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19 条记录 (耗时 0.03 秒)

    Method of inducing anergic T helper cells
    1.
    发明授权
    Method of inducing anergic T helper cells 失效
    诱导无能的T辅助细胞的方法

    公开(公告)号：US07144728B1

    公开(公告)日：2006-12-05

    申请号：US10018677

    申请日：2000-06-15

    申请人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    发明人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    IPC分类号： C12N5/00 ,  C12N5/08 ,  C12N5/02 ,  C12N15/85

    CPC分类号： G01N33/56972 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/124 ,  A61K2039/5156 ,  C12N2510/00

    摘要： This invention also provides a method of generating antigen specific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28− T cells. Methods of tent for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28− T cells so produced are also provided, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.

    摘要翻译： 本发明还提供了产生抗原特异性人抑制剂CD8 + CD28-T细胞的方法。 本发明还提供了产生抗原特异性抗体抑制剂CD8 + CD28-T细胞的方法。 还提供了使用如此产生的人抑制剂CD8 + CD28-T细胞降低同种异体移植物和异种移植物和自身免疫疾病排斥风险的帐篷的方法，以及预防排斥反应和自身免疫性疾病的方法以及包含所产生的抑制性T细胞的疫苗 。 提供诊断方法以确定免疫抑制剂治疗水平是否需要减少。

    Methods for generating tolerogenic antigen presenting cells
    2.
    发明授权
    Methods for generating tolerogenic antigen presenting cells 失效
    产生耐受性抗原呈递细胞的方法

    公开(公告)号：US06759239B2

    公开(公告)日：2004-07-06

    申请号：US09746311

    申请日：2000-12-21

    申请人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    发明人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    IPC分类号： C12N500

    CPC分类号： G01N33/56972 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/124 ,  A61K2039/5156 ,  C12N2510/00

    摘要： This invention provides a method of generating antigen specific allospecific human suppressor CD8+CD28− T cells. This invention also provides a method of generating xenospecific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28− T cells. Methods of treatment for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28− T cells so produced are also provides, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.

    摘要翻译： 本发明提供了产生抗原特异性异体人抑制因子CD8 + CD28-T细胞的方法。 本发明还提供了产生异种人抑制CD8 + CD28-T细胞的方法。 本发明还提供了产生抗原特异性抗体抑制剂CD8 + CD28-T细胞的方法。 使用如此产生的人抑制剂CD8 + CD28-T细胞降低同种异体移植物和异种移植物和自身免疫疾病排斥风险的治疗方法也提供了预防排斥反应和自身免疫性疾病的方法以及包含所产生的抑制性T细胞的疫苗 。 提供诊断方法以确定免疫抑制剂治疗水平是否需要减少。

    ILT3 and ILT4-related compositions and methods
    3.
    发明申请
    ILT3 and ILT4-related compositions and methods 审中-公开
    ILT3和ILT4相关的组合物和方法

    公开(公告)号：US20090280109A1

    公开(公告)日：2009-11-12

    申请号：US12072119

    申请日：2008-02-22

    申请人： Nicole Suciu-Foca ,  Zhuoru Liu ,  Chih-Chao Chang ,  Raffaello Cortesini

    发明人： Nicole Suciu-Foca ,  Zhuoru Liu ,  Chih-Chao Chang ,  Raffaello Cortesini

    IPC分类号： A61K39/395

    CPC分类号： A61K31/593 ,  A61K35/15 ,  A61K35/17 ,  A61K38/2066 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K2035/122 ,  A61K2039/505 ,  A61K2039/5154 ,  C12N5/064 ,  C12N2500/38 ,  C12N2501/23 ,  C12N2502/11 ,  G01N33/564 ,  A61K2300/00

    摘要： This invention provides compositions which comprise at least two of a CD4+CD25+ cell, IL-10, a CD8+CD28− cell and a vitamin D3 analog. This invention also provides methods for generating a tolerogenic antigen-presenting cell, and increasing the expression of ILT3 and/or ILT4 by an antigen-presenting cell. This invention further provides methods for inhibiting the onset of or treating the rejection of an antigenic substance and inhibiting the onset of or treating an autoimmune disease in a subject. This invention further provides methods for treating and preventing AIDS, cancer, and Hepatitis C-related disorders, and for identifying agents useful for such purposes. Finally, this invention provides related compositions and kits.

    摘要翻译： 本发明提供了包含CD4 + CD25 +细胞，IL-10，CD8 + CD28-细胞和维生素D3类似物中的至少两种的组合物。 本发明还提供了产生耐受性抗原呈递细胞的方法，并且通过抗原呈递细胞增加ILT3和/或ILT4的表达。 本发明还提供了抑制受试者的抗原性物质的排斥或抑制自身免疫性疾病的发生或治疗的方法。 本发明还提供了用于治疗和预防艾滋病，癌症和丙型肝炎相关疾病以及用于鉴定用于此目的的药剂的方法。 最后，本发明提供了相关的组合物和试剂盒。

    Generation of antigen specific T suppressor cells for treatment of rejection
    4.
    发明申请
    Generation of antigen specific T suppressor cells for treatment of rejection 审中-公开
    产生用于治疗排斥反应的抗原特异性T抑制细胞

    公开(公告)号：US20050250161A1

    公开(公告)日：2005-11-10

    申请号：US10884730

    申请日：2004-07-02

    申请人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    发明人： Nicole Suciu-Foca ,  Raffaello Cortesini ,  Zhuoru Liu ,  Chih-Chao Chang

    IPC分类号： A61K35/12 ,  A61K39/00 ,  C12N5/02 ,  C12N5/08 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  G01N33/569

    CPC分类号： G01N33/56972 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/124 ,  A61K2039/5156 ,  C12N2510/00

    摘要： This invention provides a method of generating antigen specific allospecific human-suppressor CD8+CD28− T cells. This invention also provides a method of generating xenospecific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28− T cells. Methods of treatment for, reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28− T cells so produced are also provides, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.

    摘要翻译： 本发明提供了产生抗原特异性同种异体人抑制CD8 + CD28-T细胞的方法。 本发明还提供了产生异种人抑制CD8 + CD28-T细胞的方法。 本发明还提供了产生抗原特异性抗体抑制剂CD8 + CD28-T细胞的方法。 还使用如此产生的人抑制剂CD8 + CD28-T细胞减少同种异体移植物和异种移植物排斥风险和自身免疫性疾病的方法，以及预防排斥反应和自身免疫疾病的方法以及包含产生的抑制剂T的疫苗 细胞。 提供诊断方法以确定免疫抑制剂治疗水平是否需要减少。

    SOCKET REMOVABLY ATTACHED TO A TOOL AND HAVING DRIVING PROTRUSIONS
    8.
    发明申请
    SOCKET REMOVABLY ATTACHED TO A TOOL AND HAVING DRIVING PROTRUSIONS 有权

    公开(公告)号：US20210205963A1

    公开(公告)日：2021-07-08

    申请号：US17207724

    申请日：2021-03-21

    申请人： Yao-Lin Cho ,  Zi-Yan Huang ,  Chih-Chao Chang

    发明人： Yao-Lin Cho ,  Zi-Yan Huang ,  Chih-Chao Chang

    IPC分类号： B25B13/06 ,  B25B23/00 ,  B25B23/10

    摘要： A socket is portably and removably attached to a tool and includes a body with a mounting hole which includes multiple faces. Each face includes a first protrusion and two groups of second protrusions located on two sides of the first protrusion. The first protrusion of each face includes a first flat distal surface which has a certain length. Each second protrusion includes a second flat distal surface which is tilt relative to the first flat distal surface. The two respective slopes of the second flat distal surfaces of the two groups of the second protrusions are opposite to each other. A first imaginary plane is co-linear with the first flat distal surface. A second imaginary plane is co-linear with the second flat distal surfaces of each second protrusion. An angle is formed between the first and second imaginary planes. The socket can drive a normal or rounded bolt.

    CAPACITIVE TOUCH PANEL AND GHOST POINT DETERMINATION METHOD
    9.
    发明申请
    CAPACITIVE TOUCH PANEL AND GHOST POINT DETERMINATION METHOD 审中-公开
    电容触摸屏和贪心点确定方法

    公开(公告)号：US20110291984A1

    公开(公告)日：2011-12-01

    申请号：US12853311

    申请日：2010-08-10

    申请人： Chih-Chao Chang ,  Chao-Yong Hsu ,  Shin-Chung Huang ,  Yi-Nan Chu

    发明人： Chih-Chao Chang ,  Chao-Yong Hsu ,  Shin-Chung Huang ,  Yi-Nan Chu

    IPC分类号： G06F3/045

    CPC分类号： G06F3/044 ,  G06F3/0416 ,  G06F2203/04104

    摘要： A capacitive touch panel and a ghost point determination method are provided. The capacitive touch panel includes a touch sensing plate and a touch sensing module. The touch sensing plate includes a plurality of sensing units. The sensing units are disposed along a first direction and a second direction to from an array. Capacitance values of the sensing units are decreased gradually along the first direction. The touch sensing module is coupled to the touch sensing plate for sensing at least two real touch points.

    摘要翻译： 提供了电容式触摸面板和鬼点确定方法。 电容式触摸面板包括触摸感测板和触摸感测模块。 触摸感测板包括多个感测单元。 感测单元沿着第一方向和第二方向设置成从阵列。 感测单元的电容值沿着第一方向逐渐减小。 触摸感测模块耦合到触摸感测板，用于感测至少两个实际触摸点。

    SOCKET
    10.
    发明申请
    SOCKET 有权

    公开(公告)号：US20210086331A1

    公开(公告)日：2021-03-25

    申请号：US17115800

    申请日：2020-12-09

    申请人： Kuo-Cheng Wu ,  Chih-Chao Chang

    发明人： Kuo-Cheng Wu ,  Chih-Chao Chang

    IPC分类号： B25B13/06

    摘要： A socket includes multiple protrusions and grooves alternatively formed in the inner periphery of the central hole of the socket. Each protrusion has an encounter face formed on the distal end thereof. The encounter face includes two inclined faces which intersect at a peak point by a top angle. Each protrusion includes two lateral sides which respectively face the grooves corresponding thereto. The two inclined faces respectively intersect the two lateral sides at a corner by a corner angle which is an obtuse angle. An angle of 2 to 9 degrees is defined between each of the inclined face and a chord that passes the peak point and is perpendicular to an axis of the protrusion. The center angle between the two lateral sides of each protrusion is 25 to 44 degrees. The socket effectively drives rounded object and the corners of each protrusions are not damaged.