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公开(公告)号：US08501171B2
公开(公告)日：2013-08-06
申请号：US12659824
申请日：2010-03-23
申请人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
发明人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
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公开(公告)号：US07713524B2
公开(公告)日：2010-05-11
申请号：US10566358
申请日：2004-07-30
申请人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
发明人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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公开(公告)号：US20060182741A1
公开(公告)日：2006-08-17
申请号：US10566358
申请日：2004-07-30
申请人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
发明人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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公开(公告)号：US20100303826A1
公开(公告)日：2010-12-02
申请号：US12659824
申请日：2010-03-23
申请人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
发明人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395 , A61K39/42 , A61P31/12 , A61P37/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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5.发明申请Correlation between the fucose content/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity 审中-公开抗恒河猴和抗hla-dr抗体的岩藻糖含量/半乳糖含量比与adcc活性的相关性公开(公告)号：US20070015239A1
公开(公告)日：2007-01-18
申请号：US10575333
申请日：2004-10-20
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/2833 , C07K16/34 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/732
摘要： The present invention relates to monoclonal antibodies with high ADCC activity, characterised in having glycannic structures with a ratio (fucose content/galactose content) of 0.6 or less on the glycosylation site thereof in the Fc region. The invention also relates to pharmaceutical compositions, containing said monoclonal antibodies with high effector activity.
摘要翻译： 本发明涉及具有高ADCC活性的单克隆抗体，其特征在于具有在Fc区的糖基化位点上具有0.6或更小比例（岩藻糖含量/半乳糖含量）的甘氨酸结构。 本发明还涉及含有具有高效应物活性的所述单克隆抗体的药物组合物。
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6.发明申请Treatment of pathologies which escape the immune response, using optimised antibodies 审中-公开使用优化的抗体治疗逃避免疫应答的病理学公开(公告)号：US20050271652A1
公开(公告)日：2005-12-08
申请号：US10527666
申请日：2003-09-15
IPC分类号： A61K39/395 , A61P7/00 , A61P31/00 , A61P33/00 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/34
CPC分类号： C07K16/2833 , C07K16/2896 , C07K16/34 , C07K2317/732
摘要： The invention relates to the use of optimised human or humanised chimeric monoclonal antibodies which are produced cell lines, said antibodies having a strong affinity for receptor CD16 of the effector cells of the immune system and being able to induce the secretion of cytokines and interleukins, in particular 1′ IFN? or 1′ IL2, for the treatment of pathologies for which the target cells only express a low antigenic density and in which the effector cells can only be recruited in small quantities.
摘要翻译： 本发明涉及使用产生细胞系的优化的人或人源化嵌合单克隆抗体，所述抗体对免疫系统的效应细胞的受体CD16具有强亲和力，并能够诱导细胞因子和白细胞介素的分泌， 特别是1' 或1'IL2，用于治疗靶细胞仅表达低抗原密度并且其中仅能够少量招募效应细胞的病理学。
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公开(公告)号：US20070218052A1
公开(公告)日：2007-09-20
申请号：US10575218
申请日：2004-10-18
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , Y02A50/41 , Y02A50/484
摘要： The invention relates to human or humanised, chimeric, monoclonal, class IgG3 antibodies produced in a cell line of rat myeloma, especially line YB2/0. Said antibodies have a strong phagocytosis activity and can be administered for the treatment of cancers and infections.
摘要翻译： 本发明涉及在大鼠骨髓瘤细胞系（特别是YB2 / 0）中产生的人或人源化的，嵌合的，单克隆的IgG3抗体。 所述抗体具有强的吞噬活性，并且可以用于治疗癌症和感染。
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公开(公告)号：US08404241B2
公开(公告)日：2013-03-26
申请号：US13203317
申请日：2010-03-05
IPC分类号： A61K39/395
CPC分类号： C07K16/34 , A61K39/39591 , C07K2317/567
摘要： The invention relates to an anti-RhD monoclonal antibody, which is a tetrameric IgG1 immunoglobulin composed of two heavy chains and two light chains, the heavy chain comprising the amino acid sequence SEQ ID No. 2, harboring a phenylalanine residue at position 68, and the light chain comprising the amino acid sequence SEQ ID No. 4.
摘要翻译： 本发明涉及一种抗RhD单克隆抗体，其是由两条重链和两条轻链组成的四聚体IgG1免疫球蛋白，该重链包含在位置68处含有苯丙氨酸残基的氨基酸序列SEQ ID No.2，以及 所述轻链包含氨基酸序列SEQ ID No.4。
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公开(公告)号：US20110311556A1
公开(公告)日：2011-12-22
申请号：US13203317
申请日：2010-03-05
CPC分类号： C07K16/34 , A61K39/39591 , C07K2317/567
摘要： The invention relates to an anti-RhD monoclonal antibody, which is a tetrameric IgG1 immunoglobulin composed of two heavy chains and two light chains, the heavy chain comprising the amino acid sequence SEQ ID No. 2, harboring a phenylalanine residue at position 68, and the light chain comprising the amino acid sequence SEQ ID No. 4.
摘要翻译： 本发明涉及一种抗RhD单克隆抗体，其是由两条重链和两条轻链组成的四聚体IgG1免疫球蛋白，该重链包含在位置68处含有苯丙氨酸残基的氨基酸序列SEQ ID No.2，以及 所述轻链包含氨基酸序列SEQ ID No.4。
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公开(公告)号：US20140378663A1
公开(公告)日：2014-12-25
申请号：US14128828
申请日：2012-06-25
申请人： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
发明人： Alexandre Fontayne , Sylvie Jorieux , Celine Monnet-Mars , Philippe Mondon , Abdelhakim Kharrat , Khalil Bouayadi
CPC分类号： C07K16/28 , C07K16/2887 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/71 , C07K2317/76
摘要： A method for producing a variant of a parent polypeptide including a Fc region, which variant exhibits reduced binding to the protein C1q and to at least one receptor Fcgγ R as compared to the parent polypeptide.
摘要翻译： 用于产生包含Fc区的亲本多肽的变体的方法，所述变体与亲本多肽相比显示出降低的与蛋白质C1q的结合和至少一种受体FcγγR的结合。
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