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公开(公告)号：US06284197B1
公开(公告)日：2001-09-04
申请号：US09127382
申请日：1998-07-31
IPC分类号： G01N3353
CPC分类号： G01N21/75 , B82Y15/00 , B82Y30/00 , G02F1/1337 , G02F1/133719 , Y10S436/805
摘要： Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting analytes. The device comprises a substrate onto which a self-assembled monolayer is attached and a mesogenic layer which is anchored by the self-assembled monolayer. The mesogenic layer undergoes a change in conformation in response to the molecular interaction.
摘要翻译： 作为自组装单层和其他分子的组分的分子之间的相互作用可通过使用介晶层被扩增并转导成光信号。 本发明提供一种用于检测分析物的装置和方法。 该装置包括其上附接有自组装单层的基底和由自组装单层锚定的介晶层。 介晶层响应于分子相互作用而发生构象变化。
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公开(公告)号：US08246911B2
公开(公告)日：2012-08-21
申请号：US10044899
申请日：2002-01-09
IPC分类号： G01N21/75 , G01N33/53 , G01N27/00 , G02F1/1337 , G02F1/13
CPC分类号： G01N21/75 , B82Y15/00 , B82Y30/00 , G02F1/1337 , G02F1/133719 , Y10S436/805
摘要： Interactions between molecules that are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides for a method for detecting an analyte, comprising contacting with said analyte a recognition moiety for said analyte, wherein said contacting causes at least a portion of a plurality of mesogens proximate to said recognition moiety to detectably switch from a first orientation to a second orientation upon contacting said analyte with said recognition moiety; and detecting said second orientation of said at least a portion of said plurality of mesogens, whereby said analyte is detected.
摘要翻译： 作为自组装单层和其他分子的组分的分子之间的相互作用可以通过使用介晶层被扩增并转导成光信号。 本发明提供了一种用于检测分析物的方法，包括与所述分析物接触所述分析物的识别部分，其中所述接触导致接近所述识别部分的多个介晶的至少一部分可检测地从第一取向切换到 使所述分析物与所述识别部分接触时的第二取向; 并且检测所述多个介晶的所述至少一部分的所述第二取向，从而检测所述分析物。
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公开(公告)号：US06858423B1
公开(公告)日：2005-02-22
申请号：US09637844
申请日：2000-08-10
CPC分类号： G01N21/75 , B82Y15/00 , B82Y30/00 , G02F1/1337 , G02F1/133719
摘要： Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting analytes. The device comprises a substrate onto which a self-assembled monolayer is attached and a mesogenic layer which is anchored by the self-assembled monolayer. The mesogenic layer undergoes a change in conformation in response to the molecular interaction.
摘要翻译： 作为自组装单层和其他分子的组分的分子之间的相互作用可通过使用介晶层被扩增并转导成光信号。 本发明提供一种用于检测分析物的装置和方法。 该装置包括其上附接有自组装单层的基底和由自组装单层锚定的介晶层。 介晶层响应于分子相互作用而发生构象变化。
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公开(公告)号：US06852285B2
公开(公告)日：2005-02-08
申请号：US09898132
申请日：2001-07-03
IPC分类号： G01N33/543 , G01N21/75 , G01Q60/00 , G01Q90/00 , G02F1/1337 , G01N33/53 , G01N27/00
CPC分类号： G01N21/75 , B82Y15/00 , B82Y30/00 , G02F1/1337 , G02F1/133719 , Y10S436/805
摘要： Interactions between molecules which are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides a device and methods for detecting analytes. The device comprises a substrate onto which a self-assembled monolayer is attached and a mesogenic layer which is anchored by the self-assembled monolayer. The mesogenic layer undergoes a change in conformation in response to the molecular interaction.
摘要翻译： 作为自组装单层和其他分子的组分的分子之间的相互作用可通过使用介晶层被扩增并转导成光信号。 本发明提供一种用于检测分析物的装置和方法。 该装置包括其上附接有自组装单层的基底和由自组装单层锚定的介晶层。 介晶层响应于分子相互作用而发生构象变化。
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公开(公告)号：US07662751B2
公开(公告)日：2010-02-16
申请号：US10934023
申请日：2004-09-03
IPC分类号： C40B50/00
CPC分类号： B82Y30/00 , G01N33/54373 , G01N33/569 , G01N33/56911 , Y10S436/807
摘要： Detection apparatus for use in the detection of the presence of a selected pathogen in a sample are disclosed. Such apparatus include: a substrate with a detection region on a surface thereof, the detection region having microstructures including grooves formed therein that will align liquid crystal material in contact therewith, the width and depth of the grooves being in the range of 10 μm or less; a blocking layer on the surface of the detection region of the substrate that does not disrupt the alignment of liquid crystal material in contact therewith, the blocking layer blocking nonspecific adsorption of pathogens to the surface; and a binding agent on the surface of the detection region of the substrate, the binding agent specifically binding the selected pathogen.
摘要翻译： 公开了用于检测样品中选定病原体的存在的检测装置。 这种装置包括：具有在其表面上具有检测区域的基板，检测区域具有包括形成在其中的凹槽的微结构，其将与其接触的液晶材料对准，凹槽的宽度和深度在10um或更小的范围内 ; 在基板的检测区域的表面上的阻挡层不会破坏与其接触的液晶材料的取向，阻挡层阻止病原体向表面的非特异性吸附; 和底物的检测区域的表面上的结合剂，所述结合剂特异性结合所选择的病原体。
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6.发明授权公开(公告)号：US06288392B1
公开(公告)日：2001-09-11
申请号：US09233293
申请日：1999-01-19
IPC分类号： H01J3700
CPC分类号： C23C14/225 , C23C14/048 , Y10S977/852
摘要： Scanning probe microscopy is used to quantitatively characterize structural anisotropy within obliquely deposited metal films. Whereas visual inspection of AFM images (real space or reciprocal space) reveals no obvious structural anisotropy within these gold films, by quantitative analysis of the AFM profiles, subtle structural anisotropy is observed. The quantitative characterization provides a method to estimate the influence of anisotropy on the orientations of supported mesogenic layers.
摘要翻译： 扫描探针显微镜用于定量表征倾斜沉积金属膜内的结构各向异性。 而AFM图像（实际空间或相互作用空间）的目视检查显示，在这些金膜中没有明显的结构各向异性，通过AFM谱的定量分析，观察到微小的结构各向异性。 定量表征提供了一种评估各向异性对支撑介晶层取向影响的方法。
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公开(公告)号：US06797463B2
公开(公告)日：2004-09-28
申请号：US09784232
申请日：2001-02-15
IPC分类号： C12Q170
CPC分类号： B82Y30/00 , G01N33/54373 , G01N33/569 , G01N33/56911 , Y10S436/807
摘要： Detection apparatus for use in the detection of the presence of a selected pathogen in a sample are disclosed. Such apparatus include: a substrate with a detection region on a surface thereof, the detection region having microstructures including grooves formed therein that will align liquid crystal material in contact therewith, the width and depth of the grooves being in the range of 10 &mgr;m or less; a blocking layer on the surface of the detection region of the substrate that does not disrupt the alignment of liquid crystal material in contact therewith, the blocking layer blocking nonspecific adsorption of pathogens to the surface; and a binding agent on the surface of the detection region of the substrate, the binding agent specifically binding the selected pathogen.
摘要翻译： 公开了用于检测样品中选定病原体的存在的检测装置。 这种装置包括：具有在其表面上具有检测区域的基板，检测区域具有包括形成在其中的凹槽的微结构，其将与其接触的液晶材料对准，凹槽的宽度和深度在10um或更小的范围内 ; 在基板的检测区域的表面上的阻挡层不会破坏与其接触的液晶材料的取向，阻挡层阻止病原体向表面的非特异性吸附; 和底物的检测区域的表面上的结合剂，所述结合剂特异性结合所选择的病原体。
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