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1.发明授权1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions 有权其中的1,4-二取代哒嗪类似物和用于治疗SMN缺陷相关病症的方法公开(公告)号：US09545404B2
公开(公告)日：2017-01-17
申请号：US14242282
申请日：2014-04-01
Applicant: NOVARTIS AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/501 , A61K31/502 , A61K31/506 , A61K45/06 , C07D237/20 , C07D401/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/08 , C07D487/10
CPC classification number: A61K31/501 , A61K31/41 , A61K31/427 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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Patent Agency Ranking
公开(公告)号：US10195196B2
公开(公告)日：2019-02-05
申请号：US15364248
申请日：2016-11-29
Applicant: NOVARTIS AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: A61K31/501 , C07D401/14 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US11229648B2
公开(公告)日：2022-01-25
申请号：US16934787
申请日：2020-07-21
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/04 , C07D471/10 , C07D487/08 , C07D487/10 , A61K31/501 , A61P21/00 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US11053218B2
公开(公告)日：2021-07-06
申请号：US16835938
申请日：2020-03-31
Applicant: Novartis AG
Inventor： Rohan Eric John Beckwith , Simone Bonazzi , Artiom Cernijenko , Aleem Fazal , Ritesh Bhanudasji Tichkule , Michael Scott Visser
IPC: C07D401/14 , A61K31/4412 , C07D401/04 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04 , A61P35/00
Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.
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公开(公告)号：US10414755B2
公开(公告)日：2019-09-17
申请号：US16108713
申请日：2018-08-22
Applicant: Novartis AG
Inventor： Rohan Eric John Beckwith , Simone Bonazzi , Artiom Cernijenko , Aleem Fazal , Ritesh Bhanudasji Tichkule , Michael Scott Visser
IPC: C07D401/14 , A61K31/4412 , A61P35/00 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04
Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.
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公开(公告)号：US10758533B2
公开(公告)日：2020-09-01
申请号：US16237907
申请日：2019-01-02
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D403/10 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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