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公开(公告)号：US20120028835A1
公开(公告)日：2012-02-02
申请号：US13272399
申请日：2011-10-13
申请人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke
发明人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke
IPC分类号： C40B30/04 , C40B40/10 , G01N33/574
CPC分类号： G01N33/57484
摘要： Disclosed is a method aiding in the assessment of cancer. It involves the use of the secernin-1 protein (SCRN1) as a universal marker of different cancer types. More specifically disclosed is a method for assessing cancer from a liquid sample derived from an individual by measuring SCRN1 in the sample. Measurement of SCRN1 can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译： 披露了一种有助于评估癌症的方法。 它涉及使用Secernin-1蛋白（SCRN1）作为不同癌症类型的通用标记物。 更具体地公开了通过测量样品中的SCRN1来从源自个体的液体样品中评估癌症的方法。 SCRN1的测定可以例如用于癌症的早期检测或者进行手术的患者的监视。
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公开(公告)号：US20110212464A1
公开(公告)日：2011-09-01
申请号：US13099562
申请日：2011-05-03
CPC分类号： G01N33/57407 , G01N33/57423
摘要： The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the proapoptotic caspase adaptor protein (=PACAP) as a universal marker of different types of cancer. PACAP aids in the assessment of pulmonary or lung cancer (LC), particularly of non-small cell lung carcinoma (NSCLC), but also of other specific types of cancer. Such specific types of cancer are e.g. colon, bladder, cervix, ovary, endometrial, head and neck, breast, melanoma, pancreas, kidney, prostate, esophagus, stomach or bile duct cancer. Furthermore, the present invention especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring PACAP in said sample. Measurement of PACAP can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译： 本发明涉及一种协助癌症评估的方法。 它公开了促凋亡半胱天冬酶衔接蛋白（= PACAP）作为不同类型癌症的通用标记物的使用。 PACAP有助于评估肺或肺癌（LC），特别是非小细胞肺癌（NSCLC），还有其他特定类型的癌症。 这些特定类型的癌症是例如。 结肠，膀胱，子宫颈，卵巢，子宫内膜，头颈部，乳腺，黑素瘤，胰腺，肾，前列腺，食道，胃或胆管癌。 此外，本发明特别涉及通过测量所述样品中的PACAP从个体得到的从液体样品中评估癌症的方法。 PACAP的测量可以例如用于癌症的早期检测或用于进行手术的患者的监视。
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公开(公告)号：US20110097756A1
公开(公告)日：2011-04-28
申请号：US12556879
申请日：2009-09-10
申请人： Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke , Michael Thierolf
发明人： Marie-Luise Hagmann , Johann Karl , Julia Kloeckner , Markus Roessler , Michael Tacke , Michael Thierolf
IPC分类号： C12Q1/44
CPC分类号： G01N33/57423 , G01N33/57488 , G01N2333/988
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein AP endonuclease (APEX) in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample derived from an individual by measuring APEX in the sample. Measurement of APEX can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译： 本发明涉及肺癌的评估。 它公开了蛋白质AP内切核酸酶（APEX）在肺癌评估中的应用。 它还涉及一种通过测量样品中的APEX，通过使用来自个体的液体样品在体外评估肺癌的方法。 APEX的测量可以例如用于肺癌患者的早期检测或随访。
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公开(公告)号：US20120157335A1
公开(公告)日：2012-06-21
申请号：US13351801
申请日：2012-01-17
申请人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
发明人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
IPC分类号： C40B30/04 , G01N33/573 , C40B40/10 , G01N33/574 , C07K16/40
CPC分类号： G01N33/573 , G01N33/54306 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57449 , G01N33/57488 , G01N2333/922 , G01N2800/52 , G01N2800/7028 , G16H50/30 , Y02A90/26
摘要： Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal.
摘要翻译： 提供了帮助评估癌症的方法，包括使用Flap核酸内切酶-1蛋白（= FEN1）作为不同癌症类型的通用标记。 特别地，公开了从样品中得到的来自个体的液体样品中评估癌症的方法，其包括测量样品中的FEN1。 FEN1的测量可用于癌症的早期检测或用于手术切除肿瘤的患者的监测。
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公开(公告)号：US09518990B2
公开(公告)日：2016-12-13
申请号：US13272399
申请日：2011-10-13
申请人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
发明人： Norbert Wild , Marie-Luise Hagmann , Johann Karl , Julia Riedlinger , Markus Roessler , Michael Tacke
CPC分类号： G01N33/57484
摘要： Disclosed is a method aiding in the assessment of cancer. It involves the use of the secernin-1 protein (SCRN1) as a universal marker of different cancer types. More specifically disclosed is a method for assessing cancer from a liquid sample derived from an individual by measuring SCRN1 in the sample. Measurement of SCRN1 can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译： 披露了一种有助于评估癌症的方法。 它涉及使用Secernin-1蛋白（SCRN1）作为不同癌症类型的通用标记物。 更具体地公开了通过测量样品中的SCRN1来从源自个体的液体样品中评估癌症的方法。 SCRN1的测定可以例如用于癌症的早期检测或者进行手术的患者的监视。
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公开(公告)号：US10175241B2
公开(公告)日：2019-01-08
申请号：US12968784
申请日：2010-12-15
IPC分类号： G01N33/574
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein ASC in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
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公开(公告)号：US20060194266A1
公开(公告)日：2006-08-31
申请号：US11348889
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein RLA-0 (60S acidic ribosomal protein P0) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring RLA-0 in said sample. Measurement of RLA-0 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了蛋白质RLA-0（60S酸性核糖体蛋白质P0）在结直肠癌诊断中的应用。 本发明涉及通过测量所述样品中的RLA-0从个体获得的来自液体样品的结肠直肠癌的诊断方法。 RLA-0的测定可以例如用于结肠直肠癌的早期检测或诊断。
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公开(公告)号：US20060121540A1
公开(公告)日：2006-06-08
申请号：US11287575
申请日：2005-11-23
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/8107 , G01N2800/52
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein MASP in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring MASP in said sample. Measurement of MASP can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了蛋白质MASP在结直肠癌诊断中的应用。 本发明涉及一种通过测量所述样品中的MASP从个体获得的来自液体样品的结肠直肠癌的诊断方法。 MASP的测量可以例如用于结肠直肠癌的早期检测或诊断。
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公开(公告)号：US20070218510A1
公开(公告)日：2007-09-20
申请号：US11348865
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了蛋白质蛋白酶体亚单位α3（PSA3）在结肠直肠癌诊断中的应用。 本发明涉及通过测量所述样品中的PSA3从来自个体的液体样品诊断结肠直肠癌的方法。 PSA3的测定可以例如用于结肠直肠癌的早期检测或诊断。
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10.发明授权公开(公告)号：US07205118B2
公开(公告)日：2007-04-17
申请号：US11152765
申请日：2005-06-14
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/57419 , C12Q1/48
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了蛋白质烟酰胺N-甲基转移酶（NNMT）在结肠直肠癌诊断中的应用。 本发明涉及通过在所述样品中测量NNMT从个体衍生的液体样品中诊断结肠直肠癌的方法。 NNMT的测定可以例如用于结肠直肠癌的早期检测或诊断。
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