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    SPORE-BASED PROBIOTIC COMPOSITION FOR REDUCTION OF DIETARY ENDOTOXEMIA AND RELATED METHODS
    2.
    发明申请
    SPORE-BASED PROBIOTIC COMPOSITION FOR REDUCTION OF DIETARY ENDOTOXEMIA AND RELATED METHODS 有权

    公开(公告)号：US20230049876A1

    公开(公告)日：2023-02-16

    申请号：US17968161

    申请日：2022-10-18

    申请人： Novozymes A/S

    发明人： Kiran Krishnan ,  Dale Kriz ,  Thomas Bayne

    IPC分类号： A61K35/742 ,  A61K35/744 ,  A61P31/04 ,  A61K35/747 ,  A23L31/10 ,  A23L33/135 ,  A61K35/745 ,  A23L33/14

    摘要： A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, and Bacillus clausii. One or more of a level of blood endotoxin, triglyceride, post-prandial insulin, post-prandial ghrelin level, MCP-1, GM-CSF, IL-12p70, IL-13, IL-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, and TNF-α is observed as being lower after spore-based probiotic supplementation when compared to placebo. At least one of post-prandial leptin and IL-10 is observed as being higher after spore-based probiotic supplementation when compared to placebo.