公开(公告)号：US12172984B2

公开(公告)日：2024-12-24

申请号：US18460428

申请日：2023-09-01

Applicant: Novartis AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Janetta Dewhurst ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R. Manning ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Yf Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US11787785B2

公开(公告)日：2023-10-17

申请号：US17693759

申请日：2022-03-14

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Janetta Dewhurst ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R. Manning ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Y F Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US10195196B2

公开(公告)日：2019-02-05

申请号：US15364248

申请日：2016-11-29

Applicant: NOVARTIS AG

Inventor： Atwood Kim Cheung ,  Donovan Noel Chin ,  Natalie Dales ,  Aleem Fazal ,  Timothy Hurley ,  John Kerrigan ,  Gary O'Brien ,  Lei Shu ,  Robert Sun ,  Moo Je Sung

IPC: A61K31/501 ,  C07D401/14 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20230019617A1

公开(公告)日：2023-01-19

申请号：US17829933

申请日：2022-06-01

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Janetta Dewhurst ,  John Ryan Kerrigan ,  Gary O'Brien ,  MooJe Sung ,  Noel Marie-France Thomsen ,  Pamela Ting

IPC: C07D401/14 ,  A61K31/4545 ,  A61K45/06 ,  C07D405/14 ,  A61K31/55

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US09545404B2

公开(公告)日：2017-01-17

申请号：US14242282

申请日：2014-04-01

Applicant: NOVARTIS AG

Inventor： Atwood Kim Cheung ,  Donovan Noel Chin ,  Natalie Dales ,  Aleem Fazal ,  Timothy Hurley ,  John Kerrigan ,  Gary O'Brien ,  Lei Shu ,  Robert Sun ,  Moo Je Sung

IPC: C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  A61K31/551 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K45/06 ,  C07D237/20 ,  C07D401/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/10

CPC classification number: A61K31/501 ,  A61K31/41 ,  A61K31/427 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/06 ,  C07D237/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US10758533B2

公开(公告)日：2020-09-01

申请号：US16237907

申请日：2019-01-02

Applicant: Novartis AG

Inventor： Atwood Kim Cheung ,  Donovan Noel Chin ,  Natalie Dales ,  Aleem Fazal ,  Timothy Brian Hurley ,  John Kerrigan ,  Gary O'Brien ,  Lei Shu ,  Robert Sun ,  Moo Je Sung

IPC: C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D403/10 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US12103919B2

公开(公告)日：2024-10-01

申请号：US17829933

申请日：2022-06-01

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Janetta Dewhurst ,  John Ryan Kerrigan ,  Gary O'Brien ,  MooJe Sung ,  Noel Marie-France Thomsen ,  Pamela Ting

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14

CPC classification number: C07D401/14 ,  A61K31/4545 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US11566022B2

公开(公告)日：2023-01-31

申请号：US17124127

申请日：2020-12-16

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Dales ,  John Ryan Kerrigan ,  Philip Lam ,  Hasnain Ahmed Malik ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Ting

IPC: C07D413/14 ,  C07D401/14 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders, including hemoglobinopathies, sickle cell disease and beta-thalassemia.

公开(公告)号：US11229648B2

公开(公告)日：2022-01-25

申请号：US16934787

申请日：2020-07-21

Applicant: Novartis AG

Inventor： Atwood Kim Cheung ,  Donovan Noel Chin ,  Natalie Dales ,  Aleem Fazal ,  Timothy Brian Hurley ,  John Kerrigan ,  Gary O'Brien ,  Lei Shu ,  Robert Sun ,  Moo Je Sung

IPC: C07D401/04 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  A61K31/501 ,  A61P21/00 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D237/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  A61K31/41 ,  A61K31/427 ,  C07D237/06

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.