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    Artificial dura mater and process for producing the same
    1.
    发明授权
    Artificial dura mater and process for producing the same 失效
    人造硬脑膜及其制造方法

    公开(公告)号：US07736393B2

    公开(公告)日：2010-06-15

    申请号：US11578971

    申请日：2005-04-18

    申请人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

    发明人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

    IPC分类号： A61F2/02 ,  A61F2/00 ,  A61B17/00 ,  A61L15/10 ,  C08G63/91 ,  C08G65/332 ,  C08G63/08 ,  C08L67/04

    CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L2430/32 ,  Y10S623/926 ,  C08L67/04

    摘要： Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/ε-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater, 2

    摘要翻译： 本发明提供一种具有至少两层体内可降解聚合物的层压结构的人造硬膜，其至少一层为基材层，所述基材层由乳酸/乙醇酸/己内酯共聚物 ，共聚物的组分摩尔比为60-85:3-15:10-30摩尔％，共聚物的平均链长满足下述表达式（1）至（3）及其制备方法， 当使用这种人造硬膜时，由于缝合孔的膨胀小而导致液体泄漏，并且其保持其强度的时间段适宜地比再生的时间长一点 自然硬度，2

    Artificial Dura Mater and Process for Producing the Same
    2.
    发明申请
    Artificial Dura Mater and Process for Producing the Same 失效
    人造硬脑膜及其制造方法

    公开(公告)号：US20070233275A1

    公开(公告)日：2007-10-04

    申请号：US11578971

    申请日：2005-04-18

    申请人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

    发明人： Noriaki Shirahama ,  Tomokazu Mukai ,  Takao Okada ,  Yukari Imamura ,  Yoshimichi Fujiyama

    IPC分类号： A61F2/02

    CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L2430/32 ,  Y10S623/926 ,  C08L67/04

    摘要： Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/ε-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater, 2

    摘要翻译： 本发明提供一种人造硬膜，其具有至少两层体内可降解聚合物的层叠结构，其至少一层为基材层，所述基材层由乳酸/乙醇酸/ε-己内酯共聚物形成， 所述共聚物的组分摩尔比为60-85:3-15:10-30摩尔％，所述共聚物的平均链长满足下述表达式（1）至（3）及其制备方法， 当使用这种人造硬脑膜时，不会引起液体渗漏，因为缝合孔的膨胀小，并且其保持其强度的时间段适宜地比自动切口再生所需的时间长一点 2， <？in-line-formula description =“In-line formula”end =“lead”？> 1 < L（GA）<[GA％/（LA％+ GA％+ CL％）] xXx0。 58（2）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> 1 < L（CL）<[CL％/（LA％+ GA％+ CL％）xXx0。 其中L（LA），L（GA）和L（CL）表示乳酸单元的平均链长，58（3）<？ 乙醇酸单元和己内酯单元，LA％，GA％和CL％表示共聚物中乳酸组分，乙醇酸组分己内酯组分的摩尔比，X是共聚物的聚合度。