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公开(公告)号:US20100137365A1
公开(公告)日:2010-06-03
申请号:US12656370
申请日:2010-01-28
申请人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号: A61K31/445 , A61P31/12 , A61P31/14 , C07D211/46 , C07D207/12 , C07C237/42 , A61K31/402 , A61K31/166
CPC分类号: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译: 描述了长链N-烷基氨基和亚氨基化合物,其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染,特别是乙型肝炎病毒或丙型肝炎病毒。 例如,长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶,吡咯烷,苯胺,吡啶,吡咯或氨基酸。
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公开(公告)号:US07816560B1
公开(公告)日:2010-10-19
申请号:US10031145
申请日:2000-08-10
申请人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号: C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译: 描述了长链N-烷基氨基和亚氨基化合物,其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染,特别是乙型肝炎病毒或丙型肝炎病毒。 例如,长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶,吡咯烷,苯胺,吡啶,吡咯或氨基酸。
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公开(公告)号:US09089515B2
公开(公告)日:2015-07-28
申请号:US13064116
申请日:2011-03-07
申请人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号: A61K31/45 , A61P31/12 , A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445
CPC分类号: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译: 描述了长链N-烷基氨基和亚氨基化合物,其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染,特别是乙型肝炎病毒或丙型肝炎病毒。 例如,长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶,吡咯烷,苯胺,吡啶,吡咯或氨基酸。
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公开(公告)号:US20110184019A1
公开(公告)日:2011-07-28
申请号:US13064116
申请日:2011-03-07
申请人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人: Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
CPC分类号: A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译: 描述了长链N-烷基氨基和亚氨基化合物,其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染,特别是乙型肝炎病毒或丙型肝炎病毒。 例如,长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶,吡咯烷,苯胺,吡啶,吡咯或氨基酸。
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公开(公告)号:US06465487B1
公开(公告)日:2002-10-15
申请号:US09209033
申请日:1998-12-10
申请人: Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
发明人: Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
IPC分类号: A61K31445
CPC分类号: A61K31/00 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
摘要翻译: 抑制宿主细胞膜出芽病毒的形态发生和由此引起的感染的方法使用抑制宿主细胞葡糖苷酶或葡糖基转移酶的化合物的方法。 使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。
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公开(公告)号:US08367705B2
公开(公告)日:2013-02-05
申请号:US12813882
申请日:2010-06-11
IPC分类号: A61K31/445
摘要: Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
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公开(公告)号:US08450345B2
公开(公告)日:2013-05-28
申请号:US12656992
申请日:2010-02-22
IPC分类号: A61K31/445 , A61P31/20
CPC分类号: A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
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公开(公告)号:US20110065752A1
公开(公告)日:2011-03-17
申请号:US12873704
申请日:2010-09-01
IPC分类号: A61K31/445 , A61P31/14 , C12N5/02
CPC分类号: A61K31/445 , A61K31/655 , C07D211/46
摘要: Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译: 提供了新的亚氨基糖苷以及使用亚氨基二糖如DNJ衍生物治疗和/或预防由属于正粘病毒科的病毒引起或与之相关的疾病或病症的方法。
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公开(公告)号:US20100222384A1
公开(公告)日:2010-09-02
申请号:US12656993
申请日:2010-02-22
IPC分类号: A61K31/445 , A61P31/12
CPC分类号: A61K31/445
摘要: Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Arenaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译: 本发明提供了使用亚氨基二糖(例如DNJ衍生物)治疗由属于该病毒属(Arenaviridae)家族的病毒引起或与之相关的疾病或病症的方法。
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公开(公告)号:US20110065753A1
公开(公告)日:2011-03-17
申请号:US12873705
申请日:2010-09-01
IPC分类号: A61K31/445 , A61P31/20 , C12N5/02
CPC分类号: A61K31/445 , A61K31/452 , C07D211/46
摘要: Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Poxyiridae family using iminosugars, such as DNJ derivatives.
摘要翻译: 本发明提供了使用亚氨基糖类(例如DNJ衍生物)治疗由属于Poxyiridae家族的病毒引起或与之有关的疾病或病症的方法。
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