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公开(公告)号：US20240085428A1
公开(公告)日：2024-03-14
申请号：US18268694
申请日：2021-12-20
IPC分类号： G01N33/574 , C07K16/32 , G01N33/68
CPC分类号： G01N33/57488 , C07K16/32 , G01N33/6887 , G01N2333/78
摘要： Disclosed herein are monoclonal antibodies that specifically recognise and bind to a C-terminus of a peptide that is the C-terminus neo-epitope formed on cleavage of the N-terminal pro-peptide of the α1-chain of type XI collagen at A′511↓, and immunoassay methods and kits using and containing the antibodies. The immunoassay methods may be used for detecting and/or monitoring and/or assessing the severity or prognosis of diseases, such as, but not limited to, cancer.
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公开(公告)号：US20240210405A1
公开(公告)日：2024-06-27
申请号：US17914101
申请日：2021-03-22
IPC分类号： G01N33/574 , C07K16/18 , G01N33/68
CPC分类号： G01N33/57488 , C07K16/18 , G01N33/6887 , C07K2317/34 , G01N2333/78 , G01N2470/10
摘要： The present invention relates to monoclonal antibodies that target collagen type XIX, and to immunoassays and kits employing the antibodies. The assays of the invention can be used in the diagnosis and monitoring of cancer.
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公开(公告)号：US20230280350A1
公开(公告)日：2023-09-07
申请号：US18301395
申请日：2023-04-17
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57488 , C07K16/18 , C07K2317/565 , G01N2800/7028
摘要： The present invention relates to a type XVI collagen assay and its use in evaluating diseases associated with type XVI collagen, in particular colorectal cancer and ulcerative colitis, and for identifying a subgroup of patients with Crohn’s disease that have (or are likely to develop) fibrostenotic strictures.
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公开(公告)号：US20230358752A1
公开(公告)日：2023-11-09
申请号：US18025704
申请日：2021-09-10
发明人： Federica Genovese , Nicholas Willumsen , Alexander Lynge Reese-Petersen , Shu Sun , Morten Asser Karsdal
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N2333/78
摘要： Described herein are immunoassay methods for detecting and/or monitoring a cancer in a patient by contacting a biofluid sample from a patient with a monoclonal antibody that specifically binds to a C-terminal epitope of type XXVIII collagen, and detecting and determining the amount of binding between the monoclonal antibody and peptides in the sample.
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公开(公告)号：US20230184787A1
公开(公告)日：2023-06-15
申请号：US17925005
申请日：2021-05-12
发明人： Joachim Høg Mortensen , Dovile Sinkeviciute , Tina Manon-Jensen , Morten Asser Karsdal , Anne-Christine Bay-Jensen , Signe Holm Nielsen , Annika Hummersgaard Hansen , Jannie Marie Bülow Sand , Diana Julie Leeming , Nicholas Willumsen , Christina Jensen
CPC分类号： G01N33/6893 , C07K16/18 , G01N2333/4727 , G01N2800/56 , G01N2800/7095 , G01N2470/10
摘要： Disclosed herein are immunoassay methods for detecting and quantifying human neutrophil elastase (HNE) generated fragments of calprotectin in a biofluid sample; and monoclonal antibodies and assay kits for use in such methods. The methods may be used for detecting, monitoring and/or determining the status or severity of a disease characterized by or exhibiting inflammation in a patient.
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公开(公告)号：US20230030529A1
公开(公告)日：2023-02-02
申请号：US17782468
申请日：2020-12-03
IPC分类号： C07K16/00 , G01N33/574 , G01N33/534
摘要： An assay measuring protease mediated degradation of type IV collagen and its biomarker potential for identifying cancer patients with a T-cell permissive tumor microenvironment is described.
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7.发明申请公开(公告)号：US20190351031A1
公开(公告)日：2019-11-21
申请号：US16413559
申请日：2019-05-15
发明人： Song Wang , Darin M. Taverna , Carl Di Casoli , Nicholas Willumsen , Morten Karsdal , Thomas Mueller
IPC分类号： A61K38/47 , A61P35/00 , A61K9/127 , A61K47/60 , G01N33/574 , G01N33/68 , A61K31/337 , A61K31/7068 , A61K38/57
摘要： Provided herein are methods of selecting subjects having cancer for combination therapy that includes administering an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme. Combination therapies can include, in addition to the anti-hyaluronan agent, a tumor-targeted taxane and, optionally, a chemotherapeutic agent such as a nucleoside analog. Combinations for performing the methods are provided, as are uses of the combinations for selecting subjects for treatment. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
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公开(公告)号：US20190257837A1
公开(公告)日：2019-08-22
申请号：US16333444
申请日：2017-09-13
发明人： Nicholas Willumsen , Cecilie Liv Bager , Anne-Cecilie Bay Jensen , Antonio Quilez-Alvarez , Morten Karsdal , Diana Oersnes-Leeming , Tina Manon-Jensen
IPC分类号： G01N33/574
摘要： Provided is a method of diagnosis or of quantitation of cancer. In the method a patient biofluid sample is obtained, an immunoassay is conducted to measure fragments of Nidogen-1 that have an N- or C-terminal neo-epitope formed by cleavage of Nidogen-1 by Cathepsin-S, where the fragments are naturally present in the sample, and associating an elevation of the measure in the patient above a normal level is associated with the presence or extent of cancer.
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