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    Methods for producing polypeptides in protease-deficient mutants of Trichoderma
    4.
    发明授权
    Methods for producing polypeptides in protease-deficient mutants of Trichoderma 有权

    公开(公告)号：US11427847B2

    公开(公告)日：2022-08-30

    申请号：US17163033

    申请日：2021-01-29

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12N15/80 ,  C12P21/02 ,  C12N15/04 ,  C12N9/58

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

    Methods for producing polypeptides in protease-deficient mutants of trichoderma
    5.
    发明授权
    Methods for producing polypeptides in protease-deficient mutants of trichoderma 有权

    公开(公告)号：US11078508B2

    公开(公告)日：2021-08-03

    申请号：US16211632

    申请日：2018-12-06

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12P21/02 ,  C12N9/58 ,  C12N15/80 ,  C12N15/04

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

    Methods for Producing Polypeptides in Protease-Deficient Mutants of Trichoderma
    7.
    发明申请
    Methods for Producing Polypeptides in Protease-Deficient Mutants of Trichoderma 有权

    公开(公告)号：US20210155967A1

    公开(公告)日：2021-05-27

    申请号：US17163033

    申请日：2021-01-29

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12N15/80 ,  C12P21/02 ,  C12N9/58

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

    Methods for producing polypeptides in protease-deficient mutants of Trichoderma
    10.
    发明授权
    Methods for producing polypeptides in protease-deficient mutants of Trichoderma 有权

    公开(公告)号：US11078510B2

    公开(公告)日：2021-08-03

    申请号：US16996168

    申请日：2020-08-18

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12N15/80 ,  C12P21/02 ,  C12N15/04 ,  C12N9/58

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

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