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公开(公告)号：US20240003906A1
公开(公告)日：2024-01-04
申请号：US17919270
申请日：2020-04-15
发明人： Martin Pehrsson , Morten Asser Karsdal , Diana Julie Leeming , Mette Juul Fisker , Tina Manon-Jensen , Joachim Høg Mortensen
CPC分类号： G01N33/6887 , C07K16/18 , G01N2333/78 , G01N2800/065 , C07K2317/34 , G01N2800/7052 , G01N2800/085 , G01N2470/04 , G01N2800/56 , G01N2800/52
摘要： The present invention relates to a sandwich immunoassay and kits for detecting in a biological sample cross-linked CTX-III, and its use in evaluating the efficacy of drugs targeting lysyl oxidases (LOXs). Cross-linked CTX-III can be used as a biomarker in diseases associated with fibrosis, including liver fibrosis, chronic intestinal disease, eosinophilic esophagitis and cancer.
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公开(公告)号：US20240085428A1
公开(公告)日：2024-03-14
申请号：US18268694
申请日：2021-12-20
IPC分类号： G01N33/574 , C07K16/32 , G01N33/68
CPC分类号： G01N33/57488 , C07K16/32 , G01N33/6887 , G01N2333/78
摘要： Disclosed herein are monoclonal antibodies that specifically recognise and bind to a C-terminus of a peptide that is the C-terminus neo-epitope formed on cleavage of the N-terminal pro-peptide of the α1-chain of type XI collagen at A′511↓, and immunoassay methods and kits using and containing the antibodies. The immunoassay methods may be used for detecting and/or monitoring and/or assessing the severity or prognosis of diseases, such as, but not limited to, cancer.
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公开(公告)号：US20180238903A1
公开(公告)日：2018-08-23
申请号：US15753424
申请日：2016-08-16
CPC分类号： G01N33/6887 , C07K16/18 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N2333/78
摘要： The invention provides an immunological binding partner specifically reactive with a C-terminal epitope of the α1 chain of collagen Type VIII or with an N-terminal epitope of the mature form of the α1 chain of collagen Type VIII, and a method of immunoassay for detecting or quantitating in a sample the C-terminal epitope or the N-terminal epitope of the mature α1 chain of collagen type VIII.
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公开(公告)号：US20230280350A1
公开(公告)日：2023-09-07
申请号：US18301395
申请日：2023-04-17
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57488 , C07K16/18 , C07K2317/565 , G01N2800/7028
摘要： The present invention relates to a type XVI collagen assay and its use in evaluating diseases associated with type XVI collagen, in particular colorectal cancer and ulcerative colitis, and for identifying a subgroup of patients with Crohn’s disease that have (or are likely to develop) fibrostenotic strictures.
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公开(公告)号：US20240125802A1
公开(公告)日：2024-04-18
申请号：US18277237
申请日：2022-02-17
CPC分类号： G01N33/6893 , C07K16/18 , C07K2317/34 , C07K2317/565 , G01N2333/78 , G01N2800/14 , G01N2800/7052
摘要： A method of immunoassay for detecting and/or monitoring esophageal fibrosis and/or dysphagia in a patient and/or assessing the likelihood of or the severity of esophageal fibrosis and/or dysphagia in a patient by contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of the C5 domain of the α3 chain of type VI collagen.
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公开(公告)号：US20230358752A1
公开(公告)日：2023-11-09
申请号：US18025704
申请日：2021-09-10
发明人： Federica Genovese , Nicholas Willumsen , Alexander Lynge Reese-Petersen , Shu Sun , Morten Asser Karsdal
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N2333/78
摘要： Described herein are immunoassay methods for detecting and/or monitoring a cancer in a patient by contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of type XXVIII collagen, and detecting and determining the amount of binding between the monoclonal antibody and peptides in the sample.
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公开(公告)号：US20230184787A1
公开(公告)日：2023-06-15
申请号：US17925005
申请日：2021-05-12
发明人： Joachim Høg Mortensen , Dovile Sinkeviciute , Tina Manon-Jensen , Morten Asser Karsdal , Anne-Christine Bay-Jensen , Signe Holm Nielsen , Annika Hummersgaard Hansen , Jannie Marie Bülow Sand , Diana Julie Leeming , Nicholas Willumsen , Christina Jensen
CPC分类号： G01N33/6893 , C07K16/18 , G01N2333/4727 , G01N2800/56 , G01N2800/7095 , G01N2470/10
摘要： Disclosed herein are immunoassay methods for detecting and quantifying human neutrophil elastase (HNE) generated fragments of calprotectin in a biofluid sample; and monoclonal antibodies and assay kits for use in such methods. The methods may be used for detecting, monitoring and/or determining the status or severity of a disease characterized by or exhibiting inflammation in a patient.
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公开(公告)号：US20220196676A1
公开(公告)日：2022-06-23
申请号：US17682562
申请日：2022-02-28
摘要： The invention provides an immunological binding partner specifically reactive with a C-terminal epitope of the α1 chain of collagen Type VIII or with an N-terminal epitope of the mature form of the α1 chain of collagen Type VIII, and a method of immunoassay for detecting or quantitating in a sample the C-terminal epitope or the N-terminal epitope of the mature α1 chain of collagen type VIII.
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