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1.发明申请公开(公告)号：US20210063644A1
公开(公告)日：2021-03-04
申请号：US16883930
申请日：2020-05-26
Applicant: Northwestern University , American BioOptics, LLC
Inventor： Vadim Backman , Jeremy D. Rogers , Nikhil N. Mutyal , Bradley Gould , Andrew J. Radosevich , The Quyen Nguyen
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
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公开(公告)号：US10241041B2
公开(公告)日：2019-03-26
申请号：US15590745
申请日：2017-05-09
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Ji Yi
Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio or scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.
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3.发明申请公开(公告)号：US20150348287A1
公开(公告)日：2015-12-03
申请号：US14698641
申请日：2015-04-28
Applicant: Northwestern University
Inventor： Ji Yi , Wenzhong Liu , Vadim Backman , Hao F. Zhang
CPC classification number: A61B3/102 , A61B1/04 , A61B3/1233 , A61B5/0066 , A61B5/0073 , A61B5/0205 , A61B5/0261 , A61B5/14507 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14542 , A61B5/14551 , G01B9/02091 , G06F17/10 , G06F17/13 , G06T7/0012 , G06T7/0014 , G06T11/003 , G06T2207/10028 , G06T2207/10101
Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
Abstract translation: 本公开提供了使用非侵入性非接触成像技术（例如OCT）来确定靶中一种或多种分析物浓度的变化速率的系统和方法。 通常，获取OCT数据，并从OCT扫描中提取光学信息，以定量地确定靶中的流体流速和一种或多种分析物的浓度。 两种计算都可以提供一种方法来确定分析物随时间变化的速度。 本公开的示例性方法和系统可用于评估组织的代谢，其中氧是所检测的分析物或其它功能状态，并且通常用于诊断，监测和治疗疾病。
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4.发明授权公开(公告)号：US11560414B2
公开(公告)日：2023-01-24
申请号：US16877275
申请日：2020-05-18
Applicant: Northwestern University
Inventor： Hemant K. Roy , Vadim Backman
IPC: A61K38/18 , A61K38/00 , A61P35/00 , A61P3/10 , A61P9/00 , C07K14/47 , C07K14/52 , C07K14/475 , A61K31/282
Abstract: Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.
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公开(公告)号：US20200217837A1
公开(公告)日：2020-07-09
申请号：US16318037
申请日：2017-07-14
Applicant: Northwestern University
Inventor： Vadim Backman , Igal Szleifer , Luay Almassalha , John Chandler , Greta Bauer , Scott Gladstein
IPC: G01N33/50 , G01N33/68 , G01N33/574
Abstract: Provided herein are chromatin protection therapeutics (CPTs) and methods of targeting chromatin heterogeneity for the treatment of cancer therewith. In particular compositions and methods are provided that target physical variations in chromatin topology, reduce chromatic heterogeneity, and treat cancer or inhibit the development of resistance to other cancer therapeutics.
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Patent Agency Ranking
公开(公告)号：US20180127833A1
公开(公告)日：2018-05-10
申请号：US15727924
申请日：2017-10-09
Inventor： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
IPC: C12Q1/6886 , G01N21/64 , G01N33/574 , G01N21/41 , C12Q1/6806
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N21/41 , G01N21/64 , G01N21/6486 , G01N33/57407 , G01N33/57411 , G01N33/57419 , G01N33/57484
Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.
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7.发明授权公开(公告)号：US09314164B2
公开(公告)日：2016-04-19
申请号：US13839234
申请日：2013-03-15
Inventor： Vadim Backman , Hemant Roy , Young L. Kim , Michael Siegel , Vladimir Turzhitsky
IPC: A61B5/00 , A61B5/0205 , A61B5/026 , A61B5/145 , A61B5/1455 , A61B5/1459
CPC classification number: A61B5/0205 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/0261 , A61B5/14535 , A61B5/14546 , A61B5/14551 , A61B5/1459 , A61B5/4255 , A61B2562/0233
Abstract: The present invention, in one aspect, relates to a method for distinguishing between possible adenomatous and hyperplastic polyps using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue.
Abstract translation: 本发明的一方面涉及使用所谓的“微血管供血的早期增加”（EIBS）区分可能的腺瘤性和增生性息肉的方法，该方法存在于接近但不是本身的组织中 ，异常组织。
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公开(公告)号：US10584389B2
公开(公告)日：2020-03-10
申请号：US15727924
申请日：2017-10-09
Inventor： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
IPC: C12Q1/68 , C12Q1/6886 , G01N21/41 , G01N33/574 , C12Q1/6806 , G01N21/64 , G01N1/28
Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.
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公开(公告)号：US10229310B2
公开(公告)日：2019-03-12
申请号：US15794101
申请日：2017-10-26
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Hariharan Subramanian , John E. Chandler , Craig White , Jeremy D. Rogers , Lusik Cherkezyan
IPC: G06K9/00 , G02B21/36 , G02B21/06 , G02B21/16 , H04N21/232 , H04N21/235 , G01J3/44 , G01J3/12 , G01J3/28 , G01N21/47 , H04N5/235 , H04N5/232
Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
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公开(公告)号：US20180256025A1
公开(公告)日：2018-09-13
申请号：US15972753
申请日：2018-05-07
Applicant: Northwestern University
Inventor： Ji Yi , Wenzhong Liu , Vadim Backman , Hao F. Zhang , Kieren J. Patel
IPC: A61B3/10 , G06T7/00 , A61B5/1455 , A61B3/12 , A61B5/145 , A61B5/0205 , A61B1/04 , G06F17/13
CPC classification number: A61B3/102 , A61B1/04 , A61B3/1233 , A61B5/0066 , A61B5/0073 , A61B5/0205 , A61B5/0261 , A61B5/14507 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14542 , A61B5/14551 , G01B9/02091 , G06F17/10 , G06F17/13 , G06T7/0012 , G06T7/0014 , G06T11/003 , G06T2207/10028 , G06T2207/10101
Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
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