公开(公告)号：US20090073554A1

公开(公告)日：2009-03-19

申请号：US11913833

申请日：2006-05-16

申请人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

发明人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

IPC分类号： G02B21/06

CPC分类号： G02B21/002 ,  G02B21/008 ,  G02B21/365

摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.

摘要翻译： 提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于 控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

公开(公告)号：US07804642B2

公开(公告)日：2010-09-28

申请号：US11913833

申请日：2006-05-16

申请人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

发明人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

IPC分类号： G02B21/06

CPC分类号： G02B21/002 ,  G02B21/008 ,  G02B21/365

摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.

摘要翻译： 提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于 控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

公开(公告)号：US20050094296A1

公开(公告)日：2005-05-05

申请号：US10975882

申请日：2004-10-28

申请人： Kenzi Murakami ,  Yoshitaka Kamiya ,  Hiroshi Miyajima ,  Yujin Arai

发明人： Kenzi Murakami ,  Yoshitaka Kamiya ,  Hiroshi Miyajima ,  Yujin Arai

IPC分类号： B81B3/00 ,  G02B26/10 ,  G02B26/08 ,  G02B5/08 ,  G02B7/182

CPC分类号： G02B26/105

摘要： A light deflector comprises a first movable plate having a reflective surface, fixing portions, a pair of second movable plates located between the first movable plate and the fixing portions, a pair of first elastic members supporting the first movable plate so as to allow it to oscillate with respect to the second movable plates, a pair of second elastic members supporting the second movable plates so as to allow them to oscillate with respect to the fixing portions, and an actuator to oscillate the first movable plate. Oscillation axis of the first elastic members and oscillation axis of the second elastic members are located on the same axis. Stiffness of the second elastic members against oscillation is lower than stiffness of the first elastic members against oscillation.

摘要翻译： 光偏转器包括具有反射表面的第一可移动板，固定部分，位于第一可移动板和固定部分之间的一对第二可动板，支撑第一可移动板的一对第一弹性元件， 相对于第二可移动板振荡;一对第二弹性部件，其支撑第二可移动板，以使它们相对于固定部分摆动;以及致动器，使第一可移动板振荡。 第一弹性部件的摆动轴和第二弹性部件的摆动轴位于同一轴线上。 第二弹性构件相对于振动的刚度低于第一弹性构件相对于振动的刚度。

公开(公告)号：US07869706B2

公开(公告)日：2011-01-11

申请号：US12327859

申请日：2008-12-04

申请人： Takeshi Minamide ,  Yujin Arai

发明人： Takeshi Minamide ,  Yujin Arai

IPC分类号： G02B21/36 ,  G02B23/00 ,  G02B7/04 ,  G02B27/64 ,  G06K9/40

CPC分类号： G02B21/365

摘要： A camera head acquires a sample image by shooting a scaled up image of a sample obtained by a microscope body. A memory device records the sample image in a record medium. A CPU detects the completion of the sighting on an observed portion of a sample in a microscope body on the basis of a R. G. B data value of each pixel configuring a microscope image detected by the R. G. B data value. Furthermore, the CPU detects the completion of the focusing on the observed portion by the microscope boundary on the basis of the height of the contrast of the microscope image detected by the focusing completion detection unit. When both completion of the sighting and completion of focusing are detected, the CPU controls a memory device to record a sample image acquired by a camera head on a record medium.

摘要翻译： 相机头通过拍摄由显微镜主体获得的样本的放大图像来获取样本图像。 存储器件将样品图像记录在记录介质中。 CPU根据构成由R.G.B数据值检测到的显微镜图像的每个像素的R.G.B数据值来检测显微镜主体中的观察部分的观察完成。 此外，CPU基于由聚焦完成检测单元检测到的显微镜图像的对比度的高度，通过显微镜边界检测对观察部分的聚焦的完成。 当检测到瞄准和完成聚焦的两者完成时，CPU控制存储装置将由相机头获取的样本图像记录在记录介质上。

公开(公告)号：US20060017006A1

公开(公告)日：2006-01-26

申请号：US11185374

申请日：2005-07-20

申请人： Nobuhiro Takamizawa ,  Yujin Arai

发明人： Nobuhiro Takamizawa ,  Yujin Arai

IPC分类号： G01N21/64

CPC分类号： G01N21/6458

摘要： A laser scanning microscope enables an observation of a specimen through emitting a laser beam onto the specimen marked by a plurality of fluorescent probes and receiving a fluorescent light back from the specimen corresponding to the emission, and comprises a laser source for generating a laser beam in an excitation wavelength corresponding to the plurality of fluorescent probes, a deflector unit for scanning the generated laser beam over an observation plane of the specimen, a dispersion unit for dispersing a fluorescent light from the specimen to extract it by an arbitrary wavelength interval, a spectral data acquisition condition setting unit for setting a condition for the dispersion unit acquiring a spectral data based on spectrum characteristics of the plurality of fluorescent probes, a dispersion control unit for controlling the dispersion unit based on the set spectral data acquisition condition.

摘要翻译： 激光扫描显微镜能够通过将激光束发射到由多个荧光探针标记的样品上并从对应于发射的样品接收荧光的方式观察样品，并且包括用于产生激光束的激光源 对应于多个荧光探针的激发波长，用于在所述检体的观察平面上扫描产生的激光束的偏转器单元，用于分散来自所述样本的荧光以将其提取任意波长间隔的色散单元，光谱 数据获取条件设置单元，用于根据所述多个荧光探针的频谱特性设置所述色散单元获取光谱数据的条件;色散控制单元，用于基于所设定的光谱数据获取条件来控制所述色散单元。

公开(公告)号：US20090148153A1

公开(公告)日：2009-06-11

申请号：US12327859

申请日：2008-12-04

申请人： Takeshi MINAMIDE ,  Yujin Arai

发明人： Takeshi MINAMIDE ,  Yujin Arai

IPC分类号： G02B21/36

CPC分类号： G02B21/365

摘要： A camera head acquires a sample image by shooting a scaled up image of a sample obtained by a microscope body. A memory device records the sample image in a record medium. A CPU detects the completion of the sighting on an observed portion of a sample in a microscope body on the basis of a R. G. B data value of each pixel configuring a microscope image detected by the R. G. B data value. Furthermore, the CPU detects the completion of the focusing on the observed portion by the microscope boundary on the basis of the height of the contrast of the microscope image detected by the focusing completion detection unit. When both completion of the sighting and completion of focusing are detected, the CPU controls a memory device to record a sample image acquired by a camera head on a record medium.

摘要翻译： 相机头通过拍摄由显微镜主体获得的样本的放大图像来获取样本图像。 存储器件将样品图像记录在记录介质中。 CPU根据构成由R.G.B数据值检测到的显微镜图像的每个像素的R.G.B数据值来检测显微镜主体中的观察部分的观察完成。 此外，CPU基于由聚焦完成检测单元检测到的显微镜图像的对比度的高度，通过显微镜边界检测对观察部分的聚焦的完成。 当检测到瞄准和完成聚焦的两者完成时，CPU控制存储装置将由相机头获取的样本图像记录在记录介质上。

公开(公告)号：US20080151367A1

公开(公告)日：2008-06-26

申请号：US12002737

申请日：2007-12-18

申请人： Shinichiro Aizaki ,  Yujin Arai

发明人： Shinichiro Aizaki ,  Yujin Arai

IPC分类号： G02B21/06

CPC分类号： G02B21/16 ,  G01N21/645 ,  G02B21/082 ,  G02B21/362

摘要： An unit for switchable arranging an arbitrary optical element on an optical path of fluorescence from among a plurality of types of the optical elements that transmit an excitation beam for exciting a sample and fluorescence emitted from the sample; an unit for picking up the observation image via the optical element arranged; and an unit for determining a type of the optical element arranged on the basis of the observation image picked up are prepared in order to provide a microscope image processing device, a program product, a program transmission medium and a method are provided, by which an optical element such as a fluorescence cube set on a fluorescence microscope can be identified on the basis of a detection result of an image pick up device that picks up an image of a sample to be observed by using the fluorescence microscope.

摘要翻译： 一种用于从透射用于激发样品的激发光束和从样品发射的荧光的多种类型的光学元件中的可选择地将任意光学元件布置在荧光的光路上的单元; 用于通过布置的光学元件拾取观察图像的单元; 准备用于确定基于拾取的观察图像布置的光学元件的类型的单元，以提供显微镜图像处理装置，程序产品，程序传送介质和方法，通过该装置， 可以基于通过使用荧光显微镜拍摄要观察的样品的图像的图像拾取装置的检测结果来识别荧光显微镜上设置的荧光立方体等光学元件。

公开(公告)号：US07220974B2

公开(公告)日：2007-05-22

申请号：US11128137

申请日：2005-05-11

申请人： Toshiyuki Hattori ,  Yujin Arai

发明人： Toshiyuki Hattori ,  Yujin Arai

IPC分类号： G02B21/00

CPC分类号： G02B21/0076 ,  G02B21/008

摘要： A fluorescence detection apparatus irradiates a sample with an excitation light having different wavelengths, spectrally detects fluorescence from the sample, and includes: a comparison unit for comparing the wavelength of the excitation light with the starting wavelength of a fluorescent spectrum detection bandwidth; and a determination unit for determining an excitation light irradiation timing such that the irradiation of the excitation wavelength is stopped when the wavelength of the excitation light is longer than the starting wavelength.

摘要翻译： 荧光检测装置用具有不同波长的激发光照射样品，从样品中光谱检测荧光，并且包括：比较单元，用于将激发光的波长与荧光光谱检测带宽的起始波长进行比较; 以及确定单元，用于确定激发光照射正时，使得当激发光的波长比起始波长长时，激发波长的照射停止。

公开(公告)号：US08040403B2

公开(公告)日：2011-10-18

申请号：US12077562

申请日：2008-03-20

申请人： Shinya Sakamoto ,  Yujin Arai

发明人： Shinya Sakamoto ,  Yujin Arai

IPC分类号： H04N9/64 ,  H04N5/235 ,  H04N5/228

CPC分类号： H04N5/361 ,  H04N5/367

摘要： An image capturing apparatus having a shutter for making an image capturing element enter a light-shielded state or a light-unshielded state comprises an image capturing condition storing unit for storing a plurality of image capturing conditions, a dark-time image data storing unit for storing a plurality of pieces of dark-time image data captured with the image capturing element under the image capturing conditions in the light-shielded state, a bright-time image data storing unit for storing bright-time image data captured with the image capturing element in the light-unshielded state, a dark-time image data extracting unit for extracting a dark-time image captured under an image capturing condition corresponding to an image capturing condition under which the bright-time image is captured, and a correcting unit for correcting the bright-time image data based on the dark-time image data extracted by the dark-time image data extracting unit.

摘要翻译： 具有用于使图像拍摄元件进入遮光状态或非遮光状态的快门的图像拍摄设备包括用于存储多个图像拍摄条件的图像拍摄条件存储单元，用于存储多个图像捕获条件的黑暗时间图像数据存储单元 将在图像拍摄条件下拍摄的多个暗时间图像数据存储在遮光状态下的亮时图像数据存储单元，用于存储与图像拍摄元件捕获的亮时间图像数据 在非遮光状态下，提供黑暗时间图像数据提取单元，用于提取在与拍摄明亮时间图像的图像拍摄条件相对应的图像拍摄条件下拍摄的暗时图像;以及校正单元， 基于由暗时图像数据提取单元提取的暗时图像数据的亮时图像数据。

公开(公告)号：US20080231725A1

公开(公告)日：2008-09-25

申请号：US12077562

申请日：2008-03-20

申请人： Shinya Sakamoto ,  Yujin Arai

发明人： Shinya Sakamoto ,  Yujin Arai

IPC分类号： H04N5/225

CPC分类号： H04N5/361 ,  H04N5/367

摘要： An image capturing apparatus having a shutter for making an image capturing element enter a light-shielded state or a light-unshielded state comprises an image capturing condition storing unit for storing a plurality of image capturing conditions, a dark-time image data storing unit for storing a plurality of pieces of dark-time image data captured with the image capturing element under the image capturing conditions in the light-shielded state, a bright-time image data storing unit for storing bright-time image data captured with the image capturing element in the light-unshielded state, a dark-time image data extracting unit for extracting a dark-time image captured under an image capturing condition corresponding to an image capturing condition under which the bright-time image is captured, and a correcting unit for correcting the bright-time image data based on the dark-time image data extracted by the dark-time image data extracting unit.

摘要翻译： 具有用于使图像拍摄元件进入遮光状态或非遮光状态的快门的图像拍摄设备包括用于存储多个图像拍摄条件的图像拍摄条件存储单元，用于存储多个图像捕获条件的黑暗时间图像数据存储单元 将在图像拍摄条件下拍摄的多个暗时间图像数据存储在遮光状态下的亮时图像数据存储单元，用于存储与图像拍摄元件捕获的亮时间图像数据 在非遮光状态下，提供黑暗时间图像数据提取单元，用于提取在与拍摄明亮时间图像的图像拍摄条件相对应的图像拍摄条件下拍摄的暗时图像;以及校正单元， 基于由暗时图像数据提取单元提取的暗时图像数据的亮时图像数据。