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公开(公告)号：US20130217865A1
公开(公告)日：2013-08-22
申请号：US13743672
申请日：2013-01-17
申请人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Denis Bosc , Francina C. Chahal
发明人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Denis Bosc , Francina C. Chahal
IPC分类号： C07K16/30 , C07K14/415 , C12N9/10
CPC分类号： C07K16/2884 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6819 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K14/415 , C07K16/30 , C07K16/3015 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/77 , C07K2319/55 , C12N9/1077 , G01N33/574 , G01N2333/471 , G01N2333/70585
摘要： The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a tumor specific antibody. In addition, the invention provides tumor-specific antibodies and immunoconjugates comprising the tumor-specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the tumor-specific antibodies of the invention.
摘要翻译： 本发明提供了肿瘤特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本发明提供包含附着于毒素或标记物的肿瘤特异性抗体的肿瘤特异性抗体和免疫缀合物及其方法和用途。 本发明还涉及使用本发明的肿瘤特异性抗体的诊断方法和试剂盒。
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公开(公告)号：US08697075B2
公开(公告)日：2014-04-15
申请号：US13297783
申请日：2011-11-16
申请人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
发明人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
IPC分类号： A61K39/00 , A61K39/395 , C07K16/30
CPC分类号： A61K39/0011 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/21 , C07K2317/41 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N33/57488 , G01N2500/10
摘要： The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the cancer specific antibodies of the invention. Further, the invention provides a novel cancer-associated antigen and its uses thereof.
摘要翻译： 本发明提供癌特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本发明提供癌症特异性抗体和包含附着于毒素或标记物的癌症特异性抗体的免疫缀合物及其方法和用途。 本发明还涉及使用本发明的癌症特异性抗体的诊断方法和试剂盒。 此外，本发明提供了一种新的癌症相关抗原及其用途。
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公开(公告)号：US20100254982A1
公开(公告)日：2010-10-07
申请号：US11722420
申请日：2005-12-21
申请人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
发明人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/74 , C12N1/21 , C07K16/18 , C07K16/28 , G01N33/574 , A61K38/16 , A61K31/7088 , A61K39/00 , C12Q1/68 , A61P35/00
CPC分类号： A61K39/0011 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/21 , C07K2317/41 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N33/57488 , G01N2500/10
摘要： The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the cancer specific antibodies of the invention. Further, the invention provides a novel cancer-associated antigen and its uses thereof.
摘要翻译： 本发明提供癌特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本发明提供癌症特异性抗体和包含附着于毒素或标记物的癌症特异性抗体的免疫缀合物及其方法和用途。 本发明还涉及使用本发明的癌症特异性抗体的诊断方法和试剂盒。 此外，本发明提供了一种新的癌症相关抗原及其用途。
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公开(公告)号：US08383117B2
公开(公告)日：2013-02-26
申请号：US11570198
申请日：2005-06-10
申请人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Denis Georges Bosc , Francina C. Chahal
发明人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Denis Georges Bosc , Francina C. Chahal
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2884 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6819 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K14/415 , C07K16/30 , C07K16/3015 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/77 , C07K2319/55 , C12N9/1077 , G01N33/574 , G01N2333/471 , G01N2333/70585
摘要： The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a tumor specific antibody. In addition, the invention provides tumor-specific antibodies and immunoconjugates comprising the tumor-specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the tumor-specific antibodies of the invention.
摘要翻译： 本发明提供了肿瘤特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本发明提供包含附着于毒素或标记物的肿瘤特异性抗体的肿瘤特异性抗体和免疫缀合物及其方法和用途。 本发明还涉及使用本发明的肿瘤特异性抗体的诊断方法和试剂盒。
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公开(公告)号：US08084576B2
公开(公告)日：2011-12-27
申请号：US11722420
申请日：2005-12-21
申请人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
发明人： Nicholas Ronald Glover , Glen Christopher MacDonald , Joycelyn Entwistle , Jeannick Cizeau , Francina C. Chahal
CPC分类号： A61K39/0011 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/21 , C07K2317/41 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N33/57488 , G01N2500/10
摘要： The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods and uses thereof. The invention also relates to diagnostic methods and kits using the cancer specific antibodies of the invention. Further, the invention provides a novel cancer-associated antigen and its uses thereof.
摘要翻译： 本发明提供癌特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本发明提供癌症特异性抗体和包含附着于毒素或标记物的癌症特异性抗体的免疫缀合物及其方法和用途。 本发明还涉及使用本发明的癌症特异性抗体的诊断方法和试剂盒。 此外，本发明提供了一种新的癌症相关抗原及其用途。
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6.发明申请Antibodies Against a Cancer-Associated Epitope of Variant NFKBIB and Uses Thereof 有权抗癌相关表位NFκBB的抗体及其用途公开(公告)号：US20100322919A1
公开(公告)日：2010-12-23
申请号：US12744523
申请日：2008-11-27
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , G01N33/574 , C12N15/63 , C12N5/10 , C07K14/435
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/77 , G01N33/5023 , G01N33/57496
摘要： The present application provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of a cancer specific antibody directed to an epitope of variant Nuclear Factor Kappa-B inhibitor beta (NFKBIB). In addition, the application provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or a label, and methods of uses thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies herein. Further, the application provides novel cancer-associated epitopes and antigens of variant NFKBIB, and uses thereof.
摘要翻译： 本申请提供了针对变体核因子κB抑制剂β（NFκBB）的表位的癌症特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本申请提供癌症特异性抗体和包含附着于毒素或标签的癌症特异性抗体的免疫缀合物及其使用方法。 本申请还涉及使用本文中的癌症特异性抗体的诊断方法和试剂盒。 此外，本申请提供新的癌症相关表位和变体NFκBBIB的抗原及其用途。
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公开(公告)号：US08389286B2
公开(公告)日：2013-03-05
申请号：US13094118
申请日：2011-04-26
IPC分类号： G01N33/574
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K45/06 , A61K2039/5158 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/30 , C12Q1/6886 , C12Q2600/136 , G01N33/5011 , G01N33/57492 , G01N33/6893
摘要： The present invention provides a novel cancer-associated antigen that can be used in the treatment and diagnosis of cancer. Further, the invention provides amino acid and nucleic acid sequence of the novel antigen, binding proteins, and immunoconjugates. The invention also relates to diagnostic and therapeutic methods and kits.
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8.发明授权Antibodies against a cancer-associated epitope of variant NFKBIB and uses thereof 有权针对变异NFκBIB的癌相关表位的抗体及其用途公开(公告)号：US08426561B2
公开(公告)日：2013-04-23
申请号：US12744523
申请日：2008-11-27
IPC分类号： C07K14/00
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/18 , C07K2317/21 , C07K2317/56 , C07K2317/77 , G01N33/5023 , G01N33/57496
摘要： The present application provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of a cancer specific antibody directed to an epitope of variant Nuclear Factor Kappa-B inhibitor beta (NFKBIB). In addition, the application provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or a label, and methods of uses thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies herein. Further, the application provides novel cancer-associated epitopes and antigens of variant NFKBIB, and uses thereof.
摘要翻译： 本申请提供了针对变体核因子κB抑制剂β（NFκBB）的表位的癌症特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本申请提供癌症特异性抗体和包含附着于毒素或标签的癌症特异性抗体的免疫缀合物及其使用方法。 本申请还涉及使用本文中的癌症特异性抗体的诊断方法和试剂盒。 此外，本申请提供新的癌症相关表位和变体NFκBBIB的抗原及其用途。
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9.发明申请Antibodies Against A Cancer-Associated Epitope of Variant HNRNPG and Uses Thereof 审中-公开抗逆转录病毒HNRNPG癌症相关表位抗体及其用途公开(公告)号：US20130039931A1
公开(公告)日：2013-02-14
申请号：US13591715
申请日：2012-08-22
IPC分类号： C07K16/00 , C07K16/18 , C07K17/00 , A61K39/395 , C07K7/00 , C12N15/12 , A61K39/00 , A61P35/00 , G01N33/574 , C12N9/96 , C12N15/63 , C12N5/10 , C12N1/19 , C12N1/15 , C12N1/21 , C07H21/04
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , A61K51/1075 , C07K16/18 , C07K16/3069 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92 , C07K2319/21 , C07K2319/55 , G01N33/57496
摘要： The present application provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the application provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods and uses thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies disclosed herein. Further, the application provides novel cancer-associated epitopes and antigens, and uses thereof.
摘要翻译： 本申请提供了癌症特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本申请提供癌症特异性抗体和包含附着于毒素或标记物的癌症特异性抗体的免疫缀合物及其方法和用途。 本申请还涉及使用本文公开的癌症特异性抗体的诊断方法和试剂盒。 此外，本申请提供了新的癌症相关表位和抗原及其用途。
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10.发明授权Antibodies against a cancer-associated epitope of variant HnRNPG and uses thereof 有权针对变体HnRNPG的癌相关表位的抗体及其用途公开(公告)号：US08273550B2
公开(公告)日：2012-09-25
申请号：US12738883
申请日：2008-10-23
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , A61K51/1075 , C07K16/18 , C07K16/3069 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92 , C07K2319/21 , C07K2319/55 , G01N33/57496
摘要： The present application provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of a cancer specific antibody directed to an epitope of variant Heterogeneous Ribonucleoprotein G (HnRNPG). In addition, the application provides cancer specific antibodies and immunoconjugates comprising the cancer specific antibody attached to a toxin or label, and methods of uses thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies disclosed herein. Further, the application provides novel cancer-associated epitopes and antigens of variant HnRNPG, and uses thereof.
摘要翻译： 本申请提供了针对变体异源核糖核蛋白G（HnRNPG）的表位的癌特异性抗体的重链和轻链互补决定区的氨基酸和核酸序列。 此外，本申请提供癌特异性抗体和包含附着于毒素或标签的癌特异性抗体的免疫缀合物及其使用方法。 本申请还涉及使用本文公开的癌症特异性抗体的诊断方法和试剂盒。 此外，该应用提供了新型癌症相关表位和变体HnRNPG的抗原及其用途。
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