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1.发明授权公开(公告)号：US10301314B2
公开(公告)日：2019-05-28
申请号：US15606740
申请日：2017-05-26
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Kansas , Northwestern University
发明人： Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng , Chen Wang
IPC分类号： A61K31/519 , A61P35/04 , C07D487/04 , C07F7/18 , A61K31/695 , A61K45/06
摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
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公开(公告)号：US11241436B2
公开(公告)日：2022-02-08
申请号：US16480885
申请日：2018-01-25
申请人： Northwestern University , The United States of America,as represented by the Secretary,Department of Health and Human Services , University of Kansas
发明人： Congcong He , Sui Huang , Chen Wang , Altea Rocchi , Juan Jose Marugan , Marc Ferrer , Samarjit Patnaik , Yuchi Chen , Kevin Frankowski , Frank J. Schoenen
IPC分类号： A61K31/519 , A61P25/30 , A61K31/704
摘要： The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
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公开(公告)号：US10202367B2
公开(公告)日：2019-02-12
申请号：US15317864
申请日：2015-06-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Kansas
发明人： Tsanyang Liang , Zongyi Hu , Juan Jose Marugan , Noel Terrence Southall , Shanshan He , Xin Hu , Jingbo Xiao , Marc Ferrer , Wei Zheng , Kevin J. Frankowski , Frank J. Schoenen , Kelin Li
IPC分类号： C07D413/14 , A61K31/4545 , C07D417/14 , C07D471/08 , A61K31/496 , A61K31/5377 , C07D413/06 , A61K31/4178 , A61K31/454 , A61K31/7056 , A61K31/7068 , A61K38/07 , A61K38/13 , A61K38/21
摘要： Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.
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4.发明授权公开(公告)号：US09663521B2
公开(公告)日：2017-05-30
申请号：US14364759
申请日：2012-12-17
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITY OF KANSAS , NORTH-WESTERN UNIVERSITY
发明人： Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng
IPC分类号： C07D487/04 , A61K31/519 , A61K31/695 , A61K45/06 , C07F7/18 , A61P35/02 , A61P35/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/695 , A61K45/06 , C07F7/1804
摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
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5.发明申请公开(公告)号：US20170260192A1
公开(公告)日：2017-09-14
申请号：US15606740
申请日：2017-05-26
申请人： The United States of America, as represented by the Secretary, Dept of Health and Human Services , University of Kansas , Northwestern University
发明人： Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng
IPC分类号： C07D487/04 , C07F7/18 , A61K45/06 , A61K31/519 , A61K31/695
CPC分类号： C07D487/04 , A61K31/519 , A61K31/695 , A61K45/06 , C07F7/1804
摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
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公开(公告)号：US10124377B2
公开(公告)日：2018-11-13
申请号：US15289540
申请日：2016-10-10
申请人： UNIVERSITY OF KANSAS
摘要： A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a primary fluid loop containing chilled fluid and a secondary fluid loop containing a cooling fluid which is in thermal communication the laboratory device. The primary fluid loop is located behind the fume hood wall and not in the interior work area.
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公开(公告)号：USD821554S1
公开(公告)日：2018-06-26
申请号：US29579468
申请日：2016-09-30
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公开(公告)号：US20170114053A1
公开(公告)日：2017-04-27
申请号：US15317864
申请日：2015-06-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , University of Kansas
发明人： Tsanyang Liang , Zongyi Hu , Juan Jose Marugan , Noel Terrence Southall , Shanshan He , Xin Hu , Jingbo Xiao , Marc Ferrer , Wei Zheng , Kevin J. Frankowski , Frank J. Schoenen , Kelin Li
IPC分类号： C07D413/06 , A61K31/7056 , A61K31/4545 , A61K31/454 , A61K31/5377 , A61K31/7068 , C07D417/14 , A61K38/21 , A61K38/07 , A61K31/4178 , A61K38/13 , C07D413/14 , A61K31/496
CPC分类号： C07D413/06 , A61K31/4178 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K31/7068 , A61K38/07 , A61K38/13 , A61K38/212 , C07D413/14 , C07D417/14 , C07D471/08 , Y02A50/385
摘要： Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.
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