分类号: C07D471/04 , C07D475/02 , C07D487/04
摘要: Provided herein are certain compounds of Formula I: that can be used to treat diseases of proliferating cells. The compounds are KSP kinesin inhibitors, particularly inhibitors of human KSP.
摘要翻译: 本文提供了某些式I化合物:其可用于治疗增殖细胞的疾病。 这些化合物是KSP驱动蛋白抑制剂,特别是人KSP的抑制剂。
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公开(公告)号:US08119678B2
公开(公告)日:2012-02-21
申请号:US13075076
申请日:2011-03-29
申请人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号: A61K31/4164
CPC分类号: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号:US07482343B2
公开(公告)日:2009-01-27
申请号:US11600683
申请日:2006-11-15
申请人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
发明人: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
IPC分类号: A61K31/513 , C07D239/36
CPC分类号: C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US07476743B2
公开(公告)日:2009-01-13
申请号:US10529634
申请日:2003-10-02
申请人: Xiangping Qian , Gustave Bergnes , David J. Morgans, Jr. , Steven David Knight , Dashyant Dhanak
发明人: Xiangping Qian , Gustave Bergnes , David J. Morgans, Jr. , Steven David Knight , Dashyant Dhanak
IPC分类号: C07D249/12 , A01N43/64
CPC分类号: C07D249/12 , C07D403/04
摘要: 1,2,4-Tiazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的1,2,4-噻唑-5-酮。
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