公开(公告)号：US10301314B2

公开(公告)日：2019-05-28

申请号：US15606740

申请日：2017-05-26

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  University of Kansas ,  Northwestern University

发明人： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng ,  Chen Wang

IPC分类号： A61K31/519 ,  A61P35/04 ,  C07D487/04 ,  C07F7/18 ,  A61K31/695 ,  A61K45/06

摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

公开(公告)号：US09663521B2

公开(公告)日：2017-05-30

申请号：US14364759

申请日：2012-12-17

申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  UNIVERSITY OF KANSAS ,  NORTH-WESTERN UNIVERSITY

发明人： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/18 ,  A61P35/02 ,  A61P35/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/1804

摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

公开(公告)号：US20170260192A1

公开(公告)日：2017-09-14

申请号：US15606740

申请日：2017-05-26

申请人： The United States of America, as represented by the Secretary, Dept of Health and Human Services ,  University of Kansas ,  Northwestern University

发明人： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng

IPC分类号： C07D487/04 ,  C07F7/18 ,  A61K45/06 ,  A61K31/519 ,  A61K31/695

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/1804

摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

公开(公告)号：US20140378503A1

公开(公告)日：2014-12-25

申请号：US14480235

申请日：2014-09-08

申请人： NORTHWESTERN UNIVERSITY

发明人： Sui Huang ,  John Norton ,  Daniel Appella ,  Mark Witschi

IPC分类号： C07D221/14 ,  A61K31/473 ,  A61K45/06

CPC分类号： C07D221/14 ,  A61K31/43 ,  A61K31/473 ,  A61K45/06 ,  A61K2300/00 ,  C07D217/24

摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.

摘要翻译： 本发明涉及抗癌化合物，其发现方法及其治疗用途。 特别地，本发明提供了已知的抗癌化合物阿米卡德和结构和功能相关化合物的类似物，以及使用这些化合物作为治疗剂来治疗与过度增殖相关的许多病症的方法。

公开(公告)号：US09878984B2

公开(公告)日：2018-01-30

申请号：US14480235

申请日：2014-09-08

申请人： NORTHWESTERN UNIVERSITY

发明人： Sui Huang ,  John Norton ,  Daniel Appella ,  Mark Witschi

IPC分类号： A61K31/473 ,  C07D221/14 ,  A61K31/43 ,  C07D217/24 ,  A61K45/06

CPC分类号： C07D221/14 ,  A61K31/43 ,  A61K31/473 ,  A61K45/06 ,  A61K2300/00 ,  C07D217/24

摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.

公开(公告)号：US08829025B2

公开(公告)日：2014-09-09

申请号：US13853513

申请日：2013-03-29

申请人： Northwestern University

发明人： Sui Huang ,  John Norton ,  Daniel Appella ,  Mark Witschi

IPC分类号： A61K31/473 ,  A61K45/06 ,  C07D217/24 ,  A61K31/43

CPC分类号： C07D221/14 ,  A61K31/43 ,  A61K31/473 ,  A61K45/06 ,  A61K2300/00 ,  C07D217/24

摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.

摘要翻译： 本发明涉及抗癌化合物，其发现方法及其治疗用途。 特别地，本发明提供了已知的抗癌化合物阿米卡德和结构和功能相关化合物的类似物，以及使用这些化合物作为治疗剂来治疗与过度增殖相关的许多病症的方法。

公开(公告)号：US20130225634A1

公开(公告)日：2013-08-29

申请号：US13853513

申请日：2013-03-29

申请人： NORTHWESTERN UNIVERSITY

发明人： Sui Huang ,  John Norton ,  Daniel Appella ,  Mark Witschi

IPC分类号： A61K31/473 ,  A61K45/06

CPC分类号： C07D221/14 ,  A61K31/43 ,  A61K31/473 ,  A61K45/06 ,  A61K2300/00 ,  C07D217/24

摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.

摘要翻译： 本发明涉及抗癌化合物，其发现方法及其治疗用途。 特别地，本发明提供了已知的抗癌化合物阿米卡德和结构和功能相关化合物的类似物，以及使用这些化合物作为治疗剂来治疗与过度增殖相关的许多病症的方法。