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公开(公告)号：US20230256017A1
公开(公告)日：2023-08-17
申请号：US17801669
申请日：2021-02-26
Applicant: Jennifer BROGDON , Glenn DRANOFF , Michael R. GREENE , Anniesha HACK , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Amy RAYO , Jennifer YANG , Brian Walter GRANDA , Novartis AG
Inventor： Jennifer BROGDON , Glenn DRANOFF , Michael R. GREENE , Anniesha HACK , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Amy RAYO , Jennifer YANG , Brian Walter GRANDA , Attilio BONDANZA , Boris ENGELS , Hyungwook LIM , Akash SOHONI , Louise TREANOR , Xu ZHU , Carla GUIMARAES , Shyamali JAYASHANKAR , Sandeep Tharian KOSHY , Regis CEBE , Michael BARDROFF , Sandra MILLER
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US20220153835A1
公开(公告)日：2022-05-19
申请号：US17491420
申请日：2021-09-30
Applicant: NOVARTIS AG , IMMUTEP S.A.S.
Inventor： Glenn DRANOFF , Frederic TRIEBEL , Chrystelle BRIGNONE , Walter A. BLATTLER , Jennifer Marie MATARAZA , Catherine Ann SABATOS-PEYTON , Hwai Wen CHANG , Gerhard Johann FREY
IPC: C07K16/28
Abstract: Combination therapies comprising antibody molecules that specifically bind to LAG-3 are disclosed. The combination therapies can be used to treat, prevent and/or diagnose cancerous or infectious disorders.
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公开(公告)号：US20170368047A1
公开(公告)日：2017-12-28
申请号：US15675987
申请日：2017-08-14
Applicant: Novartis AG , Dana-Farber Cancer Institute, Inc.
Inventor： Leigh ZAWEL , Christopher S. STRAUB , Brant G. FIRESTONE , Glenn DRANOFF , Michael DOUGAN
IPC: A61K31/4439 , A61K31/427 , A61K31/421 , A61K31/506 , A61K39/00 , A61K39/39
Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
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公开(公告)号：US20240417722A1
公开(公告)日：2024-12-19
申请号：US18534209
申请日：2023-12-08
Applicant: NOVARTIS AG , INTELLIA THERAPEUTICS, INC.
Inventor： Ming-Wei CHEN , Melissa DECK , Glenn DRANOFF , Craig Stephen MICKANIN , Reynald LESCARBEAU , Celeste RICHARDSON , Morag STEWART , Yi YANG
IPC: C12N15/113 , A61K9/00 , A61K31/7088 , A61K38/17 , A61K38/46 , A61K39/00 , A61K45/06 , C12N5/0783 , C12N15/09 , C12N15/10
Abstract: The present invention is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20230174933A1
公开(公告)日：2023-06-08
申请号：US17801665
申请日：2021-02-26
Applicant: Novartis AG
Inventor： Jennifer BROGDON , Seth CARBONNEAU , Glenn DRANOFF , Michael R. Greene , Anniesha HACK , Marc Horst Peter HILD , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Attilio BONDANZA , Boris ENGELS , Carla Patricia Pinto GUIMARAES , Hyungwook LIM , Sujata SHARMA , Akash SOHONI , Louise TREANOR , Xu ZHU
IPC: C12N5/0783 , A61K35/17 , A61P35/00 , C07K16/28 , C07K14/705 , C07K14/725 , C07K14/47 , C07K14/71 , A61K38/17 , A61K39/395 , A61K45/06 , A61P35/02
CPC classification number: C12N5/0636 , A61K35/17 , A61P35/00 , C07K16/2878 , C07K14/70517 , C07K14/7051 , C07K14/70578 , C07K14/4702 , C07K14/71 , A61K38/1774 , A61K38/177 , A61K38/1709 , A61K38/179 , A61K39/39558 , A61K45/06 , C07K16/2803 , A61P35/02 , C07K2319/33 , A61K2039/505
Abstract: This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.
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Patent Agency Ranking
公开(公告)号：US20210015860A1
公开(公告)日：2021-01-21
申请号：US16845030
申请日：2020-04-09
Applicant: NOVARTIS AG
Inventor： Jennifer BROGDON , Daniela CIPOLLETTA , Glenn DRANOFF , Deborah A. KNEE , Fei WANG
Abstract: The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.
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公开(公告)号：US20180362975A1
公开(公告)日：2018-12-20
申请号：US15780751
申请日：2016-12-02
Applicant: Novartis AG , Intellia Therapeutics, Inc.
Inventor： Ming-Wei CHEN , Melissa DECK , Glenn DRANOFF , Craig Stephen MACKANIN , Reynald LESCARBEAU , Celeste RICHARDSON , Morag Helen STEWART , Yi YANG
IPC: C12N15/113 , A61K35/17 , A61K38/46 , A61K9/00 , A61K38/17 , A61K45/06 , A61K31/7088
Abstract: The present invention is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20220296581A1
公开(公告)日：2022-09-22
申请号：US17832911
申请日：2022-06-06
Applicant: NOVARTIS AG , DANA-FARBER CANCER INSTITUTE, INC.
Inventor： Leigh ZAWEL , Christopher S. STRAUB , Brant G. FIRESTONE , Glenn DRANOFF , Michael DOUGAN
IPC: A61K31/4439 , A61K31/421 , A61K31/427 , A61K31/506 , A61K39/00 , A61K39/39
Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
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公开(公告)号：US20210123075A1
公开(公告)日：2021-04-29
申请号：US17058381
申请日：2019-06-07
Applicant: NOVARTIS AG , INTELLIA THERAPEUTICS, INC.
Inventor： Ming-Wei CHEN , Glenn DRANOFF
IPC: C12N15/86 , C12N9/22 , C12N15/113
Abstract: The present disclosure is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20200345714A1
公开(公告)日：2020-11-05
申请号：US16926930
申请日：2020-07-13
Applicant: NOVARTIS AG , DANA-FARBER CANCER INSTITUTE, INC.
Inventor： Leigh ZAWEL , Christopher S. STRAUB , Brant G. FIRESTONE , Glenn DRANOFF , Michael DOUGAN
IPC: A61K31/4439 , A61K31/421 , A61K31/427 , A61K31/506 , A61K39/00 , A61K39/39
Abstract: The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
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