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公开(公告)号:US20120065183A1
公开(公告)日:2012-03-15
申请号:US13175050
申请日:2011-07-01
申请人: Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
发明人: Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
IPC分类号: A61K31/519 , A61K31/5377 , A61P19/02 , A61P17/00 , A61P37/08 , A61P7/06 , A61P25/00 , A61P21/04 , A61P35/00 , C07D471/04 , A61P7/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US20140128370A1
公开(公告)日:2014-05-08
申请号:US14151796
申请日:2014-01-09
申请人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
发明人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US20170267678A1
公开(公告)日:2017-09-21
申请号:US15613560
申请日:2017-06-05
申请人: Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人: Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号: C07D471/04 , A61K31/519 , A61K31/5377
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号:US20170022199A1
公开(公告)日:2017-01-26
申请号:US15285614
申请日:2016-10-05
申请人: Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人: Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/519
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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