公开(公告)号：US5843708A

公开(公告)日：1998-12-01

申请号：US462371

申请日：1995-06-05

申请人： Norman Hardman ,  Laura Lee Gill ,  Ronald F.J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

发明人： Norman Hardman ,  Laura Lee Gill ,  Ronald F.J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

IPC分类号： C07K16/30 ,  C07K16/46 ,  C12P21/08 ,  C12N15/00 ,  C07K16/00 ,  C12P21/04 ,  C12P21/06

CPC分类号： C07K16/3007 ,  C07K16/462 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33

摘要： The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.

公开(公告)号：US6020153A

公开(公告)日：2000-02-01

申请号：US307087

申请日：1994-09-16

申请人： Norman Hardman ,  Laura Lee Gill ,  Ronald F. J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

发明人： Norman Hardman ,  Laura Lee Gill ,  Ronald F. J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

IPC分类号： C07K16/30 ,  C07K16/46 ,  C12P21/08 ,  G01N33/574 ,  C12N15/00 ,  C07H21/04 ,  C12N5/00 ,  C12P21/06 ,  C12D21/08

CPC分类号： C07K16/3007 ,  C07K16/462 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33

摘要： The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.

摘要翻译： 本发明涉及对人癌胚抗原（CEA）具有高特异性和亲和力的鼠/人嵌合单克隆抗体，其衍生物，制备这些抗体及其衍生物的方法，编码这些抗体重链和轻链的DNA，过程 用于制备所述DNA，产生和分泌抗体的哺乳动物细胞系和用于制备所述细胞系的方法。 嵌合抗体及其衍生物在体外和体内用于临床目的，特别是用于诊断癌症，用于肿瘤的定位和体内成像，用于治疗，例如癌症。 细胞毒素的定点递送和类似目的。 本发明还涉及含有所述嵌合单克隆抗体和/或其衍生物的测试试剂盒和药物组合物。