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公开(公告)号：US20170152313A1
公开(公告)日：2017-06-01
申请号：US15346026
申请日：2016-11-08
Applicant: NOVARTIS AG
Inventor： Kurt Alex HELDWEIN , Igor SPLAWSKI , Jennifer BROGDON , Joshua GOLDSTEIN , William DOLE , John TRAUGER , Chonghui ZHANG
IPC: C07K16/28 , A61K45/06 , A61K9/00 , A61K39/395
CPC classification number: C07K16/28 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/4726 , C07K16/2851 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
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公开(公告)号：US20230174933A1
公开(公告)日：2023-06-08
申请号：US17801665
申请日：2021-02-26
Applicant: Novartis AG
Inventor： Jennifer BROGDON , Seth CARBONNEAU , Glenn DRANOFF , Michael R. Greene , Anniesha HACK , Marc Horst Peter HILD , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Attilio BONDANZA , Boris ENGELS , Carla Patricia Pinto GUIMARAES , Hyungwook LIM , Sujata SHARMA , Akash SOHONI , Louise TREANOR , Xu ZHU
IPC: C12N5/0783 , A61K35/17 , A61P35/00 , C07K16/28 , C07K14/705 , C07K14/725 , C07K14/47 , C07K14/71 , A61K38/17 , A61K39/395 , A61K45/06 , A61P35/02
CPC classification number: C12N5/0636 , A61K35/17 , A61P35/00 , C07K16/2878 , C07K14/70517 , C07K14/7051 , C07K14/70578 , C07K14/4702 , C07K14/71 , A61K38/1774 , A61K38/177 , A61K38/1709 , A61K38/179 , A61K39/39558 , A61K45/06 , C07K16/2803 , A61P35/02 , C07K2319/33 , A61K2039/505
Abstract: This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.
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公开(公告)号：US20190040128A1
公开(公告)日：2019-02-07
申请号：US15971250
申请日：2018-05-04
Applicant: NOVARTIS AG
Inventor： Kurt Alex HELDWEIN , Igor SPLAWSKI , Jennifer BROGDON , Joshua GOLDSTEIN , William DOLE , John TRAUGER , Chonghui ZHANG
IPC: C07K16/28 , A61P9/08 , A61P9/12 , A61P9/04 , A61K9/00 , A61K39/395 , A61K45/06 , A61P9/10 , A61K39/00 , C07K14/47
Abstract: The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.
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Patent Agency Ranking
公开(公告)号：US20210071182A1
公开(公告)日：2021-03-11
申请号：US16498361
申请日：2018-03-21
Applicant: NOVARTIS AG , INTELLIA THERAPEUTICS, INC.
Inventor： Jennifer BROGDON , Ming-Wei CHEN , Hyungwook LIM , Yi YANG , Morag STEWART , Sarah HESSE
IPC: C12N15/113 , C07K14/705 , A61K35/17 , C12N9/22 , C12N15/86
Abstract: The present disclosure is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20170306037A1
公开(公告)日：2017-10-26
申请号：US15517867
申请日：2015-10-08
Applicant: NOVARTIS AG
Inventor： Jennifer BROGDON , Daniela CIPOLLETTA , Glenn DRANOFF , Deborah A. KNEE , Fei WANG
Abstract: The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.
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公开(公告)号：US20250109401A1
公开(公告)日：2025-04-03
申请号：US18486393
申请日：2023-10-13
Applicant: NOVARTIS AG , INTELLIA THERAPEUTICS, INC.
Inventor： Jennifer BROGDON , Ming-Wei CHEN , Hyungwook LIM , Yi YANG , Morag STEWART , Sarah HESSE
IPC: C12N15/113 , A61K39/00 , C07K14/705 , C12N9/22 , C12N15/86
Abstract: The present disclosure is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20230256017A1
公开(公告)日：2023-08-17
申请号：US17801669
申请日：2021-02-26
Applicant: Jennifer BROGDON , Glenn DRANOFF , Michael R. GREENE , Anniesha HACK , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Amy RAYO , Jennifer YANG , Brian Walter GRANDA , Novartis AG
Inventor： Jennifer BROGDON , Glenn DRANOFF , Michael R. GREENE , Anniesha HACK , Olja KODRASI , Elizabeth Dorothy PRATICO , Andrew PRICE , Andrew Marc STEIN , Amy RAYO , Jennifer YANG , Brian Walter GRANDA , Attilio BONDANZA , Boris ENGELS , Hyungwook LIM , Akash SOHONI , Louise TREANOR , Xu ZHU , Carla GUIMARAES , Shyamali JAYASHANKAR , Sandeep Tharian KOSHY , Regis CEBE , Michael BARDROFF , Sandra MILLER
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US20210015860A1
公开(公告)日：2021-01-21
申请号：US16845030
申请日：2020-04-09
Applicant: NOVARTIS AG
Inventor： Jennifer BROGDON , Daniela CIPOLLETTA , Glenn DRANOFF , Deborah A. KNEE , Fei WANG
Abstract: The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.
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