公开(公告)号：US20200268749A1

公开(公告)日：2020-08-27

申请号：US16646390

申请日：2018-09-11

Applicant: NOVARTIS AG

Inventor： Vesselina COOKE ,  Michael Scott VISSER ,  Andrew WYLIE ,  Padmaja YERRAMILLI-RAO ,  Xu ZHU

IPC: A61K31/497 ,  A61K45/06 ,  A61K9/00 ,  A61P35/00

Abstract: The present disclosure relates to use of a protein kinase C (PKC) inhibitor in the treatment or prevention of proliferative diseases. The disclosure also relates to corresponding pharmaceutical formulations, uses, methods, combinations, and related disclosure embodiments. The disclosure further relates to use of a pharmaceutical combination comprising a PKC inhibitor and another therapeutic agent, such as an MDM2 inhibitor, in the treatment or prevention of a proliferative disease.

公开(公告)号：US20230174933A1

公开(公告)日：2023-06-08

申请号：US17801665

申请日：2021-02-26

Applicant: Novartis AG

Inventor： Jennifer BROGDON ,  Seth CARBONNEAU ,  Glenn DRANOFF ,  Michael R. Greene ,  Anniesha HACK ,  Marc Horst Peter HILD ,  Olja KODRASI ,  Elizabeth Dorothy PRATICO ,  Andrew PRICE ,  Andrew Marc STEIN ,  Attilio BONDANZA ,  Boris ENGELS ,  Carla Patricia Pinto GUIMARAES ,  Hyungwook LIM ,  Sujata SHARMA ,  Akash SOHONI ,  Louise TREANOR ,  Xu ZHU

IPC: C12N5/0783 ,  A61K35/17 ,  A61P35/00 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725 ,  C07K14/47 ,  C07K14/71 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06 ,  A61P35/02

CPC classification number: C12N5/0636 ,  A61K35/17 ,  A61P35/00 ,  C07K16/2878 ,  C07K14/70517 ,  C07K14/7051 ,  C07K14/70578 ,  C07K14/4702 ,  C07K14/71 ,  A61K38/1774 ,  A61K38/177 ,  A61K38/1709 ,  A61K38/179 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2803 ,  A61P35/02 ,  C07K2319/33 ,  A61K2039/505

Abstract: This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.

公开(公告)号：US20230256017A1

公开(公告)日：2023-08-17

申请号：US17801669

申请日：2021-02-26

Applicant: Jennifer BROGDON ,  Glenn DRANOFF ,  Michael R. GREENE ,  Anniesha HACK ,  Olja KODRASI ,  Elizabeth Dorothy PRATICO ,  Andrew PRICE ,  Andrew Marc STEIN ,  Amy RAYO ,  Jennifer YANG ,  Brian Walter GRANDA ,  Novartis AG

Inventor： Jennifer BROGDON ,  Glenn DRANOFF ,  Michael R. GREENE ,  Anniesha HACK ,  Olja KODRASI ,  Elizabeth Dorothy PRATICO ,  Andrew PRICE ,  Andrew Marc STEIN ,  Amy RAYO ,  Jennifer YANG ,  Brian Walter GRANDA ,  Attilio BONDANZA ,  Boris ENGELS ,  Hyungwook LIM ,  Akash SOHONI ,  Louise TREANOR ,  Xu ZHU ,  Carla GUIMARAES ,  Shyamali JAYASHANKAR ,  Sandeep Tharian KOSHY ,  Regis CEBE ,  Michael BARDROFF ,  Sandra MILLER

IPC: A61K35/17 ,  A61P35/00

CPC classification number: A61K35/17 ,  A61P35/00

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.