公开(公告)号：US20180088048A1

公开(公告)日：2018-03-29

申请号：US15584018

申请日：2017-05-01

Applicant: Northwestern University

Inventor： Biqin Dong ,  Janel L. Davis ,  Cheng Sun ,  Hao F. Zhang ,  Kieren J. Patel ,  Ben Urban ,  Vadim Backman ,  Luay Almassalha ,  Yolanda Stypula-Cyrus ,  The-Quyen Nguyen

IPC: G01N21/64 ,  C12Q1/6825 ,  G01N33/53

CPC classification number: G01N21/6428 ,  C12Q1/6825 ,  C12Q1/6841 ,  G01N21/6458 ,  G01N33/5302 ,  G01N2021/6441

Abstract: The devices, methods, and systems of the present disclosure provide for spectroscopic super-resolution microscopic imaging. In some examples, spectroscopic super-resolution microscopic imaging may be referred to or comprise spectroscopic photon localization microscopy (SPLM), a method which may employ the use of extrinsic labels or tags in a test sample suitable for imaging. In some examples spectroscopic super-resolution microscopic or spectroscopic photon localization microscopy (SPLM) may not employ extrinsic labels and be performed using the intrinsic contrast of the test sample or test sample material.Generally, spectroscopic super-resolution microscopic imaging may comprise resolving one or more non-diffraction limited images of an area of a test sample by acquiring both localization information of a subset of molecules using microscopic methods known in the art, and simultaneously or substantially simultaneously, acquiring spectral data about the same or corresponding molecules in the subset. This method maybe useful to detect a variety of features in cellular material for the molecular characterization of cells and disease.

公开(公告)号：US20200217837A1

公开(公告)日：2020-07-09

申请号：US16318037

申请日：2017-07-14

Applicant: Northwestern University

Inventor： Vadim Backman ,  Igal Szleifer ,  Luay Almassalha ,  John Chandler ,  Greta Bauer ,  Scott Gladstein

IPC: G01N33/50 ,  G01N33/68 ,  G01N33/574

Abstract: Provided herein are chromatin protection therapeutics (CPTs) and methods of targeting chromatin heterogeneity for the treatment of cancer therewith. In particular compositions and methods are provided that target physical variations in chromatin topology, reduce chromatic heterogeneity, and treat cancer or inhibit the development of resistance to other cancer therapeutics.