公开(公告)号：US20190231712A1

公开(公告)日：2019-08-01

申请号：US16262391

申请日：2019-01-30

Applicant: NITTO DENKO CORPORATION

Inventor： Chie MATSUMOTO ,  Tomohito TAKITA ,  Kaiji FUJIWARA ,  Akinori SUGIYAMA ,  Tomoya TANAKA

IPC: A61K9/70 ,  A61K47/12 ,  A61K47/18 ,  A61K31/197 ,  A61K47/32 ,  A61K47/38 ,  A61K47/36

CPC classification number: A61K9/7084 ,  A61K9/7023 ,  A61K31/197 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

Abstract: Provided is a transdermal absorption preparation having superior drug skin permeability, which can uniformly disperse the drug in the preparation and maintain the uniform dispersion state of the drug.A transdermal absorption preparation having a plaster layer containing a drug, a polymer and a pH adjuster, in which the aforementioned polymer contains a polymer having a particular glass transition temperature of 30° C.-200° C., and the surface of the plaster layer has a pH of 6.7-10.0.

公开(公告)号：US20180311363A1

公开(公告)日：2018-11-01

申请号：US15935568

申请日：2018-03-26

Applicant: Nitto Denko Corporation

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/135

CPC classification number: A61K31/135 ,  A61K9/703 ,  A61K9/7061

Abstract: A transdermal absorption preparation precursor 50 containing a release liner 10 containing one first valley fold part 1, one or two first mountain fold parts 2, and a first base line L1 and a second base line L2 on one side and the other side apart from the first valley fold part 1 as a line of demarcation and at an approximately equal distance from the first valley fold part 1, wherein at least one of the first base line L1 and the second base line L2 is a fold line of the first mountain fold part 2, and a drug-containing layer 3 having a center line laid on the first base line L1 and an adhesive layer 4 having a center line laid on the second base line L2 on the release liner 10.

公开(公告)号：US20190290596A1

公开(公告)日：2019-09-26

申请号：US16354275

申请日：2019-03-15

Applicant: NITTO DENKO CORPORATION

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO ,  Akinori SUGIYAMA ,  Jyun ISAYAMA ,  Toshinari HONDA ,  Ai FUNASAKI

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/385

Abstract: Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:(1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.

公开(公告)号：US20180311362A1

公开(公告)日：2018-11-01

申请号：US15935443

申请日：2018-03-26

Applicant: Nitto Denko Corporation

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/137 ,  A61K31/135

CPC classification number: A61K9/7061 ,  A61K9/7053 ,  A61K31/135 ,  A61K31/137

Abstract: Provided is a transdermal absorption preparation that shows superior skin permeability of a drug and that does not easily cause cold flow.A transdermal absorption preparation having a drug-containing layer containing a drug and a polymer, wherein 50-100 wt % of the polymer in the drug-containing layer is a polymer having a glass transition temperature of 30° C.-200° C., and the drug in the drug-containing layer is in an amorphous state.