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公开(公告)号：US10260052B2
公开(公告)日：2019-04-16
申请号：US15120952
申请日：2015-02-24
申请人： Novogy, Inc.
摘要： DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for expression in an oleaginous yeast host of polynucleotide sequences encoding DGA1 from Rhodosporidium toruloides, Lipomyces starkeyi, Aurantiochytrium limacinium, Aspergillus terreus, or Claviceps purpurea. Also described herein are engineered recombinant host cells of Yarrowia lipolytica comprising heterologous DGA1 polynucleotides encoding DGA1 proteins, or functionally active portions thereof, having the capability of producing increased lipid production and possessing the characteristic of enhanced glucose consumption efficiency.
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公开(公告)号：US10174296B2
公开(公告)日：2019-01-08
申请号：US14914817
申请日：2014-08-27
申请人： Novogy, Inc.
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical phosphorus or sulfur sources. Fermentation methods using the genetically engineered organisms are also described. The fermentation methods are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
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公开(公告)号：US20160115492A1
公开(公告)日：2016-04-28
申请号：US14759878
申请日：2014-01-06
申请人： NOVOGY, INC.
发明人： Colin R. South , Arthur J. Shaw, IV
CPC分类号： C12N15/815 , C12N1/20 , C12N9/14 , C12N9/88 , C12N15/70 , C12N15/81 , C12P3/00 , C12Y308/01 , C12Y402/01069
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
摘要翻译： 公开了具有代谢非典型氮源的能力的基因工程生物，如酵母和细菌，如三聚氰胺和氨腈。 还描述了使用遗传工程生物的发酵方法。 本发明的方法是用于各种化合物（包括商品，精细化学品和药物）的工业生物生产的可靠工艺。
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公开(公告)号：US10457963B2
公开(公告)日：2019-10-29
申请号：US15710734
申请日：2017-09-20
申请人： Novogy, Inc.
摘要： Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
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公开(公告)号：US09765348B2
公开(公告)日：2017-09-19
申请号：US14759878
申请日：2014-01-06
申请人： Novogy, Inc.
发明人： Colin R. South , Arthur J. Shaw, IV
CPC分类号： C12N15/815 , C12N1/20 , C12N9/14 , C12N9/88 , C12N15/70 , C12N15/81 , C12P3/00 , C12Y308/01 , C12Y402/01069
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
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公开(公告)号：US10760105B2
公开(公告)日：2020-09-01
申请号：US15540916
申请日：2015-12-29
申请人： NOVOGY, INC.
发明人： Arthur J. Shaw, IV , Johannes Pieter Van Dijken , Annapurna Kamineni , Jonathan Friedlander , Vasiliki Tsakraklides , Maureen Hamilton , Elena E. Brevnova
IPC分类号： C12N15/63 , C12N15/81 , C12P7/64 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12P5/00 , C12P7/04 , C12N1/20
摘要： Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.
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公开(公告)号：US10724041B2
公开(公告)日：2020-07-28
申请号：US15313187
申请日：2015-05-29
申请人： Novogy, Inc.
IPC分类号： C12N15/81 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/20 , C12N15/52 , C12P7/64 , C07K14/39 , C12N9/16
摘要： Disclosed are nucleotide sequences and corresponding amino acid sequences of Arxula adeninivorans genes that can be utilized to manipulate the lipid content and/or composition of a cell. Methods and compositions for utilizing this information are disclosed to increase the lipid content or modify the lipid composition of a cell by either increasing or decreasing the activity of certain genetic targets.
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公开(公告)号：US20170096691A1
公开(公告)日：2017-04-06
申请号：US15303330
申请日：2015-04-08
申请人： Novogy, Inc.
发明人： Emily H. Greenhagen , Maureen Hamilton , William G. LaTouf , Andrew L. Consiglio , Kyle M. MacEwen , Arthur J. Shaw, IV
CPC分类号： C12P13/001 , C12N9/78 , C12N9/80 , C12N9/86 , C12N15/52 , C12N15/70 , C12N15/81 , C12P7/6463 , C12Y305/01054 , C12Y305/01084 , C12Y305/02015 , C12Y305/04 , C12Y305/04003 , C12Y305/99004
摘要： Disclosed are transformed cells and related nucleotide and protein sequences, and fermentation compositions and methods, all of which are related to providing selective advantage in fermentation. For example, a selective advantage results from transformation of a cell with a nucleic acid that allows a transformed cell to metabolize one or more nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell cannot metabolize, and from fermentation of the transformed cell using one or more feedstocks, such as fractioned grain, which are depleted in or free of conventional nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell can metabolize. Also disclosed are methods for improved oxygen transfer in an aerobic or microaerobic fermentation.
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公开(公告)号：US20190316098A1
公开(公告)日：2019-10-17
申请号：US16288544
申请日：2019-02-28
申请人： NOVOGY, INC.
摘要： DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for expression in an oleaginous yeast host of polynucleotide sequences encoding DGA1 from Rhodosporidium toruloides, Lipomyces starkeyi, Aurantiochytrium limacinum, Aspergillus terreus, or Claviceps purpurea. Also described herein are engineered recombinant host cells of Yarrowia lipolytica comprising heterologous DGA1 polynucleotides encoding DGA1 proteins, or functionally active portions thereof, having the capability of producing increased lipid production and possessing the characteristic of enhanced glucose consumption efficiency.
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公开(公告)号：US20180105848A1
公开(公告)日：2018-04-19
申请号：US15710734
申请日：2017-09-20
申请人： Novogy, Inc.
CPC分类号： C12P7/6409 , A23D9/02 , C11B1/10 , C11C3/00 , C12N9/001 , C12N9/1007 , C12Q1/686
摘要： Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
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