公开(公告)号：US20180194823A1

公开(公告)日：2018-07-12

申请号：US15835290

申请日：2017-12-07

Applicant: Novartis AG

Inventor： Kristen JOHNSON ,  Jian SHI

IPC: C07K14/515 ,  A61K35/32 ,  G01N33/68 ,  A61K38/17 ,  A61K38/18 ,  A61K38/38 ,  C12Q1/6883 ,  A61K45/06 ,  A61K31/728 ,  C07K14/47 ,  C12N5/077 ,  A61K38/45 ,  A61K38/00

CPC classification number: C07K14/515 ,  A61K31/728 ,  A61K35/32 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/1891 ,  A61K38/385 ,  A61K38/45 ,  A61K45/06 ,  C07K14/47 ,  C07K2319/30 ,  C12N5/0655 ,  C12N2501/17 ,  C12N2506/1346 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/105 ,  G01N2800/52 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.

公开(公告)号：US20210155713A1

公开(公告)日：2021-05-27

申请号：US17058870

申请日：2019-05-29

Applicant: Novartis AG

Inventor： Michael DIDONATO ,  Christoph ERKEL ,  Anna Galkin ,  Scott GLASER ,  Klaus Felix HARTLEPP ,  Yong JIA ,  Alexandra KRAUS ,  Christian Cho-Hua LEE ,  Sarah Michelle RUE ,  Jian SHI ,  Xenia Karola WEZLER

IPC: C07K16/40 ,  A61P35/00 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: Provided herein are antibodies or antigen-binding fragments thereof, e.g., monoclonal antibodies or antigen binding fragments thereof, that specifically bind to ENTPD2 (e.g., human ENTPD2 protein), and methods of using these antibodies or antigen-binding fragments. The present invention also relates to combination therapies comprising an anti-human ENTPD2 antibody or antigen binding fragment and at least one additional therapeutic agent, and methods of using these combination therapies.

公开(公告)号：US20170327552A1

公开(公告)日：2017-11-16

申请号：US15660914

申请日：2017-07-26

Applicant: Novartis AG

Inventor： Kristen JOHNSON ,  Jian SHI

IPC: C07K14/515 ,  A61K35/32 ,  A61K38/17 ,  A61K38/18 ,  A61K38/38 ,  A61K45/06 ,  C07K14/47 ,  A61K31/728 ,  G01N33/68 ,  C12Q1/68 ,  C12N5/077 ,  A61K38/45 ,  A61K38/00

CPC classification number: C07K14/515 ,  A61K31/728 ,  A61K35/32 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/1891 ,  A61K38/385 ,  A61K38/45 ,  A61K45/06 ,  C07K14/47 ,  C07K2319/30 ,  C12N5/0655 ,  C12N2501/17 ,  C12N2506/1346 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/105 ,  G01N2800/52 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.

公开(公告)号：US20170252407A1

公开(公告)日：2017-09-07

申请号：US15457656

申请日：2017-03-13

Applicant: NOVARTIS AG

Inventor： Kristen JOHNSON ,  Jian SHI

IPC: A61K47/48 ,  A61K31/198 ,  A61K31/593 ,  A61K31/728 ,  A61K38/01 ,  A61K38/22 ,  A61K45/06 ,  A61K35/32 ,  C07K14/515 ,  C12N5/077 ,  A61K31/192 ,  A61K38/18

CPC classification number: A61K38/1891 ,  A61K31/192 ,  A61K31/198 ,  A61K31/593 ,  A61K31/728 ,  A61K35/32 ,  A61K38/014 ,  A61K38/1825 ,  A61K38/1875 ,  A61K38/225 ,  A61K45/06 ,  C07K14/515 ,  C12N5/0655 ,  C12N2501/17 ,  C12N2506/1346 ,  A61K2300/00

Abstract: The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.

公开(公告)号：US20240336701A1

公开(公告)日：2024-10-10

申请号：US18427264

申请日：2024-01-30

Applicant: Novartis AG

Inventor： Michael DIDONATO ,  Christoph ERKEL ,  Anna Galkin ,  Scott Martin GLASER ,  Klaus Felix HARTLEPP ,  Yong JIA ,  Alexandra KRAUS ,  Christian Cho-Hua LEE ,  Sarah Michelle RUE ,  Jian SHI ,  Xenia Karola WEZLER

IPC: C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/92

Abstract: Provided herein are antibodies or antigen-binding fragments thereof, e.g., monoclonal antibodies or antigen binding fragments thereof, that specifically bind to ENTPD2 (e.g., human ENTPD2 protein), and methods of using these antibodies or antigen-binding fragments. The present invention also relates to combination therapies comprising an anti-human ENTPD2 antibody or antigen binding fragment and at least one additional therapeutic agent, and methods of using these combination therapies.

公开(公告)号：US20190161527A1

公开(公告)日：2019-05-30

申请号：US16270371

申请日：2019-02-07

Applicant: Novartis AG

Inventor： Kristen JOHNSON ,  Jian SHI

IPC: C07K14/515 ,  A61K45/06 ,  A61K31/728 ,  A61K38/17 ,  A61K38/38 ,  A61K38/45 ,  A61K35/32 ,  C12Q1/6883 ,  A61K38/18 ,  G01N33/68 ,  C12N5/077 ,  C07K14/47

Abstract: The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.