-
公开(公告)号:US20080176830A1
公开(公告)日:2008-07-24
申请号:US11910731
申请日:2006-04-13
申请人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
发明人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
IPC分类号: A61K31/551 , C07D285/16 , A61K31/549 , C07D311/76 , A61K31/352 , A61K31/498 , A61P35/04 , A61P37/00 , A61P29/00 , A61P9/00 , C07D281/10 , C07D239/80 , C07D215/00 , A61K31/47 , C07D243/10
CPC分类号: C07D285/16 , C07C35/52 , C07D215/227 , C07D223/16 , C07D239/80 , C07D243/14 , C07D265/36 , C07D311/18 , C07D413/04 , C07D417/04
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
-
公开(公告)号:US20100113444A1
公开(公告)日:2010-05-06
申请号:US12305675
申请日:2007-06-22
申请人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号: A61K31/506 , C07D239/60 , C07D401/04 , C07D405/04 , C07D413/06 , A61K31/505 , A61K31/5377 , A61P7/06 , A61P9/00
CPC分类号: C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要: The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I),(I)的某些嘧啶四酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
-
公开(公告)号:US08324208B2
公开(公告)日:2012-12-04
申请号:US12305675
申请日:2007-06-22
申请人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号: C07D239/54 , A61K31/515
CPC分类号: C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要: The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些嘧啶四酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
-
公开(公告)号:US20080262027A1
公开(公告)日:2008-10-23
申请号:US12092993
申请日:2006-11-03
申请人: Kevin J. Duffy , Duke M. Fitch , Antony N. Shaw
发明人: Kevin J. Duffy , Duke M. Fitch , Antony N. Shaw
IPC分类号: A61K31/437 , A61P7/06 , A61P7/00 , C07D471/04
CPC分类号: C07D471/04
摘要: This invention relates to newly identified compounds for inhibiting YAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of YAK3 proteins.
摘要翻译: 本发明涉及新鉴定的用于抑制YAK3蛋白的化合物和用于治疗与YAK3蛋白的不平衡或不适当活性相关的疾病的方法。
-
公开(公告)号:US20090203692A1
公开(公告)日:2009-08-13
申请号:US11912965
申请日:2006-05-18
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
IPC分类号: A61K31/4709 , C07D417/14 , C07D417/06 , A61K31/5377 , A61K31/498 , A61P7/06 , A61P7/00
CPC分类号: C07D417/12 , C07D417/14
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
-
公开(公告)号:US20080214455A1
公开(公告)日:2008-09-04
申请号:US11912969
申请日:2006-05-03
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
IPC分类号: C07D417/02 , C07D417/14 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K38/22 , A61P7/00
CPC分类号: C07D417/06
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
-
公开(公告)号:US07452874B2
公开(公告)日:2008-11-18
申请号:US11650838
申请日:2007-01-08
IPC分类号: C07D231/46 , A61K31/4152 , A61K31/655
CPC分类号: C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
-
公开(公告)号:US20130078213A1
公开(公告)日:2013-03-28
申请号:US13593739
申请日:2012-08-24
申请人: Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人: Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号: C07D403/12 , A61K45/06 , A61K31/4155 , C07D231/46 , A61K31/415
CPC分类号: C07D231/46 , A61K31/415 , A61K31/4155 , A61K31/655 , A61K45/06 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
-
公开(公告)号:US07674887B2
公开(公告)日:2010-03-09
申请号:US12141379
申请日:2008-06-18
IPC分类号: C07D231/46 , C07C215/76
CPC分类号: C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译: 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物(包括人)中治疗血小板减少症的方法,其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
-
公开(公告)号:US20090176973A1
公开(公告)日:2009-07-09
申请号:US12141379
申请日:2008-06-18
申请人: Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人: Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号: C09B27/00 , C07C59/42 , C07D231/38
CPC分类号: C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译: 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物(包括人)中治疗血小板减少症的方法,其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
-
-
-
-
-
-
-
-
-