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公开(公告)号：US20180110743A1
公开(公告)日：2018-04-26
申请号：US15559327
申请日：2016-03-18
Applicant: Northwestern University , Zhejiang University
Inventor： Sui Huang , Zhi Chen , Yanning Liu , John T. Norton , Chen Wang , Guohua Lou , Richard M. Green
IPC: A61K31/137 , A61P35/00 , A61K31/44
CPC classification number: A61K31/137 , A61K31/44 , A61P35/00 , C07D213/81 , A61K2300/00
Abstract: Provided herein are compositions and methods for treating, ameliorating, or preventing hepatocellular carcinoma in patients. In particular, the invention relates to methods of treating, ameliorating, or preventing hepatocellular carcinoma in a patient, comprising administering 6-methoxyethylamino-numonafide alone or in combination with sorafenib.
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公开(公告)号：US11150185B2
公开(公告)日：2021-10-19
申请号：US16017766
申请日：2018-06-25
Applicant: Northwestern University
Inventor： Chen He , David J. Weinberg , Emily A. Weiss , Jeremiah Yoonsung Kim , Chen Wang , Andrew Lee
Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.
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3.发明申请公开(公告)号：US20180013065A1
公开(公告)日：2018-01-11
申请号：US15696769
申请日：2017-09-06
Applicant: Northwestern University
Inventor： Alexander James Smith , Chen Wang , Jiaxing Huang , Cheng Sun
CPC classification number: H01L51/0014 , G11B7/00 , H01L31/02363 , H01L51/0036 , H01L51/0043 , H01L51/4253 , H01L51/44 , H01L51/447 , Y02E10/549
Abstract: Photonic devices are provided comprising a photoactive layer and at least one additional layer, wherein a surface of the photoactive layer or a surface of the at least one additional layer has imprinted thereon a quasi-random pattern of nanostructures corresponding to a quasi-random pattern of nanostructures defined in a recording layer of a pre-written optical media disc. Methods of patterning a layer of a photonic device are also provided.
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公开(公告)号：US11241436B2
公开(公告)日：2022-02-08
申请号：US16480885
申请日：2018-01-25
Applicant: Northwestern University , The United States of America,as represented by the Secretary,Department of Health and Human Services , University of Kansas
Inventor： Congcong He , Sui Huang , Chen Wang , Altea Rocchi , Juan Jose Marugan , Marc Ferrer , Samarjit Patnaik , Yuchi Chen , Kevin Frankowski , Frank J. Schoenen
IPC: A61K31/519 , A61P25/30 , A61K31/704
Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
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公开(公告)号：US20160109456A1
公开(公告)日：2016-04-21
申请号：US14884254
申请日：2015-10-15
Applicant: Northwestern University , Cold Spring Harbor Laboratory
Inventor： Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
IPC: G01N33/574 , A61K49/00 , C12Q1/68
CPC classification number: G01N33/57496 , A61K49/0004 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57419 , G01N2500/10 , G01N2800/56
Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。
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Patent Agency Ranking
公开(公告)号：US20180372637A1
公开(公告)日：2018-12-27
申请号：US16017766
申请日：2018-06-25
Applicant: Northwestern University
Inventor： Chen He , David J. Weinberg , Emily A. Weiss , Jeremiah Yoonsung Kim , Chen Wang , Andrew Lee
Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.
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公开(公告)号：US10134989B2
公开(公告)日：2018-11-20
申请号：US15696769
申请日：2017-09-06
Applicant: Northwestern University
Inventor： Alexander James Smith , Chen Wang , Jiaxing Huang , Cheng Sun
Abstract: Photonic devices are provided comprising a photoactive layer and at least one additional layer, wherein a surface of the photoactive layer or a surface of the at least one additional layer has imprinted thereon a quasi-random pattern of nanostructures corresponding to a quasi-random pattern of nanostructures defined in a recording layer of a pre-written optical media disc. Methods of patterning a layer of a photonic device are also provided.
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公开(公告)号：US09786845B1
公开(公告)日：2017-10-10
申请号：US14839112
申请日：2015-08-28
Applicant: Northwestern University
Inventor： Alexander James Smith , Chen Wang , Jiaxing Huang , Cheng Sun
CPC classification number: H01L51/0014 , H01L51/44 , Y02E10/549
Abstract: Methods of patterning a layer of a photonic device are provided using stamps or masks derived from pre-written optical media discs. One method comprises pressing a stamp on a surface of a layer of a photonic device, the stamp comprising a stamping surface which defines a negative replica of a quasi-random pattern of nanostructures defined in a recording layer of a pre-written optical media disc, for a period of time sufficient to imprint the quasi-random pattern of nanostructures defined in the recording layer of the pre-written optical media disc onto the surface of the layer of the photonic device; and removing the stamp. The stamps, the masks, and the photonic devices comprising the patterned layers are also provided.
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公开(公告)号：US11796472B2
公开(公告)日：2023-10-24
申请号：US17505392
申请日：2021-10-19
Applicant: Northwestern University
Inventor： Chen He , David J. Weinberg , Emily A. Weiss , Jeremiah Yoonsung Kim , Chen Wang , Andrew Lee
CPC classification number: G01N21/6428 , C01G21/21 , G01N21/6489 , H10K50/115 , B82Y15/00 , B82Y20/00 , B82Y40/00 , C01P2004/64 , G01N2021/6432
Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.
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10.发明授权公开(公告)号：US10301314B2
公开(公告)日：2019-05-28
申请号：US15606740
申请日：2017-05-26
Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Kansas , Northwestern University
Inventor： Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng , Chen Wang
IPC: A61K31/519 , A61P35/04 , C07D487/04 , C07F7/18 , A61K31/695 , A61K45/06
Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
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