公开(公告)号：US20190127318A1

公开(公告)日：2019-05-02

申请号：US16228054

申请日：2018-12-20

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: C07C271/16 ,  A61K31/713 ,  C07F9/10 ,  C07D211/82 ,  C07D211/86 ,  C07D207/09 ,  C07D207/12 ,  C07D205/04 ,  C07F9/06 ,  C07C237/16 ,  C07C237/50 ,  C07C237/08 ,  A61K9/51 ,  A61K9/127 ,  A61K47/22 ,  A61K47/16 ,  A61K47/24 ,  A61K31/7105 ,  C07D211/74

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US09636411B2

公开(公告)日：2017-05-02

申请号：US14786841

申请日：2013-04-26

Applicant: NITTO DENKO CORPORATION

Inventor： Hao Bai ,  Kwok Yin Tsang ,  Yi Jin ,  Lei Yu

IPC: C08G63/02 ,  A61K47/48 ,  C08G69/10 ,  C08G73/02 ,  C08G64/00

CPC classification number: A61K47/48207 ,  A61K47/645 ,  C08G69/10 ,  C08G73/028

Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

公开(公告)号：US20220242820A1

公开(公告)日：2022-08-04

申请号：US17658075

申请日：2022-04-05

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: C07C271/16 ,  C07D205/04 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  A61K31/713 ,  C07F9/10 ,  A61K31/7105 ,  A61K9/127 ,  A61K9/51 ,  C07C237/08 ,  C07C237/50 ,  A61K47/16 ,  A61K47/22 ,  A61K47/24

Abstract: Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US11384051B2

公开(公告)日：2022-07-12

申请号：US16228054

申请日：2018-12-20

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: A61K31/713 ,  A61K31/7105 ,  A61K9/127 ,  A61K9/51 ,  A61K47/16 ,  A61K47/22 ,  A61K47/24 ,  C07C271/16 ,  C07D205/04 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  C07F9/10 ,  C07C237/08 ,  C07C237/50

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US10167253B2

公开(公告)日：2019-01-01

申请号：US15191511

申请日：2016-06-23

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: A61K47/16 ,  A61K31/17 ,  A61K47/18 ,  C07C271/16 ,  C07D205/04 ,  A61K47/22 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  A61K47/24 ,  A61K31/713 ,  C07F9/10 ,  A61K31/7105

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US10080737B2

公开(公告)日：2018-09-25

申请号：US14679404

申请日：2015-04-06

Applicant: Nitto Denko Corporation

Inventor： Wenbin Ying ,  Kwok Yin Tsang ,  Hao Bai ,  Haiqing Yin ,  Jihua Liu ,  Li Wang

IPC: A61K47/48 ,  A61K31/337 ,  A61K31/395 ,  C08G69/48 ,  C08G69/10 ,  A61K47/64

CPC classification number: A61K31/395 ,  A61K31/337 ,  A61K47/645 ,  C08G69/10 ,  C08G69/48

Abstract: Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

公开(公告)号：US20160074524A1

公开(公告)日：2016-03-17

申请号：US14786841

申请日：2013-04-26

Applicant: NITTO DENKO CORPORATION

Inventor： Hao Bai ,  Kwok Yin Tsang ,  Yi Jin ,  Lei Yu

IPC: A61K47/48 ,  C08G73/02

CPC classification number: A61K47/48207 ,  A61K47/645 ,  C08G69/10 ,  C08G73/028

Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Abstract translation: 本文描述了制备生物相容性水溶性聚合物共轭物的方法。 特别地，本文描述了可用于各种药物递送应用的制备聚（L-γ-谷氨酸 - 谷氨酸）共轭物的大规模方法。

公开(公告)号：US11413243B2

公开(公告)日：2022-08-16

申请号：US16182571

申请日：2018-11-06

Applicant: Nitto Denko Corporation

Inventor： Kwok Yin Tsang ,  Bharat Majeti ,  John Gaudette ,  Roger Adami ,  Hao Bai ,  Wenbin Ying

IPC: A61K9/127 ,  A61K47/10 ,  A61K47/69 ,  A61K31/7105 ,  A61K47/14 ,  C07C201/00 ,  B82Y5/00

Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US09839694B2

公开(公告)日：2017-12-12

申请号：US14786729

申请日：2013-04-26

Applicant: NITTO DENKO CORPORATION

Inventor： Kwok Yin Tsang ,  Hao Bai ,  Yi Jin ,  Lei Yu

IPC: C08G69/00 ,  A61K47/48 ,  A61K31/337 ,  C08G69/10 ,  C08G69/46 ,  C08G69/48 ,  A61K47/59 ,  A61K47/64

CPC classification number: A61K47/645 ,  A61K31/337 ,  A61K47/595 ,  C08G69/10 ,  C08G69/46 ,  C08G69/48

Abstract: Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

公开(公告)号：US20130272993A1

公开(公告)日：2013-10-17

申请号：US13790995

申请日：2013-03-08

Applicant: NITTO DENKO CORPORATION

Inventor： Kwok Yin Tsang ,  Hai Wang ,  Hao Bai ,  Yi Jin ,  Lei Yu

IPC: A61K47/48

CPC classification number: A61K47/48207 ,  A61K47/645 ,  A61K49/146 ,  C08G69/10

Abstract: This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.

Abstract translation: 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。