公开(公告)号：US20180369386A1

公开(公告)日：2018-12-27

申请号：US16115883

申请日：2018-08-29

Applicant: Novartis AG

Inventor： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-Munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura West ,  Thomas Zabawa ,  Junping Zhao

IPC: A61K47/18 ,  C07C229/14 ,  A61K9/127 ,  A61K9/51 ,  C12N15/113 ,  C07D317/28 ,  C07D295/096 ,  C07D213/79 ,  C07D213/69 ,  C07D205/04 ,  C07C235/42 ,  A61K9/00 ,  C07C229/12 ,  C07C219/06 ,  C07C217/58 ,  A61K47/22 ,  A61K38/22 ,  A61K31/713 ,  A61K48/00

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US10792361B2

公开(公告)日：2020-10-06

申请号：US16115883

申请日：2018-08-29

Applicant: Novartis AG

Inventor： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-Munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura West ,  Thomas Zabawa ,  Junping Zhao

IPC: A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07C217/58 ,  C07C219/06 ,  C07C229/12 ,  C07D317/28 ,  C07D295/096 ,  A61K9/00 ,  A61K38/22 ,  A61K47/22 ,  C07C229/14 ,  C07C235/42 ,  C07D205/04 ,  C07D213/69 ,  C07D213/79 ,  C12N15/113 ,  A61K48/00

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US10729775B2

公开(公告)日：2020-08-04

申请号：US16021193

申请日：2018-06-28

Applicant: Novartis AG

Inventor： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura Ellen West ,  Thomas Zabawa ,  Junping Zhao

IPC: A61K47/18 ,  C12N15/113 ,  A61K47/22 ,  C07D213/79 ,  C07D317/24 ,  C07D317/28 ,  C07D205/04 ,  C07D295/096 ,  C07D213/69 ,  A61K9/127 ,  C07C217/58 ,  C07C217/60 ,  C07C217/62 ,  C07C219/22 ,  C07C219/28 ,  C07C229/12 ,  C07C235/46 ,  C07C237/08

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US10124065B2

公开(公告)日：2018-11-13

申请号：US14779939

申请日：2014-03-06

Applicant: Novartis AG

Inventor： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-Munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura West ,  Thomas Zabawa ,  Junping Zhao

IPC: C07C211/00 ,  A61K9/00 ,  C07C217/00 ,  A61K47/22 ,  A61K47/18 ,  C07C217/58 ,  C07C219/06 ,  C07C229/12 ,  C07D317/28 ,  C07D295/096 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  A61K38/22 ,  C07C229/14 ,  C07C235/42 ,  C07D205/04 ,  C07D213/69 ,  C07D213/79 ,  C12N15/113 ,  A61K48/00

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US20180296677A1

公开(公告)日：2018-10-18

申请号：US16021193

申请日：2018-06-28

Applicant: Novartis AG

Inventor： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura Ellen West ,  Thomas Zabawa ,  Junping Zhao

IPC: A61K47/18 ,  C07C235/46 ,  A61K9/127 ,  C12N15/113 ,  C07D317/28 ,  C07D317/24 ,  C07D295/096 ,  C07D213/79 ,  C07D213/69 ,  C07D205/04 ,  C07C237/08 ,  C07C229/12 ,  C07C219/28 ,  C07C219/22 ,  C07C217/62 ,  C07C217/60 ,  C07C217/58 ,  A61K47/22

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.