公开(公告)号：US20210115065A1

公开(公告)日：2021-04-22

申请号：US17076126

申请日：2020-10-21

Applicant: Novartis AG

Inventor： Nicole Alice Blaquiere ,  Richard Yichong Huang ,  Thomas Martin Kirrane, JR. ,  Andreas Kordikowski ,  Anne-Catherine Mata ,  Christopher Ronald Sarko ,  Benjamin Robert Taft ,  Grace Lamprecht Waldron ,  Fumiaki Yokokawa ,  Tingying Zhu

IPC: C07D513/04 ,  C07D519/00 ,  A61K31/4545 ,  A61K31/433 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/5386 ,  A61K31/438 ,  A61K31/5355 ,  A61K31/499 ,  A61K45/06

Abstract: The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

公开(公告)号：US11597733B2

公开(公告)日：2023-03-07

申请号：US17076126

申请日：2020-10-21

Applicant: Novartis AG

Inventor： Nicole Alice Blaquiere ,  Richard Yichong Huang ,  Thomas Martin Kirrane, Jr. ,  Andreas Kordikowski ,  Anne-Catherine Mata ,  Christopher Ronald Sarko ,  Benjamin Robert Taft ,  Grace Lamprecht Waldron ,  Fumiaki Yokokawa ,  Tingying Zhu

IPC: C07D513/04 ,  C07D519/00 ,  A61K31/4545 ,  A61K31/433 ,  A61K31/496 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/5386 ,  A61K31/438 ,  A61K31/5355 ,  A61K31/499 ,  A61K31/454

Abstract: The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

公开(公告)号：US11135239B1

公开(公告)日：2021-10-05

申请号：US17199736

申请日：2021-03-12

Applicant: Novartis AG

Inventor： Christoph Bucher ,  Dietmar Flubacher ,  Jeremiah Douglas Foutch ,  Malay Ghosh ,  Johannes Franz Kluge ,  Zaixing Li ,  Cale Ry McAlister ,  Liladhar Murlidhar Waykole ,  Jens Sören Worthmann ,  Tingying Zhu

IPC: A61K31/724 ,  A61K31/381 ,  C07D339/04 ,  A61K47/38 ,  A61K47/02 ,  C07C309/72

Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.

公开(公告)号：US11590158B2

公开(公告)日：2023-02-28

申请号：US17463391

申请日：2021-08-31

Applicant: Novartis AG

Inventor： Christoph Bucher ,  Dietmar Flubacher ,  Jeremiah Douglas Foutch ,  Malay Ghosh ,  Johannes Franz Kluge ,  Zaixing Li ,  Cale Ry McAlister ,  Liladhar Murlidhar Waykole ,  Jens Sören Worthmann ,  Tingying Zhu

IPC: A61K31/724 ,  C07C309/72 ,  A61K31/381 ,  A61K47/02 ,  A61K47/38 ,  C07D339/04

Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.

公开(公告)号：US20210393671A1

公开(公告)日：2021-12-23

申请号：US17463391

申请日：2021-08-31

Applicant: Novartis AG

Inventor： Christoph Bucher ,  Dietmar Flubacher ,  Jeremiah Douglas Foutch ,  Malay Ghosh ,  Johannes Franz Kluge ,  Zaixing Li ,  Cale Ry McAlister ,  Liladhar Murlidhar Waykole ,  Jens Sören Worthmann ,  Tingying Zhu

IPC: A61K31/724 ,  A61K47/02 ,  A61K47/38 ,  C07D339/04 ,  A61K31/381 ,  C07C309/72

Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.

公开(公告)号：US20210283171A1

公开(公告)日：2021-09-16

申请号：US17199736

申请日：2021-03-12

Applicant: Novartis AG

Inventor： Christoph Bucher ,  Dietmar Flubacher ,  Jeremiah Douglas Foutch ,  Malay Ghosh ,  Johannes Franz Kluge ,  Zaixing Li ,  Cale Ry McAlister ,  Liladhar Murlidhar Waykole ,  Jens Sören Worthmann ,  Tingying Zhu

IPC: A61K31/724 ,  A61K31/381 ,  C07D339/04 ,  C07C309/72 ,  A61K47/38 ,  A61K47/02

Abstract: The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.

公开(公告)号：US10947218B2

公开(公告)日：2021-03-16

申请号：US16884666

申请日：2020-05-27

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sreehari Babu ,  Jianwei Bian ,  Kai Cui ,  Michael Patrick Dillon ,  Rene Lattmann ,  Jialiang Li ,  Lv Liao ,  Dimitrios Lizos ,  Rita Ramos ,  Nikolaus Johannes Stiefl ,  Thomas Ullrich ,  Peggy Usselmann ,  Xiaoyang Wang ,  Liladhar Murlidhar Waykole ,  Sven Weiler ,  Yubo Zhang ,  Yizong Zhou ,  Tingying Zhu

IPC: A61K31/4427 ,  C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US10710980B2

公开(公告)日：2020-07-14

申请号：US16318250

申请日：2017-07-18

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Sreehari Babu ,  Jianwei Bian ,  Kai Cui ,  Michael Patrick Dillon ,  Rene Lattmann ,  Jialiang Li ,  Lv Liao ,  Dimitrios Lizos ,  Rita Ramos ,  Nikolaus Johannes Stiefl ,  Thomas Ullrich ,  Peggy Usselmann ,  Xiaoyang Wang ,  Liladhar Murlidhar Waykole ,  Sven Weiler ,  Yubo Zhang ,  Yizong Zhou ,  Tingying Zhu

IPC: C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.