专利检索 ap:("Novartis AG") AND inv:"William Roush" 第 1 页

1.

发明授权
Compounds and compositions for treating conditions associated with NLRP activity 有权

公开(公告)号：US11370763B2

公开(公告)日：2022-06-28

申请号：US16632850

申请日：2018-07-23

申请人： Novartis AG

发明人： Luigi Franchi , Shomir Ghosh , Gary Glick , Jason Katz , Anthony William Opipari, Jr. , William Roush , Hans Martin Seidel , Dong-Ming Shen , Shankar Venkatraman , David Guenther Winkler

IPC分类号： C07D265/30 , A61P1/00 , A61P11/00 , A61P19/08 , A61P35/00 , C07C381/10 , C07D209/26 , C07D211/78 , C07D215/06 , C07D231/12 , C07D239/26 , C07D239/36 , C07D261/08 , C07D263/46 , C07D277/36 , C07D317/50 , C07D333/34 , C07D401/12 , C07D409/12 , C07D417/12 , A61K45/06

摘要： In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured. The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging.

2.

发明授权
Compounds and compositions for treating conditions associated with NLRP activity 有权

公开(公告)号：US12084424B2

公开(公告)日：2024-09-10

申请号：US18319630

申请日：2023-05-18

申请人： NOVARTIS AG

发明人： Luigi Franchi , Shomir Ghosh , Gary Glick , Jason Katz , Anthony William Opipari, Jr. , William Roush , Hans Martin Seidel , Dong-Ming Shen , Shankar Venkatraman , David Guenther Winkler

IPC分类号： C07D277/36 , C07C307/06 , C07D215/36 , C07D231/18 , C07D239/26 , C07D263/46 , C07D307/64 , C07D307/79 , C07D317/62 , C07D333/34 , C07D487/04 , C07C335/42 , C07D213/71 , C07D231/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04

CPC分类号： C07D277/36 , C07C307/06 , C07D215/36 , C07D231/18 , C07D239/26 , C07D263/46 , C07D307/64 , C07D307/79 , C07D317/62 , C07D333/34 , C07D487/04 , C07C335/42 , C07D213/71 , C07D231/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04

摘要： In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured:

or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

3.

发明授权
Compounds and compositions for treating conditions associated with NLRP activity 有权

公开(公告)号：US11203579B2

公开(公告)日：2021-12-21

申请号：US16632849

申请日：2018-07-23

申请人： Novartis AG

发明人： Luigi Franchi , Shomir Ghosh , Gary Glick , Jason Katz , Anthony William Opipari, Jr. , William Roush , Hans Martin Seidel , Dong-Ming Shen , Shankar Venkatraman , David Guenther Winkler

IPC分类号： C07D277/36 , C07D307/64 , C07D333/34 , C07C307/06 , C07D215/36 , C07D231/18 , C07D239/26 , C07D263/46 , C07D307/79 , C07D317/62 , C07D487/04 , C07C335/42 , C07D213/71 , C07D231/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04

摘要： In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured. The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging.