公开(公告)号：US20180303941A1

公开(公告)日：2018-10-25

申请号：US15529288

申请日：2015-11-25

Applicant: Northwestern University

Inventor： Guillermo A. AMEER ,  Michele JEN

IPC: A61K47/32 ,  A61K38/50 ,  A61P17/02 ,  A61K9/00 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L15/62 ,  A61K48/00

CPC classification number: A61K47/32 ,  A61K9/0014 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61K48/0016 ,  A61K48/005 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2430/34 ,  A61P17/02 ,  C12N2800/95 ,  C12Y305/01

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.