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17 条记录 (耗时 0.022 秒)

    Anti-rhesus D monoclonal antibody
    3.
    发明授权
    Anti-rhesus D monoclonal antibody 有权
    抗猕猴D单克隆抗体

    公开(公告)号：US08404241B2

    公开(公告)日：2013-03-26

    申请号：US13203317

    申请日：2010-03-05

    申请人： Christine Gaucher ,  Sylvie Jorieux ,  Christophe De Romeuf

    发明人： Christine Gaucher ,  Sylvie Jorieux ,  Christophe De Romeuf

    IPC分类号： A61K39/395

    CPC分类号： C07K16/34 ,  A61K39/39591 ,  C07K2317/567

    摘要： The invention relates to an anti-RhD monoclonal antibody, which is a tetrameric IgG1 immunoglobulin composed of two heavy chains and two light chains, the heavy chain comprising the amino acid sequence SEQ ID No. 2, harboring a phenylalanine residue at position 68, and the light chain comprising the amino acid sequence SEQ ID No. 4.

    摘要翻译： 本发明涉及一种抗RhD单克隆抗体，其是由两条重链和两条轻链组成的四聚体IgG1免疫球蛋白，该重链包含在位置68处含有苯丙氨酸残基的氨基酸序列SEQ ID No.2，以及 所述轻链包含氨基酸序列SEQ ID No.4。

    Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII
    10.
    发明申请
    Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII 失效
    针对抗体抑制因子VIII的细胞毒性抗体

    公开(公告)号：US20090130094A1

    公开(公告)日：2009-05-21

    申请号：US12084459

    申请日：2006-11-02

    申请人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    发明人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    IPC分类号： A61K39/395 ,  C07K16/42 ,  C12N15/13 ,  A61P7/04 ,  C12N5/00

    CPC分类号： C07K16/4208 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

    摘要： The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 1, and the variable region of each of the heavy chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 2, the constant regions of the light chains and the heavy chains being constant regions from a non-murine species. The invention also relates to the use of said antibody for activating the FcγRIII receptors of cytotoxic immune cells, and to the production of a medicament especially for the treatment of haemophilia A.

    摘要翻译： 本发明涉及靶向抑制人因子VIII的抗体的抗独特型抗体，所述抗体靶向人因子VIII的C2区，其轻链的可变区由序列的核酸 其至少70％与核酸SEQ ID NO：1的鼠序列相同，并且其每个重链的可变区由核酸序列编码，其中至少70％与小鼠相同 核酸序列SEQ ID NO：2，轻链和重链的恒定区是来自非鼠类的恒定​​区。 本发明还涉及所述抗体用于激活细胞毒性免疫细胞的FcγRIII受体的用途，以及特别是用于治疗血友病A的药物的生产。