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公开(公告)号：US20200172879A1
公开(公告)日：2020-06-04
申请号：US16558224
申请日：2019-09-02
发明人： Vipin SURI , Dan Jun LI , Dexue SUN , Byron DELABARRE , Vijaya BALAKRISHNAN , Brian DOLINSKI , Mara Christine INNISS , Grace Y. OLINGER
IPC分类号： C12N9/06 , C07K14/54 , C07K14/715 , C07K14/705 , C12N15/85 , A61K35/17
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20230026259A1
公开(公告)日：2023-01-26
申请号：US17436892
申请日：2020-03-06
发明人： Vipin SURI , Celeste RICHARDSON , Brian DOLINSKI , Abhishek KULKARNI , Mara Christine Inniss , Dexue SUN , Elizabeth Jane WEISMAN , Grace Y. Olinger , Scott Francis HELLER , Jennifer Leah GORI , Michelle Lynn OLS , Kutlu Goksu ELPEK , Tucker Read EZELL , Michael SCHEBESTA , Michelle Lois FLEURY , Dhruv Kam SETHI
IPC分类号： C12N9/88 , A61K39/00 , C07K14/705
摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.
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公开(公告)号：US20220213449A1
公开(公告)日：2022-07-07
申请号：US17646212
申请日：2021-12-28
发明人： Vipin SURI , Dan Jun LI , Dexue SUN , Byron DELABARRE , Vijaya BALAKRISHNAN , Brian DOLINSKI , Mara Christine INNISS , Grace Y. OLINGER
IPC分类号： C12N9/06 , C07K14/54 , C07K14/715 , C12N15/85 , A61K35/17 , C07K14/705
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20210386788A1
公开(公告)日：2021-12-16
申请号：US17288373
申请日：2019-10-23
发明人： Vipin SURI , Dexue SUN , Michelle Lynn OLS , Scott Francis HELLER , Dan Jun LI , Celeste RICHARDSON , Mara Christine INNISS , Jennifer Leah GORI , Benjamin J. PRIMACK , Abhishek KULKARNI , Brian DOLINSKI , Tucker Read EZELL , Michael SCHEBESTA , James A. STORER , Kutlu Goksu ELPEK
IPC分类号： A61K35/28 , A61K31/4535 , A61K31/55 , C07K14/705 , C07K16/28 , C07K14/725 , C07K14/54 , C07K14/715 , A61P35/00
摘要： The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20220403001A1
公开(公告)日：2022-12-22
申请号：US17251635
申请日：2019-06-12
发明人： Vipin SURI , Celeste RICHARDSON , Brian DOLINSKI , Abhishek KULKARNI , Mara Christine INNISS , Dexue SUN , Dan Jun LI , Grace Y. OLINGER , Scott Francis HELLER , Jennifer Leah GORI , Byron DELABARRE
IPC分类号： C07K14/705 , C12N9/16 , A61K31/53 , A61K31/519 , A61K31/4985
摘要： The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3′,5′-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.
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公开(公告)号：US20220175781A1
公开(公告)日：2022-06-09
申请号：US17436997
申请日：2020-03-06
发明人： Michael SCHEBESTA , Michelle Lois FLEURY , Kutlu Goksu ELPEK , Elizabeth Jane WEISMAN , Vipin SURI , Dexue SUN , Dan Jun LI , Steven Mark SHAMAH , Michael Joseph BRISKIN , Celeste RICHARDSON , Tariq A. KASSUM , Michelle Lynn OLS , Brian DOLINSKI , Mara Christine INNISS , Emily BRIDEAU , Jennifer Leah GORI , Dhruv Kam SETHI
IPC分类号： A61K31/519 , C12N9/06 , A61K31/55
摘要： The present disclosure provides regulatable biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
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