公开(公告)号：US10760105B2

公开(公告)日：2020-09-01

申请号：US15540916

申请日：2015-12-29

申请人： NOVOGY, INC.

发明人： Arthur J. Shaw, IV ,  Johannes Pieter Van Dijken ,  Annapurna Kamineni ,  Jonathan Friedlander ,  Vasiliki Tsakraklides ,  Maureen Hamilton ,  Elena E. Brevnova

IPC分类号： C12N15/63 ,  C12N15/81 ,  C12P7/64 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88 ,  C12P5/00 ,  C12P7/04 ,  C12N1/20

摘要： Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.

公开(公告)号：US20170096691A1

公开(公告)日：2017-04-06

申请号：US15303330

申请日：2015-04-08

申请人： Novogy, Inc.

发明人： Emily H. Greenhagen ,  Maureen Hamilton ,  William G. LaTouf ,  Andrew L. Consiglio ,  Kyle M. MacEwen ,  Arthur J. Shaw, IV

IPC分类号： C12P13/00 ,  C12N15/81 ,  C12N15/52 ,  C12N9/86 ,  C12N9/80 ,  C12N15/70 ,  C12N9/78

CPC分类号： C12P13/001 ,  C12N9/78 ,  C12N9/80 ,  C12N9/86 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12P7/6463 ,  C12Y305/01054 ,  C12Y305/01084 ,  C12Y305/02015 ,  C12Y305/04 ,  C12Y305/04003 ,  C12Y305/99004

摘要： Disclosed are transformed cells and related nucleotide and protein sequences, and fermentation compositions and methods, all of which are related to providing selective advantage in fermentation. For example, a selective advantage results from transformation of a cell with a nucleic acid that allows a transformed cell to metabolize one or more nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell cannot metabolize, and from fermentation of the transformed cell using one or more feedstocks, such as fractioned grain, which are depleted in or free of conventional nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell can metabolize. Also disclosed are methods for improved oxygen transfer in an aerobic or microaerobic fermentation.