公开(公告)号：US20220213449A1

公开(公告)日：2022-07-07

申请号：US17646212

申请日：2021-12-28

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Dan Jun LI ,  Dexue SUN ,  Byron DELABARRE ,  Vijaya BALAKRISHNAN ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Grace Y. OLINGER

IPC分类号： C12N9/06 ,  C07K14/54 ,  C07K14/715 ,  C12N15/85 ,  A61K35/17 ,  C07K14/705

摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20200172879A1

公开(公告)日：2020-06-04

申请号：US16558224

申请日：2019-09-02

申请人： OBSIDIAN THERAPEUTICS, INC.

发明人： Vipin SURI ,  Dan Jun LI ,  Dexue SUN ,  Byron DELABARRE ,  Vijaya BALAKRISHNAN ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Grace Y. OLINGER

IPC分类号： C12N9/06 ,  C07K14/54 ,  C07K14/715 ,  C07K14/705 ,  C12N15/85 ,  A61K35/17

摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20220403001A1

公开(公告)日：2022-12-22

申请号：US17251635

申请日：2019-06-12

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Celeste RICHARDSON ,  Brian DOLINSKI ,  Abhishek KULKARNI ,  Mara Christine INNISS ,  Dexue SUN ,  Dan Jun LI ,  Grace Y. OLINGER ,  Scott Francis HELLER ,  Jennifer Leah GORI ,  Byron DELABARRE

IPC分类号： C07K14/705 ,  C12N9/16 ,  A61K31/53 ,  A61K31/519 ,  A61K31/4985

摘要： The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3′,5′-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.

公开(公告)号：US20220170011A1

公开(公告)日：2022-06-02

申请号：US17548076

申请日：2021-12-10

申请人： OBSIDIAN THERAPEUTICS, INC.

发明人： Mara Christine INNISS ,  Grace Y. OLINGER ,  Samantha FLEURY ,  Jennifer Leah GORI

IPC分类号： C12N15/11 ,  C12N9/22 ,  C12N15/90 ,  C12N15/86 ,  A61K35/22 ,  A61K31/7105

摘要： The present disclosure provides compositions and methods related to regulatable Cas systems. Such systems provide for ligand-dependent, modular and tunable Cas protein expression and activity.