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    EXON SKIPPING THERAPY FOR DYSFERLINOPATHIES
    1.
    发明申请
    EXON SKIPPING THERAPY FOR DYSFERLINOPATHIES 失效
    肛门脱垂治疗

    公开(公告)号：US20120208865A1

    公开(公告)日：2012-08-16

    申请号：US13501892

    申请日：2010-10-18

    申请人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

    发明人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

    IPC分类号： A61K31/7105 ,  A61P21/00 ,  C07H21/02

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2320/33

    摘要： The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.

    摘要翻译： 本发明涉及恢复突变的dysferlin的功能的方法，其包括防止编码导致所述dysferlin功能障碍的氨基酸序列的一个或多个外显子的剪接的步骤。 特别地，防止外显子32的剪接。 本发明还涉及在有需要的患者中治疗偏头痛的方法，该方法包括给所述患者施用与编码氨基酸序列的一个或多个外显子正确剪接所必需的核酸序列互补的反义寡核苷酸的步骤 导致所述功能障碍。 特别地，防止外显子32的剪接。

    Exon skipping therapy for dysferlinopathies
    2.
    发明授权
    Exon skipping therapy for dysferlinopathies 失效
    外显子跳跃治疗偏头痛

    公开(公告)号：US08586560B2

    公开(公告)日：2013-11-19

    申请号：US13501892

    申请日：2010-10-18

    申请人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

    发明人： Nicolas Levy ,  Martin Krahn ,  Marc Bartoli ,  Luis Garcia

    IPC分类号： C12N15/11 ,  C12N15/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2320/33

    摘要： The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.

    摘要翻译： 本发明涉及恢复突变的dysferlin的功能的方法，其包括防止编码导致所述dysferlin功能障碍的氨基酸序列的一个或多个外显子的剪接的步骤。 特别地，防止外显子32的剪接。 本发明还涉及在有需要的患者中治疗偏头痛的方法，该方法包括给所述患者施用与编码氨基酸序列的一个或多个外显子正确剪接所必需的核酸序列互补的反义寡核苷酸的步骤 导致所述功能障碍。 特别地，防止外显子32的剪接。

    Method for analyzing D4Z4 tandem repeat arrays of nucleic acid and kit therefore
    4.
    发明授权
    Method for analyzing D4Z4 tandem repeat arrays of nucleic acid and kit therefore 有权
    因此分析核酸和试剂盒的D4Z4串联重复阵列的方法

    公开(公告)号：US09422607B2

    公开(公告)日：2016-08-23

    申请号：US13120063

    申请日：2009-09-25

    申请人： Pierre Walrafen ,  Aaron Bensimon ,  Nicolas Levy

    发明人： Pierre Walrafen ,  Anne Vannier ,  Aaron Bensimon ,  Nicolas Levy

    IPC分类号： C12Q1/68 ,  C40B30/04

    CPC分类号： C12Q1/6883 ,  C12Q1/6834 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/172 ,  C40B30/04

    摘要： The present invention relates to a method for analyzing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.

    摘要翻译： 本发明涉及一种用于分析体外代表染色体的核酸上包含的核酸的D4Z4串联重复阵列的方法，特别是涉及代表人染色体4和10的核酸以及试剂盒。 所述方法特别适用于确定所述D4Z4重复阵列中的D4Z4重复单元的数目。 所述方法基于核酸的拉伸，特别是基于Molecular Combing，并且依赖于使用具有特定设计的探针，特别是核酸探针。 本发明还涉及一种用于提供用于诊断面积性营养肌营养不良症（FSHD）的工具的方法以及诊断试剂盒。 本发明还涉及用于鉴定含有这种串联重复阵列的区域中的生物化学事件和/或遗传的方法。

    Suspension system for vehicle and tire for vehicle
    5.
    发明授权
    Suspension system for vehicle and tire for vehicle 有权
    汽车轮胎悬挂系统

    公开(公告)号：US08955565B2

    公开(公告)日：2015-02-17

    申请号：US12922302

    申请日：2009-03-17

    申请人： Frédéric Perrin ,  Nicolas Levy

    发明人： Frédéric Perrin ,  Nicolas Levy

    IPC分类号： B60C11/03 ,  B60G99/00 ,  B60G3/00 ,  B60C11/00 ,  B60C15/06 ,  B60C19/00 ,  B60G9/00

    CPC分类号： B60G3/00 ,  B60C11/00 ,  B60C15/06 ,  B60C19/001 ,  B60G9/00 ,  B60G2200/46 ,  B60G2200/462 ,  B60G2200/4622 ,  Y10S152/904

    摘要： Road-going assembly consisting of a vehicle comprising a front axle and a rear axle, and of a set of tires which are mounted on their mounting rim in order to be fitted to the front axle and the rear axle of this vehicle, the tires of the rear axle having grooves the mean depths of which are at least equal to 3 mm and at most equal to 5 mm, the tires of the front axle having grooves the mean depths of which are greater than 5 mm, this road-going assembly having, at least in the case of the rear axle, static setups (camber, toe-in) of close to zero, that is to say a camber of each wheel-tire assembly on the said axle of between −0.8 degrees and +0.8 degrees and a toe-in at each wheel of between −0.15 degrees and +0.15 degrees, the static setups of the tires of one and the same axle being equal in terms of absolute value and symmetric with respect to a plane perpendicular to the road surface.

    摘要翻译： 由包括前轴和后轴的车辆以及安装在其安装轮辋上的一组轮胎组成的行驶组件以便安装到该车辆的前轴和后桥上，轮胎 所述后桥具有凹槽，所述凹槽的平均深度至少等于3mm并且至多等于5mm，所述前轴的轮胎具有平均深度大于5mm的凹槽，所述道路组件具有 至少在后桥的情况下，静态设置（弧度，脚趾）接近零，也就是所述车轮上的每个车轮轮胎组件的弯度在-0.8度和+0.8度之间 并且在每个车轮上的脚趾在-0.15度至+0.15度之间，同一轴的轮胎的静态设置在绝对值方面是相等的，并且相对于垂直于路面的平面是对称的。

    SUSPENSION SYSTEM FOR VEHICLE AND TIRE FOR VEHICLE
    7.
    发明申请
    SUSPENSION SYSTEM FOR VEHICLE AND TIRE FOR VEHICLE 有权
    车辆轮胎悬挂系统

    公开(公告)号：US20110114236A1

    公开(公告)日：2011-05-19

    申请号：US12922302

    申请日：2009-03-17

    申请人： Frédéric Perrin ,  Nicolas Levy

    发明人： Frédéric Perrin ,  Nicolas Levy

    IPC分类号： B60C11/00

    CPC分类号： B60G3/00 ,  B60C11/00 ,  B60C15/06 ,  B60C19/001 ,  B60G9/00 ,  B60G2200/46 ,  B60G2200/462 ,  B60G2200/4622 ,  Y10S152/904

    摘要： Road-going assembly consisting of a vehicle comprising a front axle and a rear axle, and of a set of tires which are mounted on their mounting rim in order to be fitted to the front axle and the rear axle of this vehicle, the tires of the rear axle having grooves the mean depths of which are at least equal to 3 mm and at most equal to 5 mm, the tires of the front axle having grooves the mean depths of which are greater than 5 mm, this road-going assembly having, at least in the case of the rear axle, static setups (camber, toe-in) of close to zero, that is to say a camber of each wheel-tire assembly on the said axle of between −0.8 degrees and +0.8 degrees and a toe-in at each wheel of between −0.15 degrees and +0.15 degrees, the static setups of the tires of one and the same axle being equal in terms of absolute value and symmetric with respect to a plane perpendicular to the road surface.

    摘要翻译： 由包括前轴和后轴的车辆以及安装在其安装轮辋上的一组轮胎组成的行驶组件以便安装到该车辆的前轴和后桥上，轮胎 所述后桥具有凹槽，所述凹槽的平均深度至少等于3mm并且至多等于5mm，所述前轴的轮胎具有平均深度大于5mm的凹槽，所述道路组件具有 至少在后桥的情况下，静态设置（弧度，脚趾）接近零，也就是所述车轮上的每个车轮轮胎组件的弯度在-0.8度和+0.8度之间 并且在每个车轮上的脚趾在-0.15度至+0.15度之间，同一轴的轮胎的静态设置在绝对值方面是相等的，并且相对于垂直于路面的平面是对称的。

    COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT
    8.
    发明申请
    COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT 审中-公开
    抗HIV治疗期间使用的组合物和方法

    公开(公告)号：US20110046091A1

    公开(公告)日：2011-02-24

    申请号：US12811474

    申请日：2008-12-31

    申请人： Pierre Cau ,  Patrice Bourgeois ,  Vincent Bonniol ,  Nicolas Levy

    发明人： Pierre Cau ,  Patrice Bourgeois ,  Vincent Bonniol ,  Nicolas Levy

    IPC分类号： A61K31/663 ,  A61P31/18

    CPC分类号： A61K31/675 ,  A61K31/215 ,  A61K31/22 ,  A61K31/366 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/496 ,  A61K31/66 ,  A61K31/665 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention relates to a composition comprising an anti-HIV treatment and a treatment for side effects of said anti-HIV treatment in an HIV-infected patient. This invention is, for example, very useful in the treatment of side effects caused by certain anti-HIV treatments, for example premature aging and lipodystrophy, which can be caused by protease inhibitors or reverse transcriptase inhibitors. The composition of this invention includes at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, at least one farnesyl-pyrophosphate synthase inhibitor, and at least one anti-HIV agent. One of the processes for treating an HIV-infected patient includes, in any order, the following steps: (i) administration of a mixture including at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and at least one farnesyl-pyrophosphate synthase inhibitor and (ii) administration of an anti-HIV agent, in which the administrations are concomitant, successive or alternative.

    摘要翻译： 本发明涉及包含抗HIV治疗和在HIV感染患者中所述抗HIV治疗的副作用的治疗的组合物。 本发明例如在治疗由某些抗HIV治疗引起的副作用（例如可能由蛋白酶抑制剂或逆转录酶抑制剂引起的过早衰老和脂肪营养不良）非常有用。 本发明的组合物包括至少一种羟甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，至少一种法呢基焦磷酸合酶抑制剂和至少一种抗HIV剂。 用于治疗HIV感染患者的方法之一包括以下任一顺序：（i）施用包含至少一种羟甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂和至少一种法呢基焦磷酸盐 合成酶抑制剂和（ii）施用抗HIV药物，其中给药是伴随的，连续的或替代的。