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公开(公告)号:US20170020819A1
公开(公告)日:2017-01-26
申请号:US15217098
申请日:2016-07-22
发明人: Roger Adami , Yuwei Wang , Haiqing Ying , Liping Wang , Dong Liu , Wenbin Ying
IPC分类号: A61K9/19 , C12N15/113 , A61K9/14
CPC分类号: A61K9/19 , A61K9/145 , A61K9/146 , A61K47/26 , A61K47/36 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
摘要翻译: 本发明提供用于制备一种或多种核酸活性剂的固体冻干物的组合物,其可以重构为药物产品。 所述组合物可以包括在药学上可接受的溶液中的脂质纳米颗粒的水性悬浮液,其中所述脂质纳米颗粒包封一种或多种核酸活性剂,糊精化合物和糖类化合物。 核酸活性剂可以是能够介导RNA干扰的RNAi分子,以及其它RNA和寡核苷酸。
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公开(公告)号:US20160376229A1
公开(公告)日:2016-12-29
申请号:US15191511
申请日:2016-06-23
发明人: Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Ying , Wenbin Ying
IPC分类号: C07C271/16 , A61K47/22 , C07D207/12 , A61K47/16 , C07C237/16 , A61K31/713 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K47/24 , C07D205/04 , C07D207/09
CPC分类号: C07C271/16 , A61K9/127 , A61K9/5123 , A61K31/7105 , A61K31/713 , C07C237/08 , C07C237/16 , C07C237/50 , C07D205/04 , C07D207/09 , C07D207/12 , C07D211/74 , C07D211/82 , C07D211/86 , C07F9/06 , C07F9/106 , A61K2300/00
摘要: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
摘要翻译: 本发明包括可离子化的化合物及其组合物及其使用方法。 可电离化合物可用于制备用于生物药物和治疗剂的纳米颗粒组合物。 更具体地说,本发明涉及用于提供纳米颗粒以包封活性剂(例如核酸试剂)的化合物,组合物和方法,并将活性剂递送和分配到细胞,组织,器官和受试者中。
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