公开(公告)号：US20220213449A1

公开(公告)日：2022-07-07

申请号：US17646212

申请日：2021-12-28

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Dan Jun LI ,  Dexue SUN ,  Byron DELABARRE ,  Vijaya BALAKRISHNAN ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Grace Y. OLINGER

IPC分类号： C12N9/06 ,  C07K14/54 ,  C07K14/715 ,  C12N15/85 ,  A61K35/17 ,  C07K14/705

摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20210386788A1

公开(公告)日：2021-12-16

申请号：US17288373

申请日：2019-10-23

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Dexue SUN ,  Michelle Lynn OLS ,  Scott Francis HELLER ,  Dan Jun LI ,  Celeste RICHARDSON ,  Mara Christine INNISS ,  Jennifer Leah GORI ,  Benjamin J. PRIMACK ,  Abhishek KULKARNI ,  Brian DOLINSKI ,  Tucker Read EZELL ,  Michael SCHEBESTA ,  James A. STORER ,  Kutlu Goksu ELPEK

IPC分类号： A61K35/28 ,  A61K31/4535 ,  A61K31/55 ,  C07K14/705 ,  C07K16/28 ,  C07K14/725 ,  C07K14/54 ,  C07K14/715 ,  A61P35/00

摘要： The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20220056092A1

公开(公告)日：2022-02-24

申请号：US17413512

申请日：2019-12-11

申请人： Obsidian Therapeutics, Inc.

发明人： Michelle Lynn OLS ,  Vipin SURI ,  Dexue SUN ,  Dan Jun LI ,  Dhruv Kam SETHI ,  Abhishek KULKARNI ,  Benjamin J. PRIMACK ,  James STORER

IPC分类号： C07K14/54 ,  C07K14/725 ,  C07K16/28 ,  A61K35/17 ,  A61P35/00

摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

公开(公告)号：US20200172879A1

公开(公告)日：2020-06-04

申请号：US16558224

申请日：2019-09-02

申请人： OBSIDIAN THERAPEUTICS, INC.

发明人： Vipin SURI ,  Dan Jun LI ,  Dexue SUN ,  Byron DELABARRE ,  Vijaya BALAKRISHNAN ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Grace Y. OLINGER

IPC分类号： C12N9/06 ,  C07K14/54 ,  C07K14/715 ,  C07K14/705 ,  C12N15/85 ,  A61K35/17

摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20220403001A1

公开(公告)日：2022-12-22

申请号：US17251635

申请日：2019-06-12

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Celeste RICHARDSON ,  Brian DOLINSKI ,  Abhishek KULKARNI ,  Mara Christine INNISS ,  Dexue SUN ,  Dan Jun LI ,  Grace Y. OLINGER ,  Scott Francis HELLER ,  Jennifer Leah GORI ,  Byron DELABARRE

IPC分类号： C07K14/705 ,  C12N9/16 ,  A61K31/53 ,  A61K31/519 ,  A61K31/4985

摘要： The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3′,5′-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.

公开(公告)号：US20220175781A1

公开(公告)日：2022-06-09

申请号：US17436997

申请日：2020-03-06

申请人： Obsidian Therapeutics, Inc.

发明人： Michael SCHEBESTA ,  Michelle Lois FLEURY ,  Kutlu Goksu ELPEK ,  Elizabeth Jane WEISMAN ,  Vipin SURI ,  Dexue SUN ,  Dan Jun LI ,  Steven Mark SHAMAH ,  Michael Joseph BRISKIN ,  Celeste RICHARDSON ,  Tariq A. KASSUM ,  Michelle Lynn OLS ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Emily BRIDEAU ,  Jennifer Leah GORI ,  Dhruv Kam SETHI

IPC分类号： A61K31/519 ,  C12N9/06 ,  A61K31/55

摘要： The present disclosure provides regulatable biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.