摘要:
Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.
摘要翻译:本发明提供了含有由式(I)表示的含氮杂环化合物的犬尿氨酸生产抑制剂:其中R50和R51可以相同或不同,各自表示氢原子等,G1和G2可以相同或不同 各自表示氮原子等,X表示式(III):(其中,m1和m2可以相同或不同,表示0或1的整数,Y表示氧原子等,R6和 R 7可以相同或不同,各自表示氢原子等),R 1表示任选取代的低级烷基等,R 2表示氢原子等,R 3表示任选取代的低级烷基等),和 类似。
摘要:
Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.
摘要翻译:本发明提供了含有由式(I)表示的含氮杂环化合物的犬尿氨酸生产抑制剂:其中R50和R51可以相同或不同,各自表示氢原子等,G1和G2可以相同或不同 各自表示氮原子等,X表示式(III):(其中,m1和m2可以相同或不同,表示0或1的整数,Y表示氧原子等,R6和 R 7可以相同或不同,各自表示氢原子等),R 1表示任选取代的低级烷基等,R 2表示氢原子等,R 3表示任选取代的低级烷基等),和 类似。
摘要:
The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or —CH—; X represents —C(═O)— or —CHR4— (wherein R4 represents a hydrogen atom, or the like}; R1 represents a group represented by the following formula: [wherein Q1 represents a nitrogen atom or —CR8— (wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). Q2 represents —NR15— (wherein R15 represents a hydrogen atom, or the like) and R5 and R6 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like]; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof, and the like.
摘要:
The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or —CH—; X represents —C(═O)— or —CHR4— (wherein R4 represents a hydrogen atom, or the like); R1 represents a group represented by the following formula: [wherein Q1 represents a nitrogen atom or —CR8— (wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). Q2 represents —NR15— (wherein R15 represents a hydrogen atom, or the like) and R5 and R6 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like]; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof, and the like.
摘要:
The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).
摘要翻译:本发明提供对由式(I)表示的对犬尿胆碱的产生具有抑制作用的含氮杂环化合物或其药学上可接受的盐:(其中R 6和R 7可以相同或不同,各自表示氢原子 R 8,R 19和R 11可以相同或不同,各自表示氢原子等,R 1表示可被环烷基取代的低级烷基等,R 3表示任意取代的芳基或 任选取代的杂环基)。
摘要:
A grip member with an electric heater, in which the surface of a core body when a heater is installed is flat. A metal conductive plate, such as a SUS plate with a thickness of about 30 μm formed in a belt-like shape, is spirally embedded along a flat groove section provided in a core body, the surface of the core body is made flat, and the metal conductive plate is fixed at both ends to the core body. An electric current is passed through the metal conductive plate to cause it to generate heat.
摘要:
A handle grip member with electric heater can be produced in high yield through simple processing not using any core of synthetic resin and avoiding molding operation. Depressed groove (4) is spirally provided on an external surface of inner part (1) of rubber, and multiple ribs (5) are provided on an internal surface thereof along the direction of length. Electric heater (7) of tape-shaped metal conductor is implanted in the depressed groove (4), and fixed. Electric wires (8a,8b) are connected to two ends of the electric heater (7) and drawn out. The inner part (1) is inserted in outer part (9) of rubber tube, and the outer part (9) is fixed to the inner part (1) with the use of an adhesive, etc.
摘要:
A cleaning device includes a cleaning blade member that has a tip abutting a surface of an image carrier so as to remove a residue remaining on the surface of the image carrier; an attaching member that includes a first attachment piece to which a base end of the cleaning blade member is attached, and a second attachment piece which is provided so as to intersect the first attachment piece at a predetermined angle; a housing member to which one of the first attachment piece and the second attachment piece is fixed at both ends along a longitudinal direction thereof; and an external force exerting member that exerts an external force in a direction which intersects a surface of the other one of the first attachment piece and the second attachment piece, which is not fixed to the housing member.
摘要:
A fixing device includes: a belt member provided to be circularly movable having a width; a first fixing member disposed inside the belt member; a second fixing member disposed in press contact with the first fixing member across the belt member, and forms a passing portion with the belt member, through which a recording medium passes; and a pressing member disposed along a width direction of the belt member and downstream of the passing portion in a moving direction of the belt member, in which the pressing member has a surface and brings the surface in contact with an inner peripheral surface of the belt member to press the belt member against the second fixing member. The surface is curved toward the second fixing member along with a move from an end portion to a center portion in a longitudinal direction of the pressing member.
摘要:
A magnestostrictive torque sensor detects rotating torque applied to a rod-shaped rotating shaft to work around the rotating shaft based on a change in magnetic characteristics of a magnetostrictive film formed on a surface the rotating shaft so as to extend around a full circumference thereof in a circumferential direction. The magnetostrictive film is formed continuously in an axial direction at a portion on the rotating shaft in the axial direction thereof. The magnetostrictive film has on the continuously formed area a first magnetostrictive film portion and a second magnetostrictive film portion having magnetic anisotropies which are opposite to each other and a third magnetostrictive film portion which is formed between the first and second magnetostrictive film portions. A first detection coil, a second detection coil and a third detection coil are provided for the first magnetostrictive film portion, the second magnetostrictive film portion and the third magnetostrictive film portion, respectively.